Produits biochimiques et réactifs

<p>The cyclic pentapeptide cyclo(-Arg-Gly-Asp-d-Phe-Lys-) is a highly potent and selective inhibitor for the alphavβ3 integrin receptor. A related compound, cyclo(-Arg-Gly-Asp-d-Phe-Val), is a promising anti-cancer drug candidate- it inhibits angiogenesis and induces apoptosis in vascular cells.Cyclic RGD-containing peptides are selective antagonists of integrins, proteins that play important roles in cell-cell and cell-matrix interactions. In a suitably labelled form, these peptides may serve as useful tools for diagnostic imaging and peptide targeted therapy of some types of cancer.</p>

<p>Peptide H-TNYLTHR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Angiotensin I-converting enzyme (ACE) plays a critical role in blood pressure regulation. There is a rise in conditions linked to hypertension such as heart attacks, strokes, and dementia. This has led to search for novel inhibitors of ACE to regulate blood pressure. Food-derived bioactive peptides have been identified and utilised for their health-promoting abilities. The tripeptide FSY (Phe-Ser-Tyr) was identified from shrimp (Pandalus borealis) protein hydrolysate as a highly potent inhibitor of ACE activity. FSY is capable of being absorbed in the digestive tract to be transported in the blood to the receptors which is a useful feature for clinical application. Further study can provide deeper understanding of FSY potency on ACE function and may lead to drug development.</p>

<p>Metapneumovirus antibody was raised in mouse using matrix protein of human metapneumovirus as the immunogen.</p>

<p>(Arg)9 is a cationic cell-penetrating peptide (CPP)consisting of 9 arginines. Arginine rich CPPs enter cells in a passive manner through membrane multilamellarity and fusion. Evidently as a CPP, (Arg)9 can function to deliver specific molecules to target cells and can be used for drug delivery purposes.</p>

<p>Peptide Ac-PGLPLSLQNG-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Ac-ELESPPPPYSRYPMD-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Fz7-21 is a potent and selective peptide antagonist of Frizzled 7 (FZD 7) receptor which selectively binds to FZD7 cysteine rich domain (CRD) subclass at the cysteine rich region proximal to the lipid-binding groove. Binding alters the conformation of the CRD and the architecture of its lipid-binding groove and impairs Wnt/β-catenin signalling. Peptide Fz7-21 also shows cross-species binding to both the human and mouse FZD7 CRD.The FZD7 receptor is enriched in intestinal stem cells which express the LGR5 receptor and plays a critical role in the cells self-renewal. FZD7 is essential for maintaining human embryonic stem cells in their undifferentiated state and is therefore an attractive pharmacological target for diseases associated with stem cell dysfunction and cancer biology.FZD7 is also upregulated in subsets of colon, pancreatic and gastric tumours, therefore Fz7-21 serves as a pharmacological probe to explore further the function of FZD7 in stem cell and cancer biology.Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>Ovalbumin (OVA) is the primary protein in egg-white, and is involved in initiating food allergies and asthma. It is a highly immunogenic protein and can be used for peptide conjugation in the development of antibodies.Biotin-OVA (323-339) is a biotin labelled class I (Kb)-restricted peptide epitope of OVA. The ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.</p>

<p>SARS-inhibitor 4</p>

<p>Amino acids 45-73, derived from the exon 2/insert 1 domain, of tubulin-associated unit (tau). Tau is a phosphoprotein protein involved in microtubule (MT) assembly and stability as well as brain development. Tau is phosphorylated at multiple sites by several protein kinases, including cyclic-AMP-dependent protein kinases and casein kinase type-1. Tau phosphorylation causes tau to change shape negatively regulating its ability to stimulate MT assembly. Tau is also glycosylated, and O-glycosylation may have a role in its subcellular localisation and degradation.Malfunctioning tau protein contributes to the structural core of the paired helical filaments (PHFs), which make up neurofibrillary tangles (NFTs). NFTs are often observed in neurodegenerative disorders, such as Alzheimer disease and other tauopathies. Tau is expressed from a single gene and is alternatively spliced to yield six different isoforms in the adult central nervous system (CNS).</p>

<p>M13 phage antibody (biotin) was raised in mouse using fd phages from E. coli F+ strain as the immunogen.</p>

<p>Fibrinogen antibody was raised in mouse using fibrin degradation products as the immunogen.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Derived from the haptoglobin protein which binds to and reduces the toxic effects of free haemoglobin, produced during red cell lysis. Decreasing levels of haptoglobin can be used as a marker of haemolysis. The leucine residue at position 11 is isotopically labelled with carbon-13 (6) and nitrogen-15 (1).</p>

