Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Formylfuran-3-carboxylic acid is a furan derivative with an oxidation product that has been shown to be useful as a peroxide scavenger. It is synthesized by the reaction of 2-formylphenol and formaldehyde in the presence of copper salts. The molecular modelling studies revealed that this compound consists of a five membered ring with an oxygen atom at its centre, which is flanked by two carbon atoms at each side. The carboxylic acid group (-COOH) is on one end and the hydroxymethyl group (-CHOH) on the other end. The molecule also has a carbonyl group (-C=O) and a methylene bridge (-CH2-) between the two carbon atoms. This compound has been found to have efficient antioxidant properties when it reacts with reactive oxygen species (ROS). It was also found to have antioxidative activities when it reacts with ROS produced by galacturonic acid and fur</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2-Benzoyl-4-methoxyphenol is a surfactant that is sustainable and biodegradable. It is used in the production of micelles to form detergents, which are important for the environment. The binding constants of this chemical with 2-hydroxybenzophenone and benzyl have been determined at different temperatures. 2-Benzoyl-4-methoxyphenol has been shown to be an effective transient probe for mechanistic investigations in organic chemistry. This compound can be prepared by reacting benzaldehyde with methoxyacetophenone in acetonitrile. Irradiation can break down the benzene ring, producing phenoxy (2,6-dioxo)cyclohexane or 2-(2,6-dioxo)cyclohexanone. 2-Benzoyl-4-methoxyphenol also has hydrophobic properties and can be used as a surf</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>8-Hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione is a natural product that has been found to have anticancer activity. It induces apoptosis in human cancer cells and inhibits the growth of bacteria by binding to the 50S ribosomal subunit. 8HMN has also been shown to inhibit the proliferation of cervical cancer cells in vitro. The active form of this compound is acetate extract and it has been shown to have strong anti-inflammatory properties by inhibiting prostaglandin synthesis in neutrophils. 8HMN binds to mitochondrial membrane protein complexes, leading to mitochondrial fission and inhibition of ATP production.</p>

<p>3-Methyl-2,3-dihydro-1,3-benzothiazol-2-imine is an imine nitrogen that is a ligand for transition metals. It is used in the synthesis of 1,3-benzothiazoles and has been shown to have anti-malarial activity. 3-Methyl-2,3-dihydro-1,3-benzothiazol-2-imine interacts with aldehydes to form ring opening products. This compound also has been shown to be a ligand for palladium and platinum metals. The compound has been functionalized with thiol groups and can be used as a reagent in organic synthesis.</p>

<p>7-Methylbenzo[d]thiazol-2-amine is an antimicrobial agent that has been shown to have both antibacterial and antifungal properties. It has a broad spectrum of activity against Gram-positive and Gram-negative bacteria, as well as fungi. 7-Methylbenzo[d]thiazol-2-amine also inhibits the growth of yeast cells by interfering with their ability to produce proteins necessary for cell division. This drug can be synthesized using a number of different techniques, including the reaction between phenyl mercaptan and dimethyl acetylenedicarboxylate in the presence of aluminium chloride or phosphorus pentachloride. The yield is typically low (5%).</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>7-Diethylamino-4-hydroxy-chromen-2-one is a fluorescent chemical compound that belongs to the family of atypical fluorophores. It has a number of photophysical properties, including fluorescence and regression, which are characteristic of amines. 7-Diethylamino-4-hydroxy-chromen-2-one can be synthesized from diazonium salt and 4-hydroxycoumarin. This chemical compound has been used as a fluorescent probe for nucleophilic reactions in various types of organic molecules. The nature of this fluorophore is unknown, but it may be due to its ability to shift the wavelength of fluorescence by up to 400 nm.</p>

<p>5-Methyl-3-oxohexanenitrile is a dialkylamino compound that has been used as a reagent in organic chemistry. It is tautomeric and can exist as both an amide and an isoxazole. The pyridine ring of 5-methyl-3-oxohexanenitrile can be either substituted with a carbamate, nitro, or alkenyl group, depending on the substitution pattern. 5-Methyl-3-oxohexanenitrile reacts with dinitrophenyl to form an N–N bond, which is then cleaved by amines in order to generate the corresponding carbamate or amide. 5-Methyl-3-oxohexanenitrile also reacts with copper to form the corresponding nitro or alkenyl group.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

