Hétérocycles azotés (N)

<p>Please enquire for more information about 5-Methylpyrimidine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Intermediate in the synthesis of ticagrelor</p>

<p>Please enquire for more information about 5-Fluoro-2-hydrazinopyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Amino-3-methoxypyridine (4AMMP) is a naturally occurring amino acid that can be found in the nuclei of innervated tissues. It is an inhibitor of the enzyme tyrosine hydroxylase and inhibits the synthesis of catecholamines. The concentration of 4AMMP in blood was measured by radioactivity. This agent has been used for studies on the thalamic nucleus and cortex, as well as for measuring catecholamine levels in tissue homogenates.</p>

<p>Gabapentin is a pharmaceutical preparation that is used for the treatment of epilepsy and neuropathic pain. It is also used for postherpetic neuralgia, bipolar disorder, and anxiety disorders. Gabapentin has been shown to bind reversibly to the enzyme adenylate cyclase, which regulates the production of the second messenger cAMP. The binding of gabapentin to this enzyme prevents the conversion of ATP into cAMP and blocks signal transduction. This leads to an increase in intracellular levels of adenine nucleotides (ATP) and suppression of neuronal activity. Gabapentin has high values in kinetic tests because it is a reversible inhibitor with a low Km value. It binds irreversibly to nucleophilic substitutions, which are enzymes that catalyze reactions involving hydrolysis or transfer of one or more hydrogen ions from one molecule to another in a chemical reaction. A fluorine atom on gabapentin's structure may account for its</p>

<p>1-Acetylpiperidine-4-carboxylic acid (ACPC) is a synthetic compound that has been shown to be a potent inhibitor of the neurokinin-1 receptor. ACPC has been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis. It has also been shown to have antipsychotic effects and could be an effective treatment for psychotic disorders. The pharmacophore of ACPC is based on the cyclohexane ring and piperidine moieties, which are thought to provide affinity for the neurokinin-1 receptor.</p>

<p>3-Amino-2-nitropyridine is a heterocyclic compound that is an oxidation product of 2,4,6-trinitrotoluene. 3-Amino-2-nitropyridine is a potent inhibitor of the d4 receptor and has been shown to be active in animal models of cancer and autoimmune diseases. The mechanism of action of this drug is not well understood, but it has been found to inhibit cell proliferation in vitro by binding to nucleophilic sites on the receptor. Nitrobenzoic acid may also contribute to its activity. 3-Amino-2-nitropyridine inhibits inflammatory responses by inhibiting cell proliferation and migration.</p>

<p>Boc-4-carboxymethyl-piperidine is a novel drug that has been shown to have significant correlations with the inhibition of fibrinogen and cellulose. It also has the ability to inhibit arsenite, which may be due to its dithiocarbamate group. Boc-4-carboxymethyl-piperidine has been shown to have significant biological activity in vitro. This molecule has been synthesized and crystallized, and x-ray data have been collected. The molecular structure of this molecule is shown below:</p>

<p>6-Chloro-2-fluoropurine is an analytical reagent with a monoclonal antibody that binds to the nucleic acid of HL-60 cells and can be used for optical analysis. 6-Chloro-2-fluoropurine has been shown to have significant cytotoxicity against HL-60 cells, which may be due to its ability to bind to intracellular targets. 6-Chloro-2-fluoropurine has also been shown to inhibit the growth of HL-60 cells in a fluorescein angiography study and is used as a diagnostic agent for diagnosis of cancer.</p>

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<p>Please enquire for more information about 2-[Chloro(4-chlorophenyl)methyl]-pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 2-(3-phthalimidopropyl)acetoacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

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<p>(R)-tert-Butyl 2-methylpiperazine-1-carboxylate is a versatile building block that can be used for the synthesis of complex compounds. The compound is a reagent, speciality chemical, and useful building block in research. It can be used as a reaction component or scaffold in synthesis. (R)-tert-Butyl 2-methylpiperazine-1-carboxylate has been shown to react with nucleophiles such as amines and alcohols to form stable products. This product has high quality and is useful for chemical reactions involving carbonyl groups.</p>