<p>VP4 is a viral coat protein of Nora virus encoded for by ORF4. The product of this gene is likely cleaved into three capsid proteins, VP4A, B and C. VP4 is also the most conserved gene from Nora virus and related viruses. Nora virus is a non-pathogenic virus found in gut of Drosophila melanogaster. It causes persistent, non-pathological infection, it replicates in the fly gut and is transmitted via the faecal-oral route. Nora virus has a 12333 nucleotides long single-stranded RNA genome of positive polarity.</p>

<p>hCG beta antibody was raised in mouse using hCG beta as the immunogen.</p>

<p>MIF antibody was raised in Rabbit using Human MIF as the immunogen</p>

<p>Candida albicans antibody (HRP) was raised in rabbit using Candida albicans, type A as the immunogen.</p>

<p>TP10 is an amphipathic cell-penetrating peptide (CPP) also known as transportan 10. Its formation involves the use of a lysine residue to form a chimeric linkage between a mastoparan 21-residue peptide, a wasp venon 14-residue peptide and 6-residues derived from the neuropeptide galanin. Structurally TP10 contains only positively charged amino acids along with 4 lysines and an N-terminus. Therefore, it will produce a +5 charge under conditions of a neutral pH. It has been found that TP10 may aid molecules in penetrating through the cell membrane barrier through directly interacting with the lipid bilayer. During these interactions with the membrane TP10 will form an amphipathic α-helix. TP10 can be used in transduction methods.TP10 is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-TP10 allows a wide variety of applications particularly for conjugation, modification, and peptide design. Fluorescent labelling of TP10 for drug delivery has been used in vivo.</p>

<p>Alyerserin-1c is a C-terminally α-amidated 23 residue Cationic antimicrobial peptide (AMP) with a net charge of +2. Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-1 peptides have limited structural similarity to the ascaphins from the skins of frogs of the Leiopelmatidae family. Alyteserin-1 peptides are selective at inhibiting growth activity of Gram-negative bacteria-such as Escherichia coli and show weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is less likely for resistance to develop towards such peptides compared to conventional antibiotics.</p>

<p>Tryptic peptide fragment from β-Amyloid A4 protein from star-nosed mole. Contains an N-terminal capped cysteine residue. The Leucine residue at position 12 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.</p>

<p>Peptide LCBiot-EPRPEPRPDPRPGPELPLP-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-ENAGEDPGLAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Cilengitide is a cyclic arginine-glycine-aspartic acid (RGD) motif containing peptide that selectively inhibits the integrin alphav subunit. Integrins are cell adhesion molecules which mediate cell-cell and cell-matrix interactions and creating a scaffold for tissue organisation. Integrins also act to regulate cell attachment, proliferation, differentiation, apoptosis and motility.Integrin alphav can form heterodimers with integrin subunits β1, β3, β5, β6, or β8. Cilengitide is a highly selective antagonist of alphavβ3 and alphavβ5 integrins. It also and shows anti-angiogenic effects and inhibits growth and promotes apoptosis of tumour cells that express integrins, such as glioblastoma.Cilengitide has gone on to phase II trials for cancers such as glioblastoma, melanoma, prostate, breast, lung and head and neck cancers.</p>

<p>The Bak BH3 peptide is derived from the pro-apoptotic proteins BAK and BH3, which are both members of the BCL-2 family proteins. It can bind to Bcl-xL, antagonize its anti-apoptotic function, and rapidly induce apoptosis.The process of apoptosis can be activated by the intrinsic or extrinsic pathways, the former is activated by stress stimuli such as DNA damage and nutrient deficiency, while the latter is induced through activation of the death receptors FAS and TRAIL.The BCL-2 family's transmembrane anchor at the C-terminus allows them to locate at the mitochondrial outer membrane and play a vital role in apoptosis.Within the mitochondria BH3 molecules, containing the members BID, BIM, PUMA and NOXA, can be activated by the intrinsic pathway. These in turn can initiate the homo-oligomerisation of BAX and BAK which induce mitochondrial outer membrane permeabilisation (MOMP) and the release of cytochrome c into the cytosol. Here cytochrome c associates with APAF-1 and dATP, ultimately activating effector caspase3/7 and apoptosis.</p>

<p>Collagens are the most abundant family of extra cellular matrix (ECM) proteins, accounting for two-thirds of the dry mass of adult articular cartilage. Several subtypes have been identified including type II, IX, X, XI, VI, XII, and XIV collagen, however 90% of the collagen in the body consists of types I, II, and III. Type I collagen is a long thin protein which consists of three coiled subunits: two alpha 1 (I) (α1(I)) chains and one α2(I). Type I collagen forms part of the major structure of the bone, and mutations in the α1(I) or α2(I) genes lead to-osteogenesis imperfecta,-or brittle-bone disease.The proline residue at position 5 of this peptide is isotopically labelled with carbon-13 (5) and nitrogen-15 (1), giving this peptide a mass increase of 6 compared to the unlabelled peptide.</p>

