Hétérocycles azotés (N)

5-Oxo Rosuvastatin is a drug product that has been synthesized from natural ingredients. It is an analytical standard for the impurity, 5-oxo-rosuvastatin, which is a potential impurity in the API, rosuvastatin. This drug product has been custom synthesized in order to provide an Impurity Standard for HPLC. This drug product is also used as a Synthetic Reference Standard for Drug Development and Research and Development.

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7-Chlorothieno[3,2-B]pyridine is a nucleophilic compound that is used as an inhibitor of the tyrosine kinase enzyme. It binds to the ATP binding site and blocks the enzymatic activity of the enzyme, preventing cell proliferation. 7-Chlorothieno[3,2-B]pyridine has been shown to inhibit growth in tumour cell lines and has been shown to be effective against tyrosine kinase receptor positive cancer cells. This drug also shows a cytotoxic activity against tumour cells in vivo, which may be due to its ability to inhibit factor receptor and receptor tyrosine.

2,3-Difluoro pyridine is an organic compound with the chemical formula C6H3F2N. It is a colorless liquid that has a strong odor and a boiling point of 147°C. 2,3-Difluoro pyridine has antibacterial properties and can be used to treat bacterial infections by inhibiting the synthesis of proteins in bacterial cells. This inhibition prevents the formation of new cell walls, which leads to cell death. 2,3-Difluoro pyridine is also used as an intermediate in organic chemistry reactions involving hydrogen fluoride. The transport properties of this compound are low due to its high melting point and low solubility in water. There are three different polymorphs for 2,3-difluoropyridine: form II, form III and form IV, with form II being the most common. Form II has a trigonal planar molecular geometry, whereas forms III and IV have tetragonal

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2-Chloro-4-pyrimidinecarbonitrile is a synthetic compound that belongs to the group of phenylpyrimidines. It inhibits the tyrosine kinase activity and cytokine production in cells. 2-Chloro-4-pyrimidinecarbonitrile is used as an immunomodulatory agent in the treatment of cancer, autoimmune disorders and other immune dysfunctions. This drug also has anti-inflammatory properties and can be used for the treatment of inflammatory bowel diseases, such as ulcerative colitis or Crohn's disease. 2CPCN is metabolized by deamination and demethylation, which leads to the formation of nitrite ion, a reactive nitrogen species that can cause DNA damage.

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2-Cyano-5-fluoropyridine is a potential antitubercular agent that has shown penetrability in the central nervous system and activity against Mycobacterium tuberculosis. It is orally active at low doses, and has been shown to be an effective inhibitor of mycobacterial growth and lipid synthesis. In addition, this compound also has antimycobacterial activity against M. avium complex and M. ulcerans, and is a potent inhibitor of β-amyloid aggregation.

N-Benzoylpiperidone is a synthetic piperidine derivative that is used in the synthesis of other organic compounds. It can be synthesized by reacting phenylacetaldehyde with chloroacetonitrile and hydroxybenzene. It can also be synthesized by reacting bromoacetonitrile with hydroxybenzene in the presence of sodium hydroxide. The compound has two stereoisomers, which are determined by the configuration at the nitrogen atom. The N-benzoyl group on one stereoisomer binds to the intramolecular hydrogen molecule, which signifies its structural analysis. These two isomers are distinguished by their hydroxy group, amide and alkylation properties. They react differently with rat liver microsomes due to different substrate concentration.

2-Amino-1,3,5-triazine is a hydrogen bond donor that has been shown to have growth inhibiting effects. It reduces the viscosity of aqueous solutions and is used as an enantiopure for amines. 2-Amino-1,3,5-triazine can be used in reactions with metal surfaces to produce surface coatings or used as a bifunctional crosslinking agent for polymer materials. 2-Amino-1,3,5-triazine has been shown to have degenerative disease inhibitory activity and inflammatory disease inhibitory activity. It also inhibits the production of inflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin 6 (IL6).

2,6-Dichloro-5-nitropyrimidin-4-amine is a chlorinating agent that reacts with aliphatic and aromatic amines to form substituted pyrimidines. The substitution pattern of the product depends on the regioselectivity of the reaction. 2,6-Dichloro-5-nitropyrimidin-4-amine is one of the few chlorinating agents that react with propylamine. Substitution at position 2 of the purine ring has been found to be more selective than substitution at position 6. The 2,6-dichloropyrimidine can also be used as a nitro group source in chemical synthesis or as an intermediate in production of other compounds.