<p>4-Bromo-2-chloropyridine is a piperazine derivative that has potent inhibitory activity against 5-HT2C receptors. This compound is an amide and has been shown to have the ability to cross-couple with various other compounds, such as fatty acids. It is also used in clinical development for the treatment of obesity, depression, and Parkinson's disease. The purity of 4-bromo-2-chloropyridine can be determined by liquid chromatography methods.</p>

<p>2-Phenylpyridine is a heterocyclic organic compound that has been shown to have x-ray crystal structures. It has redox potentials, nitrogen atoms, and a fatty acid group attached. 2-Phenylpyridine has been shown to have nmr spectra that are characteristic of a transfer reaction mechanism. The steric interactions and the biphenyl groups have been shown to have ancillary effects on the reaction mechanism. 2-Phenylpyridine is also known to coordinate in a geometric shape called octahedral, which is most likely due to hydrogen bonding and photophysical properties. The analytical chemistry of this molecule consists of determining its melting point, boiling point, and density. 2-phenylpyridine</p>

<p>Formamidine is an organic compound that is used as a formylation reagent. It is a byproduct of the chlorination of formaldehyde and dimethylamine. Formamidine is produced by the reaction of chloride with formamide in the presence of dimethylamine, which leads to a high yield. Formamidine reacts with various imidazopyridines to produce a range of substituted imidazopyridines. The type and amount of substituent dictate the selectivity and reactivity of this reaction. The reagents are phosphorous pentachloride, oxalyl chloride, and N-methylformamide.</p>

<p>Lercanidipine is a calcium antagonist that binds to the calcium channels in the membranes of cells, preventing the entry of calcium ions. Lercanidipine is water soluble and can be synthesized using techniques such as elemental analysis and pharmacological techniques. It is also an ionizable drug, which means that its affinity for chloride varies with pH. Lercanidipine has been shown to have strong affinity for erythrocyte membranes and thus has a high selectivity for vascular smooth muscle cells. This drug also has a low toxicity profile and does not affect tissues other than vascular smooth muscle cells.</p>

<p>2,2', 2'' -Terpyridine is a chelate ligand that is used in wastewater treatment. It can be synthesized by reacting 2-aminopyridine with ethylene diamine and 2,4-dichloro-1,3-dithiolane. The x-ray crystal structures of the ligand show that it has a coordination geometry of octahedral and its reaction mechanism is an oxidation. The chelate ligand binds to the metal ion in the same way as other ligands and stabilizes it by forming hydrogen bonds. This compound has significant cytotoxicity against carcinoma cell lines and also inhibits the mitochondrial membrane potential (MMP). 2,2', 2'' -Terpyridine is classified as group p2 due to its redox potentials and cytotoxicity.</p>

<p>2-Bromo-5-hydroxypyridine is an aromatic compound that is used in the synthesis of a variety of pharmaceuticals and other organic compounds. It can be synthesized by the Suzuki coupling reaction from 2-bromobenzaldehyde and 5-aminopyridine. 2-Bromo-5-hydroxypyridine has been shown to be a hepatotoxin in humans, with possible carcinogenic activity. It also has cholinergic properties, as well as being able to cause fluorescence when exposed to halogens. The carbon next to the hydroxyl group is a stereocenter, so there are two different configurations for this molecule. The configuration shown above (R) is the more stable form of this molecule due to its electron withdrawing power on the neighboring oxygen atom.</p>

<p>Cucurbit[7]uril is a chemical compound that can be used as a fluorescent probe for protein target. It has been shown to produce significant cytotoxicity against cancer cell lines in vitro. Cucurbit[7]uril also exhibits hydrophobic effects, which bind to the cell nuclei of cancer cells and inhibits DNA replication. The photophysical properties of cucurbit[7]uril are stable under physiological conditions and it can be used in vivo as a styryl dye. This chemical compound is also able to form stable complexes with carbonyl oxygens, making it an interesting candidate for anti-cancer drug development.</p>

