Hétérocycles azotés (N)

Applications 4-Amino-3-chloropyridine is a chlorinated heteroarylamine. 4-Amino-3-chloropyridine is used in the preparation of inhibitor of phosphodiesterase type 4 (PDE4) as antiasthmatic agents as well as other pyridine based pharmaceutical agents
References Ashton, M.J. et al.: J. Med. Chem., 37, 1696 (1994);

Stability Light Sensitive
Applications A reagent for the determination of aldehydes and other reactive chemicals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dickinson, R.G. and Jacobsen,N.W. : Chem. Commun., 1719, (1970), Del Nozal, M.J. et al.: J. Liq. Chromatography, 16, 1105 (1993),

Applications 5-Amino-6-methylbenzimidazolone

Applications N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-[5-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]pentyl]-N1-hydroxybutanediamide, is a bifunctional chelator.

Applications 1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole (cas# 212248-62-9) is a useful research chemical.

Applications 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a reagent in the synthesis and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone which is an antibacterial agent. Benzoxazinyl-oxazolidinone had potent activity against Gram-positive pathogens. 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is also an intermediate in the synthesis of Tedizolid (T013750).
References Xin, Q., et al.: J. Med. Chem., 54, 7493 (2011)

Applications 1-(oxan-4-yl)-1H-1,2,3-triazole-4-carboxylic acid (cas# 1487610-80-9) is a useful research chemical.

Applications Succinimide is a reagent that is used in the synthesis of Lumiflavin (L473900), which is a toxic photolysis product of vitamin B2 (R415000).
References Zhao, X. et al.: Chemosphere, 63, 1116 (2006); Litke, S.V. et al.: Khim. Fiz., 10, 48 (1991); Ye, W. et al.: Guang. Yaox. Xueb., 12, 175 (1996);

Applications 4-(Trifluoromethyl)-3-Pyridinecarboxylic Acid is a useful synthetic intermediate. It can be used to prepare pyridine carboxamides as palm site inhibitors of HCV NS5B polymerase. It can also be used to synthesize pyrazolylcarboxanilides as Ca2+ release-activated Ca2+ (CRAC) channel inhibitors.
References Cheng, C., et al.: ACS Med. Chem. Lett., 1, 466 (2010); Yonetoku, Y., et al.: Bioorg. Med. Chem., 16, 9457 (2008)

Applications 1-Piperidin-2-ylacetone Hydrochloride is an intermediate used in the synthesis of 1-Piperidin-2-ylacetone (B449983), which is a useful research chemical.

Applications A nitro substituted piperazine.

Applications 5-Aminomethyl-2-chloropyridine is a reagent that is used in the synthesis of macamides and analogs that have FAAH (fatty acid amide hydrolase) inhibitory activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wu, H., et al.: Bioorg. Med. Chem., 21, 5188 (2013);

Applications N-Succinimidyl 3-Methoxy-4-nitrobenzoate (cas# 2006277-78-5) is a useful research chemical.

Stability Very Hygroscopic
Applications 4-(p-Chloro-α-phenylbenzyl)-1-piperazineethanol is used in the synthesis of antifungal triazole and imidazole derivatives. Impurity of an intermediate in the formation of Cetrizine.
References Rezaei, Z. et al.: Archiv. Pharm., 344, 658 (2011)

Applications 2-Amino-3,5-dibromopyrazine is used in the preparation of conjugated polymers for neurotoxin detection. 2-Amino-3,5-dibromopyrazine is an intermediate in the preparation of rho kinase (ROCK) inhibitors.
References Thomas, J. et al.: Polym. Prepr., 46, 1211 (2005); Henderson, A.J. et al.: Bioorg. Med. Chem. Lett., 20, 1137 (2010);

Applications 2,2,6,6-Tetramethyl-1-hydroxypiperidine is a reactant used in various synthesis and investigations. It was used as a reactant in the study of predicting organic hydrogen atom transfer rate constants using the Marcus cross relation. 2,2,6,6-Tetramethyl-1-hydroxypiperidine was also used as a reactant in the preparation of ammonia from an iron nitrido complex.
References Scepaniak, J., et al.: Angew. Chem. Int. Ed., 48, 3158 (2009); Warren, J., Mayer, J.: Proc. Natl. Acad. Sci. U.S.A., 107, 5282 (2010);

Applications 4-Chloro-3-pyridinesulfonamide is a building block that has been used as a reactant for the preparation of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives as inhibitors of four isoforms of zinc enzyme carbonic anhydrase.
References Slawinski, J., et. al.: Eur. J. Med. Chem., 69, 701 (2013)

Applications 6-Methoxy-N2-methylpyridine-2,3-diamine dihydrochloride (cas# 83732-72-3) is a useful research chemical.

Applications 6,7-Dimethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one is an analogue of Terazosin (T105000), an α-1-adrenergicblocker related to prazosin (P702325).
References Patterson, S.E., et al.: J. Chromatog., 311, 206 (1984), Fort, F.L., et al.: Drug Chem. Toxicol., 7, 435 (1984), Lepor, H., et al.: J. Urol., 148, 1467 (1992),

Applications 2-(1h-1,2,4-Triazol-1-Yl)Acetic Acid (cas# 28711-29-7) is a useful research chemical.

