Hétérocycles azotés (N)

Applications An impurity arising in the synthesis of zoledronic acid (Z623500).

Applications 2-Chloro-4,6-dimethoxy-1,3,5-triazine (cas# 3140-73-6) is a compound useful in organic synthesis.

Applications (3-Chloropyrazin-2-yl)methanol (cas# 89283-32-9) is a useful reagent for the preparation of indazolylquinazolinones as inhibitors of human immunodeficiency virus replication.
References Gillis, E. P., et al.: PCT Int. Appl. (2020), WO 2020084492 A1

Applications Hydrocinnamic Acid N-Hydroxysuccinimide Ester (cas# 109318-10-7) is a compound useful in organic synthesis.

Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.
References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);

Applications 6-phenyl-1,3,5-triazine-2,4-diamine (cas# 91-76-9) is a useful research chemical.

Applications 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a reagent in the synthesis and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone which is an antibacterial agent. Benzoxazinyl-oxazolidinone had potent activity against Gram-positive pathogens. 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is also an intermediate in the synthesis of Tedizolid (T013750).
References Xin, Q., et al.: J. Med. Chem., 54, 7493 (2011)

Applications 1-Formylpiperazine (cas# 7755-92-2) is a useful research chemical.

Stability Light Sensitive
Applications 1-[4-bromo-2-(trifluoromethyl)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (cas# 1179507-09-5) is a useful research chemical.

Applications 1-Piperidin-2-ylacetone Hydrochloride is an intermediate used in the synthesis of 1-Piperidin-2-ylacetone (B449983), which is a useful research chemical.

Applications 5-[1-(Methylthio)ethyl]-2-trifluoromethylpyridine is an intermediate in the synthesis of Sulfoxaflor (S755005), a novel pesticide of the sulfoximine group and the only sulfoximine class of pesticide that act on the central nervous system.
References Sparks, T.C., et al. Pestic. Biochem. Physiol., 107, 1 (2013);

Stability Hygroscopic
Applications 1H-Pyrrolo[3,2-b]pyridine-2,3-dione (cas# 153072-89-0) is a useful research chemical.

Applications 5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Applications 3-(4-iodo-1H-pyrazol-1-yl)propanenitrile (cas# 88393-88-8) is a useful research chemical.

Applications 3,4-Dimethylpyrazole (cas# 2820-37-3) is a compound useful in organic synthesis.

Applications 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is used in preparation and structure of alkaline earth iodide phosphine oxide and urea complexes as reactant or reagents.
References Fitts, Lacey S., et al.: New J. of Chem., (2016); Hall, Jessica E., et al.: Angew. Chem. Int. Ed., 55, 11153-11157 (2016)

Applications 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one (cas# 545445-44-1) is a useful research chemical.

Applications Vardenafil oxopiperazine-D6 is a labelled analogue of Vardenafil oxopiperazine (V098030)

Applications 6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]-triazolium chloride (cas# 153851-71-9) is a useful research chemical.

Applications 2-Amino-4-hydroxy-6-chloro-s-triazine is an aromatic intermediate compound useful for the preparation of substituted melamine, ammelides, and ammelines.
References Hapeman, C., et al.: J. Agric. Food Chem., 43, 1383 (1995), Garcia-Montano, J., et al.: Environ. Sci. Technol., 42, 6663 (2008),

Applications Tolyltriazole acts as a corrosive inhibitor and is used as corrosion protection on top of metals such as copper.
References Hseih, M. et al.: Ind. Eng. Chem. Res., 49, 7313 (2010);

Applications (αR)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxy-benzeneacetic Acid is an intermediate used to prepare Cephalosporin derivatives with activities against both Gram-positive and Gram-negative bacteria.
References Albrecht, H., et al.: J. Med. Chem., 37, 400 (1994)

Impurity Pantoprazole EP Impurity C; Pantoprazole USP Related Compound C
Applications Pantoprazole EP Impurity C. Pantoprazole USP Related Compound C.

Applications An intermediate in the preparation of Piperidinyloxy free radical derivatives.
References Irie, O., et al.: Bioorg. Med. Chem. Lett., 18, 5280 (2008),

Applications 1H-1,2,3-Triazole-1-acetic acid (cas# 4314-22-1) is a useful research chemical.

Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);

Applications The most characteristic degrdadation product of melanins. An important biomarker for Melatonin (M215000) metabolism.
References Shen, X., et al.: J. Med. Chem., 39, 2018 (1996), Xin, W., et a: Chem. Res. Toxicol., 13, 749 (2000), An, L., et al.: Food Chem. Toxicol., 44, 436 (2006),

Applications 3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol.
References Hojati, S. F., et al.: Can. J. Chem., 88, 135 (2010);

Applications 2,2,6,6-Tetramethyl-1-hydroxypiperidine is a reactant used in various synthesis and investigations. It was used as a reactant in the study of predicting organic hydrogen atom transfer rate constants using the Marcus cross relation. 2,2,6,6-Tetramethyl-1-hydroxypiperidine was also used as a reactant in the preparation of ammonia from an iron nitrido complex.
References Scepaniak, J., et al.: Angew. Chem. Int. Ed., 48, 3158 (2009); Warren, J., Mayer, J.: Proc. Natl. Acad. Sci. U.S.A., 107, 5282 (2010);

Applications 2-Chloropyridine (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during the decomposition of specific insecticides. 2-CPY was found to be genotoxic agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Demsia, G., et al.: Mutat. Res., 634, 32 (2007), Stapleton, D., et al.: Water Res., 43, 3964 (2009),

Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.

Applications 2-Aminopyridine (D6, 98%) (cas# 203784-57-0) is a useful research chemical.

Applications 2-Nitrosopyridine is a useful reactant in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, Xing, et al.: J. of Org. Chem., 84(7), 4402-4412 (2019);Zhang, Jingchuan, et al.: Chem. - A Euro. J., 24(17), 4289-4293 (2018)

Applications 2-Amino-4,6-dimethylpyrimidine is a bioactive compound.
References Phan, D. C., et al.: Hoa Hoc Va Cong Nghiep Hoa Chat, 8, 30 (2001); Shen, Z., et al.: Yingyong Huagong, 37, 721 (2008)

Applications 2-Phenyl-1H-benzimidazole is a reagent used in the synthesis of various aryl-substituted benzimidazole derivatives. Also used in the synthesis of benzimidazole and quinocaline derivatives
References Saleh, V. et al.: Org. Chem. Int., 1, (2015); Hasanpour, M. et al.: J. Chin. CHem. Soc., 62, 412 (2015);

Applications 1,4-Bis(3-chlorophenyl)-piperazine acts as a reagent in the preparation of diarylalkylene diamines and N, N’,N’’-triaryldialkylene triamines.
References Mohr, R., et al.: From Eur. Pat. Appl. (1981), EP 31089 A1 19810701

Applications A common additive for peptide coupling.
E0

Impurity Terazosin EP Impurity M
Applications 1,4-Di-2-furoyl-piperazine (Terazosin EP Impurity M) can be used in biological studies to examine the relationship of structure to parasiticide activity of nitrated derivatives.
References Cavier, R., et al.: Chimica Therapeutica 5, 270 (1970)

Applications 1-Hydroxy-7-azabenzotriazole (cas# 39968-33-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.
References Kronke, J., et al.: Nature 523, 183 (2015); Liu C., et al.: Faming Zhuanli Shenqing CN 105348257 A 20160224 (2016); Rao, R., et al. : PCT Int. Appl. WO 2016024286 A2 20160218 (2016)

Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.
References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)

Impurity Carglumic Acid Impurity B
Applications 3-(2,5-Dioxoimidazolidin-4-yl)propanoic Acid is defined as combinational markers to distinguish hepatocellular carcinoma (HCC) from cirrhosis (CIR).
References Shao, Y., et al.: J. Proteome Res., 14, 906-916 (2015)

Applications 1,2-Bis(2-(4,5-dihydro-1H-imidazol-2-yl)propan-2-yl)diazene Dihydrochloride is used as an initiator in the synthesis of ultra heigh relative molecular mass polyarcrylamide.
References Wang, L., et. al.: Hecheng Shuzhi Ji Suliao, 31, 37 (2014)

Applications 4-Chloro-3-pyridinesulfonamide is a building block that has been used as a reactant for the preparation of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives as inhibitors of four isoforms of zinc enzyme carbonic anhydrase.
References Slawinski, J., et. al.: Eur. J. Med. Chem., 69, 701 (2013)

Applications 3,5-Dimethyl-4-nitropyridine 1-Oxide is an intermediate used to prepare 2-[(2-pyridylmethyl)thio or -sulfinyl]benzimidazoles as antiulcer agents.
References Nohara, A., et al.: U.S., US 4689333 A 19870825. (1987)