<p>Peptide H-QGVDDAFYTLVR^^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Presenilin 1 antibody was raised in goat using a synthetic peptide corresponding to amino acid residues 14-33 of the N-terminus of the alzheimer's disease presenilin-1 as the immunogen.</p>

<p>H-DMVLWKDVFRKNNQL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-DMVLWKDVFRKNNQL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-DMVLWKDVFRKNNQL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-DMVLWKDVFRKNNQL-OH at the technical inquiry form on this page</p>

<p>H-AVIFM-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AVIFM-OH is provided at greater that Crude (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AVIFM-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AVIFM-OH at the technical inquiry form on this page</p>

<p>The Influenza A antibody is a powerful tool in the field of Life Sciences. It specifically targets the influenza hemagglutinin, which is a protein found on the surface of the influenza virus. This monoclonal antibody has been extensively studied and characterized using advanced techniques such as FTIR spectroscopy.</p>

<p>The GDNF antibody is a monoclonal antibody that targets the glial cell-derived neurotrophic factor (GDNF). This antibody has been extensively studied for its role in promoting the growth and survival of neurons. It has also been shown to have neutralizing effects on tumor necrosis factor-alpha (TNF-α) and endothelial growth factors. The GDNF antibody is commonly used in immunoassays and research studies in the field of Life Sciences. Its high specificity and affinity make it a valuable tool for studying various growth factors and their functions. Whether you are conducting multidrug experiments or investigating the viscosity of different samples, the GDNF antibody can provide reliable results. Choose this high-quality monoclonal antibody to enhance your research in the field of growth factor biology.</p>

<p>The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. The nucleoprotein has a critical role in virus assembly and RNA transcription. The nucleoprotein is essential in the formation of helical ribonucleoproteins and in regulating viral RNA synthesis. The nucleoprotein can also regulate infected host cellular mechanisms. It is highly expressed during infection and may induce protective immune responses against SARS-CoV and SARS-CoV-2.The nucleoprotein residues FKDQVILLNKHIDAY (346-360) from SARS-CoV-2 have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.</p>

<p>Insulin is a polypeptide composed of two peptide chains referred to as the alpha chain and β chain. These chains are linked by two disulphide bonds, and an additional disulphide is formed within the alpha chain. In most species, the alpha chain consists of 21 amino acids and the β chain of 30 amino acids. Insulin is normally secreted rapidly from the β-cells of the pancreatic islets in response to nutrients absorbed after a meal. In type 1 diabetes mellitus, there may be an absolute insulin deficiency as a consequence of autoimmune destruction of the β-cells. On the other hand, in type 2 diabetes mellitus, insulin secretion is impaired and is inadequate to overcome peripheral insulin resistance.</p>

<p>Vasoactive intestinal peptide (VIP) is a neuropeptide found throughout the body and the central nervous system (CNS). VIP is located within cell bodies and nerve endings of the enteric nervous system, brain and pancreas. VIP neurons in the peripheral system fire to regulate blood vessels, and the  CNS innervate cerebral vasculature. VIP  binds to G protein-coupled receptors VPAC1 and VPAC2. VIP and VPAC2 are detected in circular smooth muscle cells of cerebral arterioles. VIP and VPAC1 are also found in lymphatic tissue. VIP can block inflammation, modify the Th response favouring Th2 and induce regulatory T cells. Overexpression of each receptor has been linked to various cancers.VIP administration leads to pancreatic bicarbonate-rich fluid secretion but not to the same degree stimulated by secretin. VIP stimulates insulin secretion in a glucose-dependent manner and also stimulates glucagon secretion. Studies have found that in morbidly obese patients, VIP levels are lowered and work to slow gastric and duodenal motility but increase gastric emptying. Therefore, decreasing VIP levels in obese patients may increase weight gain by accelerating gastric emptying.VIP has been well studied in pancreatic acini. VIP is a full agonist of amylase secretion and increases cyclic AMP synchronised with an increase in intracellular Ca2+ triggered by stimuli that act through cholecystokinin (CCK) or cholinergic agonists. Most cAMP increases, and amylase secretion appear to be mediated via VPAC1.The discovery of VPAC antagonists can help to understand VIPs roles and may also provide new therapies in VIP dysregulated systems such as cancers. VIP (6-28) is a specific competitive inhibitor of the VIP receptor derived from VIP. VIP-induced vasodilatation was blocked by co-administration of the VIP receptor antagonist VIP (6-28). Using a VIP receptor antagonist has made VIP function easier to study during neuronal injury, inflammation, and heart innervation. The VIP receptor antagonist is being considered for osteoarthritis treatment, an area with no current treatments other than analgesics.</p>