1,2-Dibromo-4-(bromomethyl)benzene is a brominated organic compound that has been shown to act as a potent agonist for the peroxisome proliferator-activated receptor delta (PPARδ). It has been shown to have structural and biological effects on PPARδ. This compound has been used as a template in the synthesis of many other compounds. 1,2-Dibromo-4-(bromomethyl)benzene is non-selective and bioavailable, which means it can be taken orally or applied topically.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-(5-Nitro-thiazol-2-yl)-benzamide is a noncompetitive inhibitor of the enzyme succinate dehydrogenase and is used as an molluscicide. It binds to the active site of the enzyme, which is located in the mitochondrial membrane, and prevents electron transfer from succinate to ubiquinone. This leads to a decrease in production of ATP, which is needed for cell growth and division. N-(5-Nitro-thiazol-2-yl)-benzamide has been shown to inhibit inflammation by inhibiting prostaglandin synthesis in mice. The drug also inhibits neutrophil infiltration into inflamed areas, which may be due to its effect on 5HT2A receptors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Cyanophenyl chloroformate is a macrocyclic compound that has been shown to have a potential use as an almqvist reagent. Almqvist reagents are nucleophilic compounds that can be used in organic synthesis as carbonylating agents, which are used to form esters and amides. 4-Cyanophenyl chloroformate is a chiral compound with the ability to form macrocycles, which are biomimetic structures. The conformational stepwise reaction of the macrocycle formation enables it to mimic natural processes.</p>

<p>Ethyl 2-(2-aminophenyl)acetate is a cytotoxic agent that binds to DNA and inhibits the synthesis of RNA and protein. It has been shown to inhibit the growth of murine leukemia cells in culture at concentrations between 0.3 and 3 mM, which are dependent on the concentration of benzyl substituents. Ethyl 2-(2-aminophenyl)acetate also exhibits dose-dependent cytotoxic activity against murine leukemia cells. The cytotoxic effects of this compound have been studied in vivo and in vitro using murine leukemia cells (WEHI-3).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(3-Bromopropyl)-4-chlorobenzene is an expedited source of chlorine that is used in the oxidation of aromatic compounds. The chlorination of 1-(3-bromopropyl)-4-chlorobenzene occurs with a yield of about 98% and has high selectivity for the chlorination product. In a photoredox process, this compound can be used as an oxidant to produce an intermediate that can then be used in the oxidative chlorination reactions. This compound has been shown to have bioactivity and is used as a science catalyst.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-[(Cyclopropylcarbonyl)amino]acetic acid is a carboxylic acid that is used as an oral drug for the treatment of cardiac and renal diseases. It has been shown to be effective in the treatment of angiotensin-dependent hypertension and congestive heart failure. The therapeutic effects may be due to its ability to inhibit angiotensin-converting enzyme (ACE) and block the conversion of angiotensin I to angiotensin II, which causes vasoconstriction and increased blood pressure. 2-[(Cyclopropylcarbonyl)amino]acetic acid also inhibits phosphodiesterase, which may lead to improved cardiac function.</p>

<p>2-Methyl-5-oxopyrrolidine-2-carboxylic acid (2MOP) is a levulinic acid derivative with a carboxylic acid group on the side chain. It can be synthesized from levulinic acid, which is produced from the hydrolysis of cellulose. 2MOP is used as a plasticizer and an intermediate in the synthesis of esters such as methyl acetate and ethyl acetate. 2MOP has been found to have good compatibility with polyvinyl chloride, polystyrene, and polyolefins. This compound has been used to produce plastics that are flexible, tough, and resistant to heat degradation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Acetamidobenzenesulfonamido)-3-methylbutanoic acid is a disordered molecule that has an isopropanol group at the 4th carbon. The benzene ring and methyl groups are in the 2nd and 3rd positions, respectively. The orientation of the isopropyl group determines how the molecule folds. This molecule has hydrogen bonds between its N-H and C=O groups, as well as intramolecular hydrogen bonds along with coplanar dihedral angles.<br>2-(4-Acetamidobenzenesulfonamido)-3-methylbutanoic acid is used for research purposes to study benzene rings, methyl groups, and acetamide orientations.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one is a synthetic drug that binds to the opioid receptor and is used as an analgesic. It has been shown to have a strong affinity for opioid receptors in the central nervous system and intestine. 2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one has been found to have an uptake of 40% in the brain and intestine. This drug also has a high affinity for opioid receptors in the brain and intestinal tissue and acts as a full agonist on these sites. 2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one also has been found to be effective in treating Alzheimer's disease. This drug can be administered orally or intravenously.

