Produits biochimiques et réactifs

<p>Chlamydia pneumoniae OMP recombinant protein</p>

<p>IL6 antibody was raised in rabbit using highly pure recombinant hIL-6 as the immunogen.</p>

<p>Pepstatin A is a natural product that inhibits the activity of proteases, particularly chymotrypsin and trypsin. It binds to the active site of these enzymes, blocking access to their substrate. Pepstatin A has been shown to have synergistic effects with other drugs in vitro, such as dapsone and clindamycin. Pepstatin A has inhibitory properties against infectious diseases, including HIV-1 and HIV-2, influenza virus type A (H1N1), herpes simplex virus type 1 (HSV-1), human papilloma virus type 18 (HPV-18), hepatitis C virus (HCV) types 1a and 1b, as well as dengue fever virus. Pepstatin A is also effective in inhibiting polymerase chain reaction amplification of mitochondrial DNA from patients with mitochondrial disorders. The biological sample for this research was obtained from calf thymus tissue. The natural compound pepstatin A has</p>

<p>Adenovirus E1A antibody was raised in sheep using GST-E1A fusion protein as the immunogen.</p>

<p>BNP-45 is a peptide that binds to the beta-subunit of the Na+/K+ ATPase, inhibiting its activity. It is a potent inhibitor of the enzyme and has been used in research as a tool to study ion channels and receptor activation.<br> BNP-45 has been shown to inhibit ion-channel activity by binding to the beta subunit of the Na+/K+ ATPase. This inhibition leads to an increase in intracellular sodium and calcium levels, which may result in a variety of physiological effects.</p>

<p>Voltage-dependent K+ channel opener; insulinotropic sulfonylurea receptor ligand</p>

<p>Uroguanylin (Human) product containing the disulfide bonds: Cys4-Cys12 and Cys7-Cys15 and avaialable in the trifluoroacetate salt form. Uroguanylin is a peptide hormone that is involved in the regulation of fluid and electrolyte balance in the body. It is produced in the intestinal tract, specifically in the lining of the small intestine and colon.<br>Uroguanylin belongs to a family of peptides that includes guanylin and the heat-stable enterotoxins (STs).These peptides all share a similar structure and function, as they bind to and activate the guanylate cyclase-C (GC-C) receptor in intestinal cells.<br>Activation of GC-C by uroguanylin leads to an increase in cyclic GMP (cGMP) levels, which in turn activates a variety of downstream signaling pathways. This leads to an increase in chloride and bicarbonate secretion in the intestine, as well as an increase in intestinal fluid secretion. Uroguanylin also stimulates sodium and water reabsorption in the kidneys, leading to an increase in urine output.<br>Uroguanylin has been studied for its potential therapeutic applications, particularly in the treatment of gastrointestinal disorders. For example, synthetic analogs of uroguanylin are being developed as potential treatments for constipation and other disorders of intestinal motility. Additionally, uroguanylin has been shown to have anti-inflammatory properties and may be useful in the treatment of inflammatory bowel disease.</p>

<p>Purified Human secretory IgA protein</p>

<p>H-EKIEELQQA-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EKIEELQQA-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EKIEELQQA-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EKIEELQQA-OH at the technical inquiry form on this page</p>

<p>HIV1 nef antibody was raised in mouse using HIV-1 nef (amino acids 163-173) as the immunogen.</p>

<p>Ac-Tyr-Val-Gly is a mitochondrial protein that regulates mitochondrial functions and is involved in the regulation of apoptosis. Ac-Tyr-Val-Gly interacts with nuclear DNA and regulates transcription, translation, and replication. Ac-Tyr-Val-Gly has been shown to be toxic to liver cells; however, it has been shown to have no effect on neuronal death or apoptosis pathway. These effects may be due to its ability to induce proteolytic activity in neurons and its ability to activate proapoptotic proteins such as Bax.</p>

<p>1,2,3,4-Tetra-O-acetyl-5-alkynyl-L-fucose is a per-O-acetylated version of 5-alkynyl-L-fucose, an inhibitor of the cellular fucosylation pathway. 1,2,3,4-Tetra-O-acetyl-5-alkynyl-L-fucose can pass through the eukaryotic cell membrane somewhat better than 5-alkynyl-L-fucose can itself, is deacetylated by cellular esterases and interferes with the biosynthesis of the fucosyl-donor and fucosyltransferase substrate GDP-Fuc, thus reducing fucosylation levels during glycoprotein biosynthesis.</p>

<p>Mouse anti Human IgG4 antibody</p>

<p>H-Val-Lys-Gly-Ile-Leu-Ser-NH2 is a biologically active peptide. It is a peptide that is derived from the amino acid sequence of protease activated receptor 2 (PAR2) and has been shown to induce coagulation. This peptide has also been shown to have cardiovascular effects, such as reducing blood pressure, and may be useful in the treatment of hypertension.</p>

