Hétérocycles azotés (N)

Applications 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one (cas# 545445-44-1) is a useful research chemical.

Impurity Azathioprine EP Impurity C
Applications 5-Chloro-1-methyl-4-nitroimidazole (cas# 4897-25-0) is a compound useful in organic synthesis.

Applications 5-Benzylthio-1H-tetrazole is used in the preparation of organosilicon compounds that have antibacterial activity.
References Baghershiroudi, Mahrokh. et al., J. IRAN. CHEM. SOC. 15,1279-1286(2018);

Applications An intermediate in the preparation of Piperidinyloxy free radical derivatives.
References Irie, O., et al.: Bioorg. Med. Chem. Lett., 18, 5280 (2008),

Applications Labelled Benzotriazole. BT is an anticorrosive agent well known for its use in aircraft deicing and antifreeze fluids but also used in dishwasher detergents. Benzotriazole is antiestrogenic in vitro but not in vivo.Isotopic purity: 97% d4, 3% d3.
References Rollinson, G., et al.: Biotechnol. Lett., 8, 303 (1986), Cancilla, D., et al.: Environ. Toxicol. Chem., 16, 430 (1997), Beresford, N., et al.: Toxicol. Appl. Pharmacol., 162, 22 (2000), Cornell, J., et al.: Environ. Toxicol. Chem., 19, 1465 (2000), Giger, W., et al.: Environ. Sci. Technol., 40, 7186 (2006),

Applications (2-oxo-4-phenylpyrrolidin-1-yl)acetic Acid (cas# 67118-34-7) is a useful research chemical.

Applications 5-[bis(2-chloroethyl)amino]pyrimidine-2,4-diol (cas# 66-75-1) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Vinylpyridine is used as a reagent in the synthesis of 4,4'-[9H-Carbazole-3,6-diyldi-(1E)-2,1-ethenediyl]bis[1-methyl-pyridinium Diiodide (C176070); a human quadruplex DNA stabilizer and telomerase inhibitor. 4-Vinylpyridine is also used as a reagent in the synthesis of spiro[cyclopropane[3H]indol]ones as polo-like kinase 4 inhibitors and orally bioavailable antitumor agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yang, D., et al.: J. Phys. Chem. A, 111, 9224 (2007); Chang, C., et al.: J. Chin. Chem. Soc-Taip., 50, 185 (2003); Sampson, P.B., et al.: J. Med. Chem., no vol., no pp., (2014 ahead of print)

Applications 3,4-Diaminopyridine-d3 is the deuterium labelled analog of the drug 3,4-Diaminopyridine (D415950), which is used as a reagent in the preparation of 9-deazaxanthine derivatives which has activity as dual A2A antagonists/MAO-B inhibitors with potential as anti-Parkinson's agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rivara, S., et al.: J. Med. Chem., 56, 1247 (2013)

Applications Used for preparation of thieno-tetrahydropyridines useful as class III antiarrhythmic agents.
References Bahekar, R., et al.: Bioorg. Med. Chem., 15, 5950 (2007), Hayakawa, M., et al.: Bioorg. Med. Chem. Lett., 17, 2438 (2007),

Applications 5-Aminomethyl-2-chloropyridine is a reagent that is used in the synthesis of macamides and analogs that have FAAH (fatty acid amide hydrolase) inhibitory activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wu, H., et al.: Bioorg. Med. Chem., 21, 5188 (2013);

Applications 2,4,6-Tris(pentadecafluoroheptyl)-1,3,5-triazine (CAS# 21674-38-4) is an s-triazine derivative (T773008) and is used as a reference standard in mass spectroscopy for m/z ratios between 600-1600.
References Aczel, T.; et al.: Anal. Chem., 40, 1917 (1968);

Applications 1-Formylpiperazine (cas# 7755-92-2) is a useful research chemical.

Applications 2-Phenyl-1H-benzimidazole is a reagent used in the synthesis of various aryl-substituted benzimidazole derivatives. Also used in the synthesis of benzimidazole and quinocaline derivatives
References Saleh, V. et al.: Org. Chem. Int., 1, (2015); Hasanpour, M. et al.: J. Chin. CHem. Soc., 62, 412 (2015);

Applications 2,5,6-Triaminopyrimidin-4(1H)-one sulphate (cas# 39267-74-8) is a useful research chemical.

Stability Hygroscopic
Applications 1-Ethyl-5-hydroxy-2-pyrrolidinone is an important organic solvent used in varnishing. Industrial solvent.
References Koch, H. et al. Arch. Toxicol., 88, 893 (2014); Koslitz, S. et al.: Toxicol. Lett., 231, 142 (2014);

Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);

Applications 1,2-Bis(2-(4,5-dihydro-1H-imidazol-2-yl)propan-2-yl)diazene Dihydrochloride is used as an initiator in the synthesis of ultra heigh relative molecular mass polyarcrylamide.
References Wang, L., et. al.: Hecheng Shuzhi Ji Suliao, 31, 37 (2014)

Applications 2-(4,6-Diphenyl-1,3,5-triazine-2-yl)-5-[(hexyl)oxy]phenol is used as a light stabilizer/UV absorber for polyethylene phthalate polymers intended for use in contact with food.
References Food and Drug Administration, HHS: Fed. Reg., 63, 43874 (1998); Fechine, G.J.M. et al.: Polym. Degrad. Stab., 75, 153 (2002);

Applications 3-Amino-6-chloropyridazine (cas# 5469-69-2) is a compound useful in organic synthesis.