<p>Anti-PYY antibody</p>

<p>GDAP1 antibody was raised in Rabbit using Human GDAP1 as the immunogen</p>

<p>Dipeptide consisting of one serine and one glycine residue with diverse uses.Primary metabolite, inhibitor, bronsted base, forms a complex with Cu(II) acting as a tridentate ligand.Primary metabolites are metabolically or physiologically essential and are directly involved in an organism development, growth, or reproduction. Serylglycine has been detected in foods including spelts (Triticum spelta), and cumins (Cuminum cyminum) and could be a biomarker for the consumption of these foods.</p>

<p>This C-terminal Sortagging peptide acts as a (oligo)glycine nucleophile in the final steps of a sortagging protein labelling reaction. This reaction results in the fluorescent moiety being attached to the C-terminus of the target protein or peptide.A substrate peptide containing the LPXTG motif is recognised and cleaved by the enzyme Sortase A (SrtA) from Staphylococcus aureus. The catalytic cysteine residue in the active site of SrtA, serves as a nucleophile to cleave the peptide bond between threonine and glycine of the substrate peptide. Cleavage results in the formation of a thioacyl intermediate between the substrate peptide and SrtA. This intermediate is then resolved by the N-terminus of this (oligo)glycine nucleophile peptide, resulting in the creation of a new peptide bond that links the substrate peptide to this peptide and its fluorescent dye.  This method of protein labelling is known as sortagging.This peptide contains Sulfocyanine3, which is a fluorescent yellow dye.</p>

<p>CD44 antibody was raised in mouse using T-cell blasts as the immunogen.</p>

<p>This sequence corresponds to the peptide bond between mammalian Lys27- (K27) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.K27-linked chains are less well characterised than other Ub chains, however they have been suggested as a marker of mitochondrial damage and have also been implicated in regulation of innate immunity and DNA repair.The C-terminal lysine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.</p>

<p>Myelin protein zero (MPZ- also termed P0), together with myelin basic protein (MBP- previously termed P1), mediates adhesion between adjacent extracellular membrane surfaces in order to compact the myelin membranes. Myelin protein zero (P0) is the most abundant myelin protein in the peripheral nervous system (PNS), where it is believed to be adhesive on both sides of the membrane through its extracellular and intracellular domains. The extracellular domain of P0 comprises a single Ig domain, whereas the cytoplasmic end is highly positively charged and not predicted to fold into a globular domain.</p>

<p>Axltide-is a substrate peptide for use in kinase assays and is based on the mouse insulin receptor substrate 1 (IRS1) (amino acid 979-989).IRS1 is a membrane-proximal adaptor protein, which binds to, and is phosphorylated by, the insulin receptor (IR) at its tyrosine residue. IRS1 transmits the extracellular signal for insulin to serine/threonine kinases, such as Akt which then deliver the signal into the cell to mediate the various actions of insulin.</p>

<p>Ubiquitin antibody was raised in rabbit using human ubiquitin as the immunogen.</p>

<p>SARS-CoV-2 is an enveloped single-stranded, positive-sense RNA virus. The SARS-CoV-2 nucleocapsid (N) protein is essential for viral RNA replication and new virion assembly. The N protein assembles the positive strand viral genome RNA forming a helical ribonucleocapsid (RNP) during the packaging of the RNA genome. The N protein is also involved in regulating viral RNA synthesis during replication and RNA transcription and modulating metabolism in infected subjects. The arginine residue at position 10 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 10 compared to the unlabelled peptide.</p>

<p>Pantinin-2, like other pantinin peptides, has high activity against Gram-positive bacteria yet weak activity against Gram-negative bacteria. Pantinin-2 also displays activity against Candida tropicalis and has relatively mild haemolytic activity against human red blood cells.</p>

<p>Actin is a highly conserved key cytoskeletal protein involved in numerous structural and functional roles.Actin exists as soluble monomers (G-actin) as well as actin filaments (F-actin). G-actin monomers polymerise to form filaments that organise into dynamic networks with crucial roles in multiple and diverse cellular processes. Actin organisation varies greatly across cell types, and the ordered assembly and turnover of actin networks drive multiple cellular processes, including cell movement, cell adhesion, changes in cell morphology, vesicle trafficking, and cytokinesis. The clinical significance of actin is seen in congenital myopathies, which are characterised by muscle weakness. Mutations in smooth-muscle associated alpha-actin (ACTA2) have been seen to cause coronary heart disease, stroke and thoracic aortic disease. The vascular smooth muscle cell (SMC)-specific isoform of alpha-actin (ACTA2) is a major component of the contractile apparatus in SMCs located throughout the arterial system. By studying and manipulating the actin cytoskeleton, the underlying cause of these myopathies can be understood.</p>

<p>Purified recombinant Transglutaminase 3 (TG3) protein (His tag)</p>

<p>TAT (48-60) amide is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). The 48-60 region of the TAT peptide is an arginine-rich bascic domain which as a whole has three domains that function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively.This peptide has an uncharged C-terminal amide.</p>