<p>Please enquire for more information about N-[5-(4-Bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N′-propylsulfamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

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<p>2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions.<br>2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,</p>

<p>3-Iodo-1H-pyrrolo[2,3-b]pyridine (3IOP) is a molecule that has been shown to be cytotoxic against human ovarian carcinoma cells. It induces significant cytotoxicity in cancer cell lines and inhibits the proliferation of lung fibroblasts. 3IOP has been shown to activate cellular signaling pathways and cause multinuclear DNA damage.</p>

<p>Please enquire for more information about Domperidone N-oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,3-Pyridinedicarboxylic acid dimethylester (PDDE) is a methylated derivative of 3-nitrophthalic anhydride. It has been shown to be a stereoselective receptor blocker that binds to the glutamate site of the N-methyl-D-aspartate receptor. PDDE has also been shown to have high affinity for the cerebral cortex and is able to penetrate the blood brain barrier. PDDE blocks the NMDA receptor by binding to it and preventing ion flow, which leads to inhibition of neurotransmitter release. This drug is used as an injectable methyl derivative with a molecule weight of 217. The ionization detector can detect PDDE in tetrahydrofuran at concentrations of 1,000 ng/mL or less.</p>

<p>2,4-Dichloro-3-nitropyridine is a halogenated pyridinium salt that has been shown to inhibit the influenza virus in vitro. This compound is also reactive with nucleophilic groups such as amines, alcohols, and thiols. 2,4-Dichloro-3-nitropyridine has been used for the synthesis of quinoline derivatives that have potential applications in autoimmune diseases or cancer. 2,4-Dichloro-3-nitropyridine has also been found to be an inhibitor of tumor necrosis factor alpha (TNFα) production by LPS stimulated human monocytes.</p>

<p>5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine is a drug that inhibits serotonin reuptake. It has been used to treat a number of neurological disorders including depression and Parkinson's disease. This drug is a nonselective inhibitor of serotonin uptake and also inhibits the reuptake of norepinephrine. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine has been shown to enhance cardiac contractility without altering heart rate or rhythm in anesthetized dogs with experimental coronary artery occlusion. The drug also reversibly inhibits epileptic seizures in rats when administered intravenously at a dose of 1 mg/kg. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine has been shown to have insulin resistance effects in mice with diabetes mellitus and may be useful as a pharmaceutical</p>

<p>3-Bromoimidazo[1,2-b]pyridazine (BIPM) is an analog of etoposide and has been shown to be a potent inhibitor of tyrosine kinases. BIPM selectively inhibits the activity of multikinase enzymes such as c-kit, PDGFRβ, and VEGFR2. In addition, BIPM has been shown to inhibit the proliferation of cancer cells by inducing apoptosis and cell cycle arrest in mcf-7 cells. This drug is not toxic to normal cells and shows a favorable safety profile when tested on animals.</p>

<p>3-Chloropyridazine-4-carbonitrile is an acridone that has been shown to be an effective antibacterial agent. It was synthesized by the intramolecular Diels-Alder reaction of pyridine and 1,3-butadiene, followed by a sequence of reactions involving thioxanthones. 3-Chloropyridazine-4-carbonitrile binds to the bacterial enzyme 50S ribosomal subunit by competitive inhibition and prevents the formation of an antibiotic inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. 3-Chloropyridazine-4-carbonitrile also has shown activity against methicillin resistant Staphylococcus aureus strains.</p>

<p>3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one is a synthetic compound that has been shown to have potent antiplatelet activity. It was developed as a new drug for the prevention of thrombosis and embolism, and was recently approved by the FDA in 2010. The molecular weight of this compound is 459.3 g/mol with an impurity level of 1.2%. 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one is used in the pulping process for paper production.</p>