Applications 2,4-Dihydroxypyrrolo[2,3-d]pyrimidine (cas# 39929-79-8) is a compound useful in organic synthesis.

Applications 1-(9-Fluorenylmethyl)piperidine is an intermediate when synthesizing 9-​Fluorenylmethoxycarbonyl group (FMOC), which is a new amino-protecting group.
References Carpino, L., et al.: J. Org. Chem., 37, 3404 (1972)

Applications 1,2-Dimethyl-1H-imidazole-5-sulphonyl Chloride (cas# 849351-92-4) is a useful research chemical.

Applications 1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole (cas# 212248-62-9) is a useful research chemical.

Applications A nitro substituted piperazine.

Applications Vardenafil oxopiperazine-D6 is a labelled analogue of Vardenafil oxopiperazine (V098030)

Applications N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.
References Kwon, Y.E. et al.: Bioorg. Med. Chem., 15, 6596 (2007); Knutsen, L.J.S. et al.: J. Med. Chem., 42, 3463 (1999);

Impurity Flecainide EP Impurity B
Applications 2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.
References Reddy, G. et al.: Hetero. Chem., 23, 247 (2012); Fujita, M. et al.: Chem. Pharm. Bull., 46, 787 (1998);

Applications 2-Hydrazino-1,3-benzoxazole

Applications Oxidation and chlorination reagent.

Applications 4-(4-Chlorophenyl)-4-hydroxypiperidine (cas# 39512-49-7) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 4-Aminopyridine N-Oxide (cas# 3535-75-9) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Impurity Droperidol Impurity 4
Applications 4-(2-Nitroanilino)pyridine can be used to increase the yield of 4-(2-Aminoanilino)pyridine (A583160) dihydrochloride by hydrogenation in the presence of a Ni-Cr catalyst. Droperidol Impurity 4.
References Avots, A., et al.: U.S.S.R., SU 1318592 A1 19870623

Applications Methyl 5-Ethyl-2-pyridine-carboxylate (cas# 13509-14-3) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Pyridine-2-aldoxime (cas# 873-69-8) is a useful research chemical.

Impurity Carglumic Acid Impurity B
Applications 3-(2,5-Dioxoimidazolidin-4-yl)propanoic Acid is defined as combinational markers to distinguish hepatocellular carcinoma (HCC) from cirrhosis (CIR).
References Shao, Y., et al.: J. Proteome Res., 14, 906-916 (2015)

Applications 1-(4-Hydroxyphenyl)piperazine

Applications 1-Piperidin-2-ylacetone Hydrochloride is an intermediate used in the synthesis of 1-Piperidin-2-ylacetone (B449983), which is a useful research chemical.

Applications 3-Chloro-6-phenylpyridazine (cas# 20375-65-9) is a useful research chemical.

Applications 2-Chloropyridine (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during the decomposition of specific insecticides. 2-CPY was found to be genotoxic agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Demsia, G., et al.: Mutat. Res., 634, 32 (2007), Stapleton, D., et al.: Water Res., 43, 3964 (2009),

Applications 1H-1,2,4-triazol-5-ol (cas# 930-33-6) is a useful research chemical.

Applications 6-Hydroxy-2,4,5-triaminopyrimidine, Sulfate (cas# 35011-47-3) is a compound useful in organic synthesis.

Applications Borane-​2-​methylpyridine Complex is a reducing agent which may be used in the synthesis of deoxy0RNA substrates with use towards organic resistive memory devices.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shih, C. et al.: Chem. Comm., 52, 13463 (2016);

Applications 5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Stability Hygroscopic
Applications 4-Hydroxy-1,1-dimethylpiperidinium Bromide is a derivative of 4-Hydroxypiperidine (H950845); a reagent used for the synthesis of Acridine (A190900) derivatives and fibrinogen receptor antagonists.
References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999)

Applications Anti-bacterial agent.
References Banfi, E., et al.: J. Chemotherapy, 5(3), 164 (1993),

Applications 4-Chloro-3-pyridinesulfonamide is a building block that has been used as a reactant for the preparation of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives as inhibitors of four isoforms of zinc enzyme carbonic anhydrase.
References Slawinski, J., et. al.: Eur. J. Med. Chem., 69, 701 (2013)

Applications 3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.
References Kronke, J., et al.: Nature 523, 183 (2015); Liu C., et al.: Faming Zhuanli Shenqing CN 105348257 A 20160224 (2016); Rao, R., et al. : PCT Int. Appl. WO 2016024286 A2 20160218 (2016)

Applications 6-(Dibutylamino)-1,3,5-triazine-2,4-dithiol (cas# 29529-99-5) is a useful research chemical.

Applications 4-Acetylpyridine is a acetylated pyridine used in the preparation of nitrogen containing bicyclic heterocycles and other organic compounds. 4-Acetylpyridine is also present in mainstream cigarette smoke.
References Kulshreshtha, N.P. et al.: J. Chrom. A, 985, 303 (2003); Scian, M. et al.: Inhal. Toxicol., 21, 1040 (2009);