Hétérocycles azotés (N)

Applications 6-phenyl-1,3,5-triazine-2,4-diamine (cas# 91-76-9) is a useful research chemical.

Applications 2,6-diethylpyrazine (cas# 13067-27-1) is a useful research chemical.

Applications An Intermediate in the synthesis of risperidone and iloperidone.

Applications 1,2,3,6-Tetrahydropyridine (cas# 694-05-3) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 5-(4-Chlorobutyl)-1-cyclohexyltetrazole-d11 (cas# 1073608-19-1) is a compound useful in organic synthesis.

Applications 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is used in the preparation of blue pyrrole dyes. 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is also used as an intermediate in the synthesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.
References Treibs, A. et al.: Lieb. Ann. Chem., 2, 289 (1978); Elsinghorst, P. et al.: J. Lab. Comp. Radiopharm., 52, 360 (2009);

Applications 1-Isopropenyl-2-benzimidazolidinone (cas# 52099-72-6) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Butyl-5-chloro-1H-imidazole (cas# 158365-99-2) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Light Sensitive, Decomposes Rapidly in Air, Temperature Sensitive
Applications It has been examined as a ligand and as a pseudo-cyanide.

Applications 2-Amino-5-pyrimidinol (cas# 143489-45-6) is a compound useful in organic synthesis.

Impurity Terazosin EP Impurity M
Applications 1,4-Di-2-furoyl-piperazine (Terazosin EP Impurity M) can be used in biological studies to examine the relationship of structure to parasiticide activity of nitrated derivatives.
References Cavier, R., et al.: Chimica Therapeutica 5, 270 (1970)

Applications 2-(Ethylthio)-1H-benzimidazole is the active substance or the active ingredient in the synthesis of the drug Metaprot. Performs a transplacental function: daily administration of bemithyl (20 mg/kg) from 6 th to 16 th day of pregnancy in female rats led to the decrease in fetal death after the implantation and increased fetal body weight.
References Kibal'chich, D. A., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 74, 30 (2011); Bugaeva, L. I., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 70, 40 (2007).

Applications 2-Chloro-4,6-dimethoxy-1,3,5-triazine (cas# 3140-73-6) is a compound useful in organic synthesis.

Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol is used as a reagent in the synthesis of Medetomidine (M203250); an α2-adrenergic agonist. Also a sedative and analgesic.
References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010

Applications 1-(4-Hydroxyphenyl)piperazine

Applications 4-Benzylpyridine is a benzylpyridine with antifungal properties. 4-Benzylpyridine has been used as a reactant in the synthesis of bis(alkylpyridinium)alkanes as antifungal agents.
References Takeshiba, H. et al.: Sank. Kenk. Nen., 23, 225 (1971)

Impurity Pantoprazole EP Impurity C; Pantoprazole USP Related Compound C
Applications Pantoprazole EP Impurity C. Pantoprazole USP Related Compound C.

Stability Hygroscopic
Applications 4-Diphenylmethoxypiperidine, HCl

Applications 5-[bis(2-chloroethyl)amino]pyrimidine-2,4-diol (cas# 66-75-1) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1-(2,3-Epoxypropyl)-2-nitroimidazole is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.
References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)

Applications 3-Aminopiperidine DiHCl can be used as reactant/reagent for xanthine dipeptidyl peptidase inhibitors for treatment of type 2 diabetes.
References Eckhardt, M., et al.: J Med Chem, 50, 6450 (2007)

Applications Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.
References Stubbins, J. et al.: Eur. J. Med. Chem., 14, 219 (1979);

Impurity Azathioprine EP Impurity C
Applications 5-Chloro-1-methyl-4-nitroimidazole (cas# 4897-25-0) is a compound useful in organic synthesis.

Applications An intermediate in the synthesis of Prasugrel (P701150).

Applications 6-amino-5-chloro-2-cyclopropylpyrimidine-4-carboxylic Acid (cas# 858956-08-8) is a useful research chemical.

Applications An intermediate in the preparation of 4-Amino-2,2,6,6-tetra-methyl Piperidine-1-oxyl.
References Li, W., et al.: J. Pharm. Pharmacol., 58, 941 (2006),

Applications Piperonylic Acid is a compound closely mimicking the structure of transcinnamic acid involved in the phenylpropanoid pathway in plant physiology.
References Schalk, M. et al.: Plant Physiol., 118, 209 (1998);

Applications 4-Aminopiperidine is a useful reactant in organic synthesis.
References Park, Sun Jun, et al.: Bioorg. & Med. Chem. Let., 27(18), 4399-4404 (2017);Le Manach, Claire, et al.: J. of Med. Chem., 59(21), 9890-9905 (2016)

Applications N-Benzyl-4-carboethoxypiperidine (cas# 24228-40-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.
References Northrup, A. et al.: J. Med. Chem., 56, 2294 (2013);

Applications 5-Bromo-2,4-diamino-6-hydroxypyrimidine (cas# 6312-72-7) is a compound useful in organic synthesis.