<p>FTI 277 is a research tool that is used to study ion channels and protein interactions. It is an activator ligand that activates the receptor, which in turn promotes calcium release through the opening of ion channels. FTI 277 binds to the receptor and interacts with cell biology, such as the activation of antibody production. FTI 277 has been shown to inhibit the activity of peptides and proteins, such as calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP). It also inhibits the activity of an enzyme called acetylcholinesterase (AChE), which breaks down acetylcholine, a neurotransmitter.</p>

<p>Trofinetide is a neuroprotective compound that acts as an antioxidant. Trofinetide has been shown to reduce oxidative stress and protect against neuronal death in cells. It also has been shown to improve the clinical response in patients with Alzheimer's disease, and may be used for the treatment of other neurodegenerative disorders such as Parkinson's disease. Trofinetide is orally administered and is metabolized by cytochrome P450 enzymes, which makes it a suitable candidate for specific treatments. The pharmacokinetic properties of trofinetide are not well understood due to its short half-life.</p>

<p>Competitive oxytocin receptor antagonist. Inhibits oxytocin-induced uterine contractions in vitro and in in vivo models of preterm labor.  Acts via Gαi signalling and activates NF-κB and MAPK pathways to elicit proinflammatory effects in the amnion.</p>

<p>C-Reactive Protein (CRP), Highly Purified is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about C-Reactive Protein (CRP), Highly Purified including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>MK-5204 is a novel antifungal agent that has been shown to have broad-spectrum activity in vitro and in vivo against various human fungal pathogens, including Aspergillus fumigatus. The compound is a carboxamide derivative with an isopropyl group at the C2 position and a triazole at the C3 position. It has been shown to be orally active against murine Candida albicans infection. The structural modifications are designed to increase solubility, reduce toxicity, and improve pharmacokinetics. MK-5204 has completed the first phase of clinical development and is currently undergoing optimization for oral administration.<br>MK-5204 is being developed by Merck Research Laboratories.</p>

<p>Dnp-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(NMa)-NH2 is a synthetic peptide substrate that is used in the study of proteolytic enzymes. It has been shown to be an inhibitor of collagenase, MMPs, and stromelysin. This product can be used to determine the kinetic parameters for these enzymes. Dnp-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(NMa)-NH2 can be used as a substrate for enzyme catalysis studies, as well as for research on cancer and collagen.</p>

<p>Obatoclax mesylate is a synthetic small molecule, which is derived from chemical synthesis with a primary mode of action as a pan-BCL-2 inhibitor. This compound antagonizes multiple anti-apoptotic proteins within the BCL-2 family, ultimately promoting apoptosis in malignant cells. Its ability to inhibit these proteins disrupts the survival mechanisms that cancer cells exploit, potentially restoring apoptotic pathways that are often dysregulated in cancerous tissues.</p>

<p>CYP17 lyase inhibitor; androgen receptor antagonist</p>

<p>Inhibits proteosomes of class peptide epoxyketone; antineoplastic</p>

<p>Inhibitor of activin receptor-like kinases (ALK4, ALK5 and ALK7), members of TGFβ type I receptor family. Blocks activin- and TGFβ-mediated signaling and phosphorylation of Smad2 downstream. Suppresses tumor-promoting and tumor-suppressing effects of TGFβ. Promotes differentiation of human embryonic stem cells (hESCs), whilst sustaining mouse ESCs in the undifferentiated state.</p>

<p>H-AAKGRGAAL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AAKGRGAAL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AAKGRGAAL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AAKGRGAAL-OH at the technical inquiry form on this page</p>

<p>IL1a antibody is a monoclonal antibody that specifically targets interleukin-1 alpha (IL-1α), a pro-inflammatory cytokine involved in various inflammatory processes. This antibody is designed to neutralize the activity of IL-1α and has been shown to inhibit the formation of amyloid plaques, which are associated with neurodegenerative diseases such as Alzheimer's. IL1a antibody can also be used to detect autoantibodies in patient samples and has been used in research studies to investigate the role of IL-1α in diseases like atypical hemolytic uremic syndrome. Additionally, this antibody has been utilized for protein analysis techniques such as Western blotting and immunoprecipitation. With its high specificity and potency, IL1a antibody is a valuable tool for studying the function of IL-1α and its involvement in various disease pathways.</p>

<p>The CA 19-9 antibody is a highly specific monoclonal antibody that targets the biomolecule CA 19-9. This biomarker is commonly used in the field of Life Sciences for diagnostic purposes, especially in the detection and monitoring of certain cancers, including pancreatic, colorectal, and ovarian cancer. The CA 19-9 antibody binds to the glycoprotein CA 19-9 present on tumor cells, allowing for its detection through various immunoassay techniques.</p>

<p>Fmoc-Lys(Boc)-Rink-Amide MBHA Resin is a resin that is used in the synthesis of peptides.Crosslinkage (DVB): max 1%Swelling, DCM for 3min: ca 9ml/g</p>

<p>This product is an antiserum targeting amino acids 1-16 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms.</p>

<p>Acid Brown 121 is a disinfectant and sanitizer. It is a mixture of aromatic hydrocarbon, aliphatic hydrocarbon, and detergent compositions. Acid Brown 121 has been shown to be effective against Staphylococcus and endometriosis. It is also active against methicillin-resistant S. aureus strains, but not other bacteria such as Escherichia coli or Pseudomonas aeruginosa.</p>