<p>2-Amino-6-chloropurine is a nucleophilic substituent that is used in the synthesis of 2-amino-6-chloropurine. It reacts with hydroxyl groups to form a palladium-catalyzed coupling reaction solution, which is then treated with hydrochloric acid and trifluoroacetic acid. The product is purified by crystallization and recrystallization. This compound has potent antitumor activity against carcinoma cell lines, but it has not been shown to have any effect against Mycobacterium tuberculosis.</p>

<p>3-Piperidin-1-ylpropan-1-ol is a substance that is structurally related to biperiden and has affinity for the H3 receptor. It has been shown to have a high affinity for the H3 receptor, which is found in high concentration in the rat brain. 3-Piperidin-1-ylpropan-1-ol has been shown to have antagonistic activity against neuropathic pain in rats, by inhibiting the release of norepinephrine from nerve endings. This substance also has antihistaminic properties, which may be due to its ability to inhibit histamine release. 3-Piperidin-1-ylpropan-1-ol is an enantiomer of piperidine, with a slightly higher affinity for the H3 receptor than its mirror image. The racemic mixture isomeric form (i.e., both enantiomers) inhibits the H3 receptor with an equal potency,</p>

<p>Please enquire for more information about 2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

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<p>Please enquire for more information about Chlorpheniramine N-oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine is a novel analog of benzyl alcohols that binds to the delta opioid receptor. The compound was found to be an agonist in vitro and in vivo. It showed no affinity for other opioid receptors or for the benzodiazepine receptor. (-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine was found to have high affinity for the human cloned delta opioid receptor with a Ki value of 0.6 nM. This compound is also a potent alkylate inhibitor with an IC50 of 6 microM against ethoxy radical formation and an IC50 of 25 microM against lipid peroxidation induced by H2O2.</p>

<p>Please enquire for more information about N-Nitroso ramipril including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Orotic acid hydrate is a synthetic compound that is designed to be a growth regulator. Orotic acid hydrate is synthesized by reacting the orotate with pyridoxine hydrochloride, followed by crystallizing the product. Hydrogen bonds form between the water molecules and fatty acids in the crystals of OA hydrate. These hydrogen bonds stabilize the crystal structure and allow for its use as a growth regulator. The stability of this molecule can also be attributed to its ability to form hydrogen bonds with other molecules such as α-tocopherol, calcium carbonate, and synthetic cannabinoids. Orotic acid hydrate has been shown to have an effect on cancer cells because it reacts with daunorubicin in solution and inhibits DNA synthesis, inhibiting cell growth.</p>

<p>Please enquire for more information about 5-Bromothieno[2,3-b]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Zinc pyrithione is a chemical compound that can be used as an antifungal agent. It has been shown to have genotoxic activity in vitro and in vivo. Zinc pyrithione binds to the surface of the fungal cell wall and inhibits the synthesis of ergosterol, a component of the fungal cell membrane. This binding prevents the formation of an ergosterol-zinc complex with cytochrome P450 enzymes, which are required for sterol biosynthesis, leading to inhibition of energy metabolism. The model system for zinc pyrithione is a mixture of 1-hydroxypyridine-2-thione (1HP) and zinc ions in water. Some studies have shown that zinc pyrithione can cause long-term toxicity, including glycol ether toxicity, when applied topically on hair or skin. Acute toxicities may include skin irritation or contact dermatitis from shampoos containing this substance.</p>

<p>Pyridine-2-aldoxime is a chemical compound that is used as a pesticide. It is an inhibitor of acetylcholinesterase, and it can be toxic at low doses. Pyridine-2-aldoxime binds to the active site of acetylcholinesterase and prevents the breakdown of acetylcholine by this enzyme, leading to paralysis of the respiratory muscles. Pyridine-2-aldoxime has been shown to be effective against chronic oral exposure to sarin gas, with lethal dose (LD) values ranging from 0.5–1 mg/kg in rats.</p>

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