Applications 3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol.
References Hojati, S. F., et al.: Can. J. Chem., 88, 135 (2010);

Applications 6,7-Dimethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one is an analogue of Terazosin (T105000), an α-1-adrenergicblocker related to prazosin (P702325).
References Patterson, S.E., et al.: J. Chromatog., 311, 206 (1984), Fort, F.L., et al.: Drug Chem. Toxicol., 7, 435 (1984), Lepor, H., et al.: J. Urol., 148, 1467 (1992),

Applications (αR)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxy-benzeneacetic Acid is an intermediate used to prepare Cephalosporin derivatives with activities against both Gram-positive and Gram-negative bacteria.
References Albrecht, H., et al.: J. Med. Chem., 37, 400 (1994)

Applications rac-trans-2,5-Dimethyl-3-(2-methylphenyl)-1-propylimidazolini-4-one Hydrochloride is the salt analogue of 2,5-Dimethyl-3-(2-methylphenyl)-1-propylimidazolini-4-one (D477055), an impurity of Prilocaine (Prilocaine Hydrochloride P725000). Prilocaine is a local anesthetic of the amino amide type and is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA) towards the treatment of conditions like paresthesia.
References Caliaro, G., et al.: J. Pharm. Biomed. Anal., 26, 427 (2001), Ulmeanu, S., et al.: Pharm. Res., 20, 1317 (2003)

Applications 1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole (cas# 212248-62-9) is a useful research chemical.

Applications 2-Amino-3,5-dibromopyrazine is used in the preparation of conjugated polymers for neurotoxin detection. 2-Amino-3,5-dibromopyrazine is an intermediate in the preparation of rho kinase (ROCK) inhibitors.
References Thomas, J. et al.: Polym. Prepr., 46, 1211 (2005); Henderson, A.J. et al.: Bioorg. Med. Chem. Lett., 20, 1137 (2010);

Applications 3-Aminopiperidin-2-one hydrochloride (cas# 138377-80-7) is a useful research chemical.

Applications 3-(Methoxycarbonyl)pyridine-5-boronic acid, pinacol ester

Applications An intermediate in the synthesis of rabeprazole (R070500).

Stability Hygroscopic
Applications 1H-Pyrrolo[3,2-b]pyridine-2,3-dione (cas# 153072-89-0) is a useful research chemical.

Applications 4-Cyanopyridine is a reagent for the synthesis of 1-tolyl-5-benzylthiotetrazole and 2-hexylthio-4-pyridinecarbonitrile, an antituberculotics. Preparation of the antihypertensive agent Pinacidil using the chemoselective and green oxidative rearrangement of an amidine and addition of an amine to a guanidine as the key step. Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking. Human L-xylulose reductase (XR) is an enzyme of the glucuronic acid/uronate cycle of glucose metabolism with the possible target for treatment of the long-term complications of diabetes.
References Waisser, K., et al.: Folia Pharmaceutica Universitatis Carolinae, 18, 31 (1995); Carbone, V., et al.: Bioorg. Med. Chem., 13, 301 (2004); Baeten, M., et al.: Adv. Synth. Catal., 358, 826 (2016)

Applications Succinimide is a reagent that is used in the synthesis of Lumiflavin (L473900), which is a toxic photolysis product of vitamin B2 (R415000).
References Zhao, X. et al.: Chemosphere, 63, 1116 (2006); Litke, S.V. et al.: Khim. Fiz., 10, 48 (1991); Ye, W. et al.: Guang. Yaox. Xueb., 12, 175 (1996);

Applications 5-Chlorobenzotriazole is a good inhibitor; it decreases anodic and cathodic reaction rates, and the highest inhibition efficiency was 91.2%. The inhibitory effect of 5-chlorobenzotriazole is explained by the formation of the layer on the copper surface.
References Simonovic, Ana T., et al.: ACS Omeg., 5, 12832-12841 (2020);

Applications Vardenafil oxopiperazine-D6 is a labelled analogue of Vardenafil oxopiperazine (V098030)

Applications 3,5-Dimethyl-4-nitropyridine 1-Oxide is an intermediate used to prepare 2-[(2-pyridylmethyl)thio or -sulfinyl]benzimidazoles as antiulcer agents.
References Nohara, A., et al.: U.S., US 4689333 A 19870825. (1987)

Applications 6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]-triazolium chloride (cas# 153851-71-9) is a useful research chemical.