Antibiotiques

Sulfasalazine is a disease-modifying anti-rheumatic drug (DMARD) with action on reducing inflammation and immune system activity and is used for treating rheumatoid arthritis and inflammatory bowel disease.

Inhibitor of protein synthesis; aminoglycoside

Teicoplanin is related to vancomycin and has similar effects against gram-positive bacteria and anaerobes, and usually requires less frequent administration than vancomycin, but it is less efficient against S. haemolyticus. Due its size and polarity, teicoplanin can’t pass through the membrane of gram-negative bacteria thus it is not active against them. It is used to treat severe infections such as septicemia, endocarditis, bone and joint infections.

Netilmicin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis by binding to the 30S ribosomal subunit and is used for treating severe bacterial infections.

Bedaquiline fumarate is the salt form of bedaquiline, a diarylquinoline molecule with an ATP synthetase inhibitory activity. Bedaquiline fumarate is an FDA-approved drug for the oral treatment of multidrug-resistant tuberculosis. Bedaquiline fumarate acts by inhibiting the activity of the ATP synthetase in the pathogenic bacterium Mycobacterium tuberculosis, even in the case of multiple antibiotic resistant strains.

Inhibitor of DNA replication; inhibitor of theophylline and caffeine metabolism

A fluoroquinolone antibiotic which inhibits nucleic acid synthesis by targeting the DNA gyrase and topoisomerase IV. This second-generation fluoroquinolone has a broad spectrum of action and is more effective against Gram-negative bacteria.

Cefpodoxime proxetil is a prodrug of cefpodoxime with action on bacterial cell wall synthesis and is used for treating bacterial infections such as pneumonia, bronchitis, and gonorrhea.