<p>(2S)-2-Amino-N,4-dimethylpentanamide is an amide that is a metabolite of the amino acid l-tert-leucine. This drug has been shown to have bioactive properties and may be used in pharmaceutical preparations for the treatment of degenerative diseases. (2S)-2-Amino-N,4-dimethylpentanamide binds to cannabinoid receptors, which are found on the surface of cells. It also inhibits matrix metalloproteinase activity, leading to increased bone resorption and ulceration. The stereoisomers of this compound have different activities: 2R-(+)-(2S)-2-amino-N,4-dimethylpentanamide inhibits the production of inflammatory proteins and is used as a pharmaceutical preparation for the treatment of ulcers; 2S-(+)-(2S)-2-amino-N,4-dimethylpentanamide has</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(S)-1-phenyl-2-propyn-1-ol is a bicyclic compound that is used in the metathesis reaction. This chemical can undergo a metathesis reaction, where two different types of bonds are broken and two new ones are formed. (S)-1-Phenyl-2-propyn-1-ol can be used for the synthesis of polymers, pharmaceuticals, and agrochemicals.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(2-Formylphenoxy)propanoic acid is a carboxylic acid that is used in the synthesis of pharmaceuticals. The carboxylic acid group of 3-(2-Formylphenoxy)propanoic acid reacts with amines to form amides. It can also be reacted with alcohols to form esters. The propanoic acid group in this compound can undergo reactions that generate carboxylic acids, alcohols, and hydrocarbons. 3-(2-Formylphenoxy)propanoic acid has two carboxylic acid groups, one on each end of the molecule. These groups are positioned so they react with other molecules by donating their electrons to create new bonds. This conformation is called a dimer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

3-Ethoxy-4-nitrophenol is a nitro compound that is used in the synthesis of dibenzofurans, polychlorinated biphenyls, and other organic compounds. It can be used to generate nitro groups in organic synthesis and has been shown to have high yields. 3-Ethoxy-4-nitrophenol is metabolized by the liver with a half life of approximately 10 hours and is excreted unchanged in the urine. This compound may cause adverse health effects at high doses due to its toxicity as a nitrosating agent, which may result in DNA damage or cancer.

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-2-methylcycloheptan-1-one (2C7) is a cyclization agent used in organic synthesis. It is typically used to produce cyclohexyl and cyclopentyl compounds by radical cyclization of hydroperoxides or allylic hydroperoxides. 2C7 can also be used for the regioselective synthesis of substituted 2,4,6-trichlorocyclohexanes from chlorinated alkenes. The efficiency of this reaction has been shown to depend on structural features of the substituents on the alkyne. Treatment with sulfate ions has been shown to affect the reactivity of 2C7.</p>

Versatile small molecule scaffold

<p>2-(Chloromethyl)-5-phenyl-1,3-oxazole is an inhibitor of cholesterol ester transfer protein (CETP) that belongs to the family of amides. It binds to the active site of CETP, preventing it from cleaving cholesteryl esters from HDL and transferring them to LDL. This prevents the formation of cholesteryl ester/LDL complexes, which are believed to be one cause of atherosclerosis. 2-(Chloromethyl)-5-phenyl-1,3-oxazole also inhibits cholesterol synthesis in liver cells by inhibiting HMG CoA reductase.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Oxolan-2-ylmethyl chloroformate is an intermediate in the synthesis of pharmaceutical formulations. It can be used to synthesize various compounds such as nitroso, aliphatic hydrocarbon, formic acid, carbamic acid, aziridine, copper, alkenyl and pyridyl. Oxalan-2-ylmethyl chloroformate is a reactive compound that can react with amides to produce amides.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Methyl-2,3-dihydro-1H-inden-1-ol is a carboxylic acid that can be synthesized from indene. The compound has been found to be reactive with electron microscopes and gas chromatography/mass spectrometers. 1-Methyl-2,3-dihydro-1H-inden-1-ol can be extracted from the following compounds:</p>

<p>Versatile small molecule scaffold</p>