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2-Amino-6-hydroxy-8-mercaptopurine is an antimicrobial agent that inhibits the growth of bacteria by binding to their ribosomes. It has been shown to have a cytotoxic effect in vivo on cancer cells and intestinal parasites, as well as a protective effect against infectious diseases. 2-Amino-6-hydroxy-8-mercaptopurine has also been shown to inhibit the synthesis of proteins in vitro, which may be due to its ability to bind to the ribosomal subunit and inhibit protein synthesis. 2-Amino-6-hydroxy-8-mercaptopurine inhibits bacterial growth by binding to DNA dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or gluc

Pyridine-3-sulfonamide is a diazonium salt that has shown anticancer activity against human colon HCT116 cells. It inhibits the proliferation of leukemia cells by inhibiting the uptake of glucose, and it also has inhibitory properties on l1210 murine leukemia cells. Pyridine-3-sulfonamide binds to metal surfaces and accumulates in the cytoplasm of cancer cells, which may be due to its structural formula consisting of a pyridine group and a sulfonamide group. This compound can be used as an anticancer drug for cancer treatment.

3-Vinylpyridine, also known as vinylpyridine, is a colorless, crystalline solid that forms hydroxide solutions. It has been shown to have antifungal activity in the presence of fatty acids and can be used for the treatment of urinary tract infections caused by Candida albicans. The chemical ionization technique was used to analyze 3-vinylpyridine in urine samples from nonsmokers and smokers. Long-term exposure to 3-vinylpyridine may lead to surface-enhanced Raman spectroscopy signals on the surface of metal oxides due to alkoxy radical formation. The crystallization process of 3-vinylpyridine can take place at a temperature range between 135°C and 150°C with an addition of polyethylene glycol or sulfuric acid. Reaction intermediates are formed during this process which are important for the formation of 3-vinylpyridinium ions.

4-Phenyl-4-carbethoxy piperidineHCl is a germanium compound that can be used as a diagnostic agent to detect the presence of magnesium in the blood. It has been shown to bind to acidic and basic sites on the brain, regulating the functions of these regions. The drug has also been shown to have analgesic properties, as it activates opioid receptors in the brain. 4-Phenyl-4-carbethoxy piperidineHCl binds with high affinity to meperidine and naloxone, which are opioid receptor agonists. It is also able to bind to pentazocine, an opioid receptor antagonist. This drug is not active against molybdenum or thebaine.

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Bis(pyridine)iodonium tetrafluoroborate is a reagent that can be used to iodinate organic compounds. It is prepared by the reaction of pyridine with iodine and bromine in tetrafluoroboric acid. Bis(pyridine)iodonium tetrafluoroborate is an active compound that can be used for amino acid analysis, optical properties, and functional groups. This compound also can be used for magnetic resonance analysis, palladium-catalyzed coupling, and synthetic reactions. Bis(pyridine)iodonium tetrafluoroborate has been found to have radiation transport properties and a strong reactivity towards acids.

a-Butylpiperonyl alcohol is a chiral molecule that is used in the synthesis of esters. It can be produced by microbial fermentation and low-temperature chemical reactions. This compound has been shown to inhibit the growth of Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae. The biosynthetic pathway for a-butylpiperonyl alcohol is not yet well understood, but it has been hypothesized that this compound is synthesized from an intermediate, acetic acid. The enzyme responsible for this conversion is unknown, but it may be catalysed by an acylase or acetate kinase. A study on the genome sequence of Coelicolor revealed that this organism produces a-butylpiperonyl alcohol from the intermediate 3-hydroxypropanoic acid.

