Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methoxy-4-(methylsulfanyl)benzoic acid is a thiazolopyridine prodrug that is converted to its active form, 2-methoxy-4-(methylsulfanyl)benzoyl chloride (MMBC), by esterases. MMBC inhibits the replication of both influenza A and B viruses in cell culture, with an IC50 of 0.5 μM. MMBC also has an inotropic effect on isolated rat cardiomyocytes, which may be due to inhibition of the virus-mediated inhibition of cardiac myosin ATPase activity. The pharmacokinetic properties of MMBC are determined experimentally by administering the drug orally to rats and measuring its concentration in serum. These data show that MMBC has a low oral bioavailability and a short elimination half-life.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

4-(3-Methyl-1H-pyrazol-1-yl)benzoic acid is a potent inhibitor of the human voltage gated sodium channel (Nav). This compound has been shown to inhibit Nav channels at concentrations as low as 10 μM.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione is a heterocyclic organic compound with the chemical formula CHN. It is one of the many pyrrole compounds that are synthesized from phosphorus pentoxide. This heterocyclic compound has been shown to have acylation reactions with tertiary amines and alcohols. 6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione has been found in pharmaceutical preparations and is used as a growth factor for cancer cells. It also has anti-inflammatory properties and can be used for the treatment of inflammatory diseases such as psoriasis.

<p>Versatile small molecule scaffold</p>

N-Methyl-4-phenoxyaniline is a molecule that inhibits chitinase, an enzyme that catalyzes the hydrolysis of chitin, and molting. N-Methyl-4-phenoxyaniline has been shown to be potent inhibitor of the enzyme amide in vitro. It also inhibits onchocerca volvulus and in vivo, which may be due to its ability to inhibit the synthesis of fatty acids. This drug has not been tested against other parasites or mammals, but it is an anthelmintic drug.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadia zol-2-yl)acetamide is a heterologous analog of 5'-aminoacyl tRNA synthetase that can be used to transfer sequence data from one host cell to another. The compound has been found to be useful in the translation of proteins and transfer of genetic information between cells. N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl 1,3,4thiadiazo l 2 yl)acetamide is a substrate for translation by the ribosome and is also capable of binding to the ribosome with high affinity.</p>

<p>6-(Methylsulfanyl)hexanenitrile is a fatty acid that has been used as an antioxidant. 6-(Methylsulfanyl)hexanenitrile is synthesized by the reaction of methylmalonyl-CoA with acetoacetyl-CoA and has been shown to have strong antioxidant activity. It is also found in natural products such as the glucosinolates, which are secondary plant metabolites. 6-(Methylsulfanyl)hexanenitrile is produced by the plant in response to microbial infection, and it can inhibit Candida glabrata growth. It also has antimicrobial properties against other types of fungi.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

1-(Pyridine-3-sulfonyl)piperidine-4-carboxylic acid is a custom synthesis of Modification, Fluorination, Methylation, Monosaccharide, Synthetic. It has CAS No. 697258-71-2 and is a Polysaccharide with Glycosylation. It has complex carbohydrate and sugar.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>5,6,7,8-Tetrahydroquinoline-2-carboxylic acid is a medicament that is used to treat cardiovascular and respiratory diseases. It works by stimulating the production of cyclic guanosine monophosphate (cGMP) in the body. This leads to vasodilation and relaxation of blood vessels, which lowers blood pressure. 5,6,7,8-Tetrahydroquinoline-2-carboxylic acid also stimulates soluble guanylate cyclase, which increases the level of guanylate in cells. This increase can decrease bronchial spasms and improve breathing difficulties caused by asthma or chronic obstructive pulmonary disease.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>(1R,3S,5R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid is a stereoselective and scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid that can be synthesized in a two step sequence with high yield and high stereoselectivity. The cyclopropanation of the carboxylate group with allyl bromide provides the desired product in good yield and high selectivity (&gt;90% ee).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-[(Benzyloxy)methyl]cyclobutan-1-ol is a crystalline solid with a melting point of 174.5°C and density of 0.989 g/mL at 20°C. It has been shown to be an intermediate in the synthesis of various organic compounds, including dichloroketene, benzyl ethers, and allyl ethers. 3-[(Benzyloxy)methyl]cyclobutan-1-ol has been crystallographically characterized by X-ray diffraction and has been shown to undergo cycloaddition reactions with allene or 1,3-butadiene to form hexahydrobenzofurans or tetrahydrofurans, respectively.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-Iodo-5-nitrophenol is an organic compound that is synthesized from the reaction of sodium azide and 2,6-dichloro-4-(trimethylammonium)benzene. The photoluminescence of this compound has been shown to be efficient, with a maximum emission wavelength of 590 nm. This chemical is soluble in a variety of solvents, including cyclodextrin and organic solvents such as acetone. This chemical can also be used in the synthesis of other compounds, such as alkynyl groups or ortho permethylated compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Ethyl 2-(3-bromopyridin-2-yl)acetate is a synthetic compound that has been used in the treatment of cancer. It has been shown to be effective against colon cancer and cancer cell lines. Ethyl 2-(3-bromopyridin-2-yl)acetate binds to DNA and inhibits the activity of topoisomerase II, which is an enzyme that maintains the integrity of DNA. This inhibition leads to disruption of DNA synthesis and replication, leading to cell death. The antitumour activity of this compound is due to its ability to create reactive oxygen species (ROS), which lead to oxidative stress in cells.