Anticorps pour la recherche sur le cancer

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-9. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IL-9. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-9, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IL-9. You can calculate the concentration of Mouse IL-9 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-6. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IL-6. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IL-6. You can calculate the concentration of Human IL-6 in the samples by comparing the OD of the samples to the standard curve.

<p>Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.</p>

<p>Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-</p>

<p>SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).</p>

<p>Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.</p>

<p>Umbralisib (TGR 1202) is a PI3Kδ inhibitor.</p>

<p>TDO inhibitor; IC50: human 0.62 μM, mouse 2 μM; selective over IDO, MAOs; hinders TDO+ tumor growth in mice; orally active.</p>

<p>Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.</p>

<p>Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr</p>

<p>Maleimide surface group on nanoparticles allows simple conjugation with peptides via click chemistry, preserving biofunctions.</p>

<p>BSJ-4-116: potent, selective CDK12 PROTAC, IC50 = 6 nM; downregulates DDR genes, induces premature transcription termination.</p>

<p>Xanthatin exhibits cytotoxic, antibacterial, antifungal properties, may treat NSCLC, and inhibits melanoma by targeting Wnt/β-catenin and angiogenesis.</p>

<p>Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).</p>

<p>Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.</p>

<p>GW779439X is an inhibitor of CDK.</p>

<p>UC2288, a Sorafenib-based p21 attenuator, reduces p21 levels without affecting its stability.</p>

<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>

<p>Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.</p>

<p>CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor.</p>

<p>Syrosingopine is a dual inhibitor of MCT1 and MCT4, 60 times more potent against MCT4, preventing lactate and H+ efflux.Cost-effective and quality-assured.</p>

<p>BI 6015 is an antagonist of HNF4α. HNF4α is a nuclear receptor that regulates gene expression in the intestine cells, liver cells, and pancreas-β cells.</p>

<p>BMS-265246 is a potent and selective CDK1/2 inhibitor.</p>

<p>C-7280948 is a PRMT1 inhibitor.</p>

<p>MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.</p>

<p>KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.</p>

<p>Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.</p>

<p>VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor.Cost-effective and quality-assured.</p>

<p>6-Methoxydihydrosanguinarine: cytotoxic to MCF-7/SF-268 cells, IC50 of 0.61/0.54 μM; fights MRSA, MIC 1.9-3.9 μg/ml.</p>

<p>GNF-5, non-ATP Bcr-Abl inhibitor (IC50: 0.22±0.1 uM, wild-type), improves upon GNF-2 with better pharmacokinetics.</p>

<p>MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met).</p>

<p>SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y</p>

<p>Acetylalkannin (Alkannin acetate), an isohexenylnaphthazarin pigment extracted from Arnebia euchroma, exhibits antimicrobial and cytotoxic properties.</p>

<p>Murrayone from M. paniculata, a bioactive coumarin, prevents cancer metastasis and reduces ADP-induced platelet aggregation.</p>

<p>Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.</p>

<p>Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR).</p>

<p>OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor.</p>

<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>

<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>

<p>Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.</p>

<p>MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.</p>

<p>JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR). JNJ-63576253 can be used for the research of CRPC.</p>

<p>BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.</p>

<p>Pitstop2 is an amphipathic protein-bound inhibitor of the clathrin terminal domain. Pitstop2 has antitumor activity. Cost-effective, quality assurance.</p>

<p>CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity</p>

<p>ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity</p>

<p>Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury</p>

<p>Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.</p>

<p>YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.</p>

<p>MTOB, a CtBP substrate, inhibits CtBP-linked cancer activity in cells/mice and regulates TCF-4, affecting CSC proliferation.</p>

<p>RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.</p>

<p>Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.</p>

<p>CTX-0294885, a bisanilino pyrimidine, inhibits many kinases; used for Sepharose-based kinase capture.</p>

<p>Desmethylanethol trithione (ADT-OH), a synthetic H2S donor, modulates tPA effects, reduces stroke damage, and improves recovery in mice.</p>

<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>

Niraparib (MK-4827), a PARP inhibitor, boosts DNA breaks to trigger genomic instability and apoptosis, offering anti-cancer effects.

<p>M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.</p>

<p>Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP, binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3.</p>

<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>

<p>5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product.</p>

<p>Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent</p>

<p>ZCL278 is a selective Cdc42 GTPase inhibitor.</p>

<p>Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3.</p>

<p>FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)</p>

<p>Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.</p>

<p>CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.</p>

<p>Cidofovir dihydrate: Injectable anti-CMV; suppresses CMV by inhibiting viral DNA polymerase; treats CMV retinitis in AIDS.</p>

<p>(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.</p>

<p>TD52, an Erlotinib derivative, is an oral CIP2A cancer inhibitor that disrupts Elk1's attachment to the CIP2A promoter.</p>

<p>2-NP is a STAT1 enhancer.</p>

<p>SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.</p>

<p>Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3</p>

<p>Paederoside deters beetles, isolated from aphids, and inhibits tumor-promotion in Epstein-Barr virus.</p>

<p>FLTX1, a Tamoxifen derivative, fluoresces to mark estrogen receptors and acts as a strong antiestrogen in breast cancer without affecting the uterus.</p>

<p>Goserelin acetate (Fertilan) is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer.</p>

<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>

<p>DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.</p>

<p>NS1619 have cardio-protective effects after ischemia-reperfusion injury.</p>

<p>Kumatakenin can suppress &gt;80% of the SOS-inducing activity of Trp-P-1 at &lt;0.06 micromol/mL.</p>

<p>CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest &amp; DNA damage.</p>

<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>

<p>Polyporenic acid C shows inhibitory activity against human collagenase.</p>

<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>

<p>Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.</p>

<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>

<p>Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor.</p>

<p>Rasarfin inhibits Ras and ARF6.</p>

<p>UUN44923: FTO inhibitor, potential treatment for obesity, MS, T2D, Alzheimer's, various cancers.</p>

<p>NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.</p>

<p>Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo.</p>

<p>HNHA is an inhibitor of HDAC.</p>

<p>TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.</p>

<p>Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra</p>

<p>Aloesin, a C-glycosylated chromone from aloe, blocks tyrosinase (IC50=0.9mM) in melanin production.</p>

<p>β-Damascone are a series of closely related chemical compounds that are components of a variety of essential oils.</p>

<p>LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>

<p>GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).</p>

<p>Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and</p>

<p>Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is &gt;200-fold higher for Aurora A than Aurora B.</p>

<p>O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.</p>