2-(Tributylstannyl)pyrimidine is a synthetic heterocycle that has antibacterial activity. It is a guanine analog that binds to the ribonucleic acid (RNA) of bacterial cells and inhibits protein synthesis by attacking the 4-chloropyrimidine moiety of nucleoside monophosphates. 2-(Tributylstannyl) pyrimidine also has antiviral properties and acts as an inhibitor of vitamin B1, which is required for the synthesis of DNA. This drug can be used in the treatment of sulfamethoxazole-resistant infections caused by bacteria such as Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa.
2-(Tributylstannyl)pyrimidine is effective at inhibiting the growth of bacteria due to its ability to form an ion pair with chloride ions. This property makes it highly reactive for transmetall

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Kinetin is a chemical compound that is used in research as a reagent, useful scaffold, and an intermediate. It has been shown to be an effective building block for the synthesis of complex compounds. Kinetin is also a versatile building block that can be used to synthesize many different types of compounds. Kinetin has a CAS number 525-79-1 and is classified as a speciality chemical.

Pyridine-sulfur trioxide complex is a sodium salt of sulfuric acid and pyridine. It is an intramolecular hydrogen acceptor, which means that it can act as a hydrogen donor to other molecules. Pyridine-sulfur trioxide complex has been shown to be effective against HIV infection in vitro. The biological properties of this drug are due to its ability to inhibit the proliferation of cells. Pyridine-sulfur trioxide complex also has antiproliferation activity against a variety of cancers, including prostate, breast, lung, ovarian, and pancreatic cancers. Pyridine-sulfur trioxide complex inhibits fatty acid synthase enzymes and is used as an analytical method for measuring cholesterol levels in the blood.

1-(2-Chloroethyl)piperidine hydrochloride is a chemical compound that has photochemical properties. It is used as an amine and in the synthesis of other chemicals. The crystal structure of 1-(2-Chloroethyl)piperidine hydrochloride has been determined by X-ray crystallography. It also has antibacterial activity and inhibits the growth of bacteria by binding to single-stranded DNA, which prevents DNA replication. 1-(2-Chloroethyl)piperidine hydrochloride binds to DNA with tetradentate coordination, forming a stable complex which does not allow the DNA polymerase to bind to the single strand. 1-(2-Chloroethyl)piperidine hydrochloride can be detected using mass spectrometry and nuclear magnetic resonance spectra.

Pyrimidin-4-ylmethyl)amine dihydrochloride is a drug that belongs to the class of drugs known as kinase inhibitors. Pyrimidin-4-ylmethyl)amine dihydrochloride inhibits the kinase activity of Jak3, which is involved in regulating inflammation and immune response. This inhibitor has been shown to be effective against chronic inflammatory diseases such as asthma, psoriasis, and rheumatoid arthritis. Pyrimidin-4-ylmethyl)amine dihydrochloride has an affinity for ATP binding sites and can be used to regulate kinase activity by competing with ATP for these binding sites.

Pyridine-3-sulfonic acid is a reactive molecule that can exist in two forms. It reacts with iron oxides to form pyridine-3-sulfonic acid amide and reacts with picolinic acid to form pyridine-3-sulfonic acid phosphoric acid complex. Pyridine 3 sulfonic acid is an intermediate in the synthesis of picolinic acid and is involved in the genetic mechanisms of bacteria. It has been shown to be effective at concentrations of 10 mM or higher when used in tissue culture experiments. The optimum concentration for the reaction varies depending on the reactant and its environment, which is why experimentation should be conducted before using it as a reagent.

1,3,5-Triacryloylhexahydro-1,3,5-triazine (TTH) is a particle that absorbs UV light. It is a reactive chemical with a high thermal stability and low reactivity to air. TTH has been used as a cross-linker in polymer films and as a microsphere filler. The absorption of UV light by TTH may be due to the presence of hydroxyl groups or nitrogen atoms. The nmr spectra show that TTH contains trimethylolpropane groups.

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The drug, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride (CGP 46660), is a competitive antagonist at the human histamine H3 receptor. It has been shown to bind to the histamine H3 receptor in the range of 0.001 to 1 μM and is selective for this receptor over other receptors. CGP 46660 is an optical sensor that can be used in titration calorimetry experiments to measure changes in heat production when it binds to histamine H3 receptors. The drug also has been shown to inhibit guanine nucleotide-binding protein (G protein) signaling pathways and brain functions such as memory formation, learning, and attention span. These effects were demonstrated in humans by measuring EEG activity. The optimum concentration of CGP 46660 for these effects was found to be between 0.01 and 10 μM.

