Composés aliphatiques et dérivés

1-Hexen-3-one is a carbonyl compound that has been shown to act as an estrogen receptor modulator. It has been isolated from the reaction product of hexene and formaldehyde, in which the intramolecular hydrogen is transferred to the carbon atom adjacent to the carbonyl group. 1-Hexen-3-one has been shown to induce muscle cell proliferation in vitro and inhibit liver microsomal protein synthesis in vivo. The 1-hexen-3-one can be prepared by reacting hexene with formaldehyde. The yield of this reaction is about 80%.
2 HCHO + C6H12 → C6H14O + 2 HCOOH

2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.