<p>ALK receptor tyrosine kinase inhibitor</p>

<p>Rigosertib sodium is an experimental chemotherapeutic agent that is a derivative of benzyl styryl sulfone. It is synthesized chemically and functions primarily by inhibiting key signaling pathways involved in cancer cell proliferation. Specifically, Rigosertib targets the RAS signaling pathway along with the phosphatidylinositol-3-kinase/AKT and polo-like kinase 1 (Plk1) pathways, impeding the progression of the cell cycle and inducing apoptosis in malignant cells.</p>

<p>Tretinoin is a type of retinoic acid that can be used for the treatment of acne. It is a chemical inhibitor that binds to nuclear receptors and leads to an increase in apoptosis. This type of retinoic acid helps with cell detachment and increases shedding thus increasing cell turnover. Tretinoin has been shown to have antibacterial efficacy against Staphylococcus aureus, as well as synergistic effects when combined with other agents, such as cyclic lipopeptide antibiotics and quinolones. Additionally, Tretinoin is used in the research and treatment for promyelocytic leukaemia.</p>

<p>Pigment Yellow 126 is a nitro-fatty acid ester, which has an average particle diameter of 3.5 microns and a hydroxyl group at the terminal position of the molecule. This product can be used in coatings, plastics, paper, textiles, and paints. Pigment Yellow 126 is also used as a radiation absorber in x-ray films and fluorescent lamps. This product reacts with deionized water to form fatty acids and aliphatic hydrocarbons.</p>

<p>H-VLVEVLADPLDHR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VLVEVLADPLDHR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VLVEVLADPLDHR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VLVEVLADPLDHR-OH at the technical inquiry form on this page</p>

<p>H-PVYIYFNTWTTC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-PVYIYFNTWTTC-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-PVYIYFNTWTTC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-PVYIYFNTWTTC-NH2 at the technical inquiry form on this page</p>

<p>Peptide LCBiot-SGRGKGGKGLGKGGAKRHRKV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Ac-Phe-Thiaphe-OH is a molecule that inhibits the activity of nerve growth factor (NGF) by binding to the NGF receptor. It has been shown to be effective in reducing oxidative stress and nerve injury. Ac-Phe-Thiaphe-OH also has a molecular target for cancer, as it binds to the epidermal growth factor receptor and blocks the epidermal growth factor from binding to the receptor. This leads to a decrease in cancer cell proliferation and an increase in apoptosis. Ac-Phe-Thiaphe-OH also binds to serotonin receptors and reduces pancreatic cancer cells in culture. The molecule is currently under development as a potential treatment for pancreatic cancer.</p>

<p>H-ß-Ala-2-ClTrt-Resin (200-400 mesh) 1% DVB is a building block for peptide synthesis. It is a resin that contains amines and thiols. H-ß-Ala-2-ClTrt-Resin (200-400 mesh) 1% DVB also has the tools for peptide synthesis, such as alcohols and resins.</p>

<p>Cytokeratin 8 is a human protein that is encoded by the KRT8 gene. It is a type I transmembrane protein that consists of three alpha-helical domains. Cytokeratin 8 has been shown to be involved in the regulation of keratinocyte migration, differentiation and proliferation. Recombinant human cytokeratin 8 is produced using Escherichia coli as a host cell. The recombinant form of this protein can be used to study cytokeratin 8's role in cellular processes.</p>

<p>Abiraterone is an anti-cancer drug that has been shown to be effective in treating prostate cancer. It works by blocking the production of testosterone by inhibiting androgen synthesis. Abiraterone does this by inhibiting CYP17A1, which converts cholesterol into pregnenolone, and then into progesterone and testosterone. Furthermore, it binds to the enzyme steroid 5-alpha reductase, which converts testosterone into dihydrotestosterone (DHT). Abiraterone is usually a last resort for patients who have stopped responding to other lines of hormone therapies, which is known as second-line therapy.</p>

<p>Nesfatin-1 Like Peptide (Mouse) is a peptide that regulates feeding behavior and insulin secretion. It is an insulinotropic peptide, which means it stimulates the release of insulin from pancreatic beta cells. Nesfatin-1 Like Peptide (Mouse) has been shown to be upregulated in the hypothalamus during fasting, thereby regulating feeding behavior. This peptide also has neurologic effects, such as stimulating locomotor activity, and may have antiinflammatory effects.</p>

<p>Please enquire for more information about Reactive red 230 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Diclazuril chemical reference substance</p>

<p>IgG Fc antibody was raised in mouse using immunoglobulin G Fc region as the immunogen.</p>

<p>H-YSNFDVATHVPLIFYVPGR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-YSNFDVATHVPLIFYVPGR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-YSNFDVATHVPLIFYVPGR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-YSNFDVATHVPLIFYVPGR-OH at the technical inquiry form on this page</p>

<p>β3-adrenoceptor agonist</p>