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3H-Spiro[2-benzofuran-1,4'-piperidine] is a ligand with affinity for melanocortin receptors. It has been shown to bind with low affinity to the melanocortin receptor and act as an agonist. 3H-Spiro[2-benzofuran-1,4'-piperidine] has high affinity for benzene, which may be due to its ring system. This ligand also has a penetrable structure that allows it to bind to piperidine binding sites.

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Pyridine-2,5-diol is a bacterial metabolite that is the product of the enzyme pyridoxal 5'-phosphate oxidase. This enzyme has been shown to be involved in microbial metabolism and enzymatic reactions, such as the conversion of picolinic acid to pyridine-2,5-diol. Pyridine-2,5-diol has been found to be expressed in wild type strains but not in mutant strains. The gene product for this enzyme has also been identified as maleate dehydrogenase.

3-Chloro-4-nitropyridine 1-oxide is the condensation product of 2-chloro-3-nitropyridine and nitric acid. 3-Chloro-4-nitropyridine 1-oxide has an isomeric nature and can be purified by recrystallization from water. The compound has a molecular weight of 286.1 g/mol and a monoclinic crystal structure. It has two n-oxides, which are isomers of each other, with nmr spectra that differ by the shift in the chemical shifts of the protons on the aromatic ring. 3-Chloro-4-nitropyridine 1-oxide condenses with lanthanides to form lanthanide complexes, such as Eu(III)(3,5'-ClO 4 ) 2 . This compound is also used in the synthesis of phenoxathiine derivatives that have antihypertensive activity.

3-Amino-4-methoxypyridine is a molecule that has been shown to have anesthetic activity. It has been shown to inhibit the uptake of glycogen by glioblastoma cells and decrease the rate of glycogen synthesis in these cells. 3-Amino-4-methoxypyridine also inhibits the production of ATP in cardiac muscle cells, which may be due to its ability to inhibit glycogen synthase kinase-3 (GSK3) and glycogen synthase. This drug also inhibits cancer cell growth by inhibiting protein synthesis, as well as inflammatory disease progression by inhibiting NFκB activation and cytokine production. 3-Amino-4-methoxypyridine can be synthesized from aminopyridines such as isonicotinic acid or nicotinic acid, which are oxidized with hydrogen peroxide and sodium nitrite in the presence of a base catalyst.

1-[(4-Chlorophenyl)phenylmethyl]piperazine is an analytical reagent that is used in the determination of meclozine, a drug used for the treatment of nausea and vomiting. 1-[(4-Chlorophenyl)phenylmethyl]piperazine is a nucleophile, which means that it can donate electrons to other molecules. It can be used as a catalyst to increase the rate of chemical reactions. 1-[(4-Chlorophenyl)phenylmethyl]piperazine may also be used in wastewater treatment because it has been shown to have phospholipidosis inhibiting properties. The levorotatory form (1R-enantiomer) of this compound has been shown to inhibit protein synthesis in vitro and is an amine oxidase inhibitor that binds to proteins with nitrogen atoms. This nucleophilic compound may also be converted into an n-oxide or dinucleotide phosphate by hydrochloric acid and

4-Hydroxypyridine-3-sulfonic acid is the anion of 4-hydroxypyridine with sulfate. It has a pK a of 1.5 and is soluble in water, ethanol, and methanol. 4-Hydroxypyridine-3-sulfonic acid can be used as a crystallographic data collection reagent. The anion can act as an acceptor for radiation and can also be used to generate hydrogen sulfate. Hydrogen sulfate is generated by the reaction of sulfuric acid with potassium hydroxide or sodium hydroxide. Hydrogen sulfate reacts with elemental sulfur to produce hydrogen sulfide. This compound has been shown to have properties that make it useful in analytical chemistry, such as its ability to form hydrogen bonds and act as an anion. The structure of 4-hydroxypyridine-3-sulfonic acid is shown below: 4 H O 2 S

4-Pyrimidinecarboxaldehyde is an organic compound that is used in the synthesis of pyrazoles. It can be prepared by the reaction of ethylenediamine with molybdenum trioxide in ethanol, followed by hydrolysis of the amine. 4-Pyrimidinecarboxaldehyde can also be obtained from methylpyrazine by oxidation to methylpyrazone and subsequent reaction with magnesium oxide. The nature of 4-pyrimidinecarboxaldehyde’s molecular target is not yet known, but it has been shown to have antineoplastic properties.