6-Methoxyindole-2-carboxylic acid (6MI) is a potent inhibitor of the enzyme catechol-O-methyltransferase (COMT). This inhibition prevents the conversion of catecholamines, such as dopamine and norepinephrine, to their corresponding methylated products. COMT inhibitors are used clinically to treat Parkinson's disease and other diseases that result from excessive levels of these neurotransmitters. 6MI is also an effective inhibitor of tyrosinase activity in vitro. It has been shown to inhibit the synthesis of melanin by melanocytes and inhibits the production of eumelanin, which is responsible for black or brown skin pigments. The inhibitory potency of 6MI was found to be greater than that for kojic acid, arbutin, and hydroquinone. Optimization studies showed that 6MI was most potent at a concentration of 1 mM and had an IC50 value of 0.3 mM in

Fluoxetine is a selective serotonin reuptake inhibitor that has been used clinically to treat depression. This drug inhibits the reuptake of serotonin, which leads to an increase in the concentration of serotonin in the synaptic cleft and an enhancement of serotonergic neurotransmission. Fluoxetine has been shown to be effective at treating insulin resistance and obesity in clinical studies. The linear calibration curve for fluoxetine was found using confocal microscopy and sequence analysis on human adipose tissue. Fluoxetine treatment increased insulin sensitivity and decreased food intake in rats with metabolic syndrome. Logistic regression was used to establish statistical significance between fluoxetine treatment and weight loss as well as insulin sensitivity. Fluoxetine was also found to increase the mitochondrial membrane potential through regulation of voltage-dependent anion channels, leading to antidepressant activity.

5-Ethylindole-2-carboxylic acid is an organic compound that is a decarboxylation product of indole. It can be obtained by catalytic dehydrogenation of ethyl ester or 5-ethylindole-2-carboxylic acid. It has been shown to inhibit the growth of bacteria and fungi, as well as to have anti-inflammatory properties.

N-(2,6-Dimethylphenyl)-1-piperazineacetamide is a byproduct of solvents and stabilizers. It has been found to be a crystalline solid with a molecular weight of 233.3 g/mol. The crystal structure was determined and found to be composed of two molecules of acetamide that are connected through hydrogen bonds. N-(2,6-Dimethylphenyl)-1-piperazineacetamide is soluble in ethanol and ether, but insoluble in water. This compound interacts with other substances, such as recrystallizing or substituting acetamides.

2-Amino-3-chloropyrazine is an active analogue of pyrazinamide, which is a potent antimycobacterial drug. It has been shown to have bacteriostatic activity against Mycobacterium tuberculosis in vitro and in vivo. 2-Amino-3-chloropyrazine has been shown to inhibit mitochondrial membrane potential, which may be due to its ability to inhibit hepg2 cell growth by decreasing intracellular ATP levels. It also inhibits the synthesis of bacterial DNA and protein, thereby inhibiting bacterial growth. 2-Amino-3-chloropyrazine has also been shown to have antitumor properties against mouse tumor cells. The pharmacokinetic properties of this drug are not well understood yet, but it has been shown that it can be detected in serum after administration

Piperidin-1-yl-acetic acid is a nitrogen-containing organic compound, which is an alkanoic acid. It has a molecular weight of 104.09 and empirical formula C6H11NO2. Piperidin-1-yl-acetic acid is not soluble in cold water, but it dissolves in boiling water to form a white solid. This compound can be used as an enzyme inhibitor or as a pharmacological agent.
Piperidin-1-yl-acetic acid has been shown to inhibit the transcriptional regulation of enzymes that are involved in the production of porphyrins and other heme protein cofactors such as cytochrome c. The compound also inhibits the synthesis of these enzymes by binding to their active sites and inhibiting their function.

5-Bromoindole-3-carboxaldehyde is a water molecule that has been crystallized in the form of an amide. It is a chemical substance with asymmetric synthesis and significant antifungal activity. 5-Bromoindole-3-carboxaldehyde is active against some strains of the fungus Candida albicans and has been shown to inhibit the growth of kidney cells. This molecule also binds to the neurokinin 1 receptor and is used as a probe for fluorescence studies. The efficient method for synthesizing 5-Bromoindole-3-carboxaldehyde includes using silico analysis to confirm the structure on a computer, then performing an asymmetric synthesis with an acid catalyst to produce this compound.

6-Cyanoindole is a synthetic compound that has been shown to have functional properties. It binds to the receptor of the chemokine, which is a type of protein that regulates inflammatory responses. It also inhibits the activity of coagulation factors, which are proteins involved in blood clotting. 6-Cyanoindole has been shown to inhibit cancer cell growth and induce apoptosis (cell death) in a number of cancer cell lines. The fluorescence properties and lifetimes of 6-cyanoindole have been studied extensively. It has also been used as a monomer in copolymerization reactions and is used as an intermediate in the synthesis of 6-bromoindole.