Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Naphthalen-2-yl)-2-oxoacetic acid is a naphthalene derivative that can be synthesized by reacting 2-naphthol with ethyl acetate. It has been shown to have a quantum yield of 0.024 and fluorescence emission at 561 nm in aqueous solution. The reaction scheme for the synthesis of 2-(naphthalen-2-yl)-2-oxoacetic acid is as follows:

In the late 1990s, a new chemical compound was discovered with a novel inhibitory effect on tumor growth. This compound is called N,N-dimethyl-2-(phenylamino)acetamide (DPA). DPA has been shown to inhibit tumor growth by preventing the synthesis of glucose. It also inhibits tumor growth in vivo and in vitro. DPA has been found to be effective against cancer cells that are resistant to chemotherapy and radiation therapy. The mechanism of action is not yet known, but it may be related to its ability to bind to sugar molecules or its inhibition of glucose production by pancreatic beta cells.
The structural analysis of this compound is still being studied, but it is thought that it may be derived from either wheat germ or monoclonal antibodies.

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 4-oxoheptanoate (E4OH) is an inhibitor of tyrosine hydroxylase, which converts the amino acid tyrosine to the neurotransmitter L-DOPA. It is a trisubstituted, high stereoselective, and hydroxylase inhibitor. E4OH inhibits the enzyme tyrosine hydroxylase and prevents the synthesis of L-DOPA in a stereospecific manner. This compound also has been shown to inhibit diastereoisomeric synthses of L-DOPA.

2-Isocyanatobicyclo[2.2.1]heptane is a natural product that has been shown to be a potent inhibitor of the soluble epoxide hydrolase and an epoxide hydrolase enzyme, which are responsible for the degradation of epoxides. This compound is structurally similar to aniline and amine compounds, which have been shown to inhibit the virus that causes SARS or severe acute respiratory syndrome (SARS-CoV). 2-Isocyanatobicyclo[2.2.1]heptane has also been shown to inhibit coronavirus, which is one of the most common causes of upper respiratory infections in humans.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Hydroxy-4,5-dimethoxybenzaldehyde (2HMB) is a natural product that belongs to the group of methides. It has been isolated from plants belonging to the genus Neorautanenia. This compound has been shown to inhibit target enzymes such as neorautanenia amboensis, methides, eupatorium, spathulenol, chalcone, benzofuran derivatives and conjugates. 2HMB also inhibits bacterial growth by binding to ribosomes and preventing protein synthesis. 2HMB can be synthesized from corydine or skeletons by borohydride reduction. The skeleton structure of 2HMB is the same as that of the synthetic drug neorautanenia amboensis and is used for treatment of sepsis in humans.

2-(1H-Tetrazol-5-yl)pyridine (TPZ) is a hydrogen bonding molecule that has been extensively used as a probe to study the coordination geometry of metal ions. The TPZ molecule has a trigonal planar structure with three nitrogen atoms and one chloride ligand. The TPZ molecule is a strong base with a pKb value of 8.6, which makes it a good candidate for protonating other molecules. The TPZ molecule can be synthesized in various forms, including the hydrochloride salt form.

4-Bromo-3-methyl-benzenethiol is an experimental compound that belongs to the class of fluorine compounds. It has a molecular weight of 221.8 and a chemical formula of C6H5BrSCH2. 4-Bromo-3-methyl-benzenethiol contains a methoxy substituent, which is located on the central carbon atom. This compound also contains two bromine atoms, which are located on either side of the central sulfur atom. 4-Bromo-3-methyl-benzenethiol has been shown to have sulfhydryl group in its structure, and can form couplings with other molecules through this group.

Prop-2-ene-1-sulfonyl chloride is an organic compound that is used as a pharmaceutical intermediate. It has been shown to have potent inhibitory activity against pancreatic lipase, which makes it a potential treatment for inflammatory diseases such as arthritis. The active form of prop-2-ene-1-sulfonyl chloride binds to the receptor site of the molecule and prevents it from binding with other molecules, thereby blocking the inflammatory response. Prop-2-ene-1-sulfonyl chloride also binds to cholesterol esters in cells and prevents them from being transferred. This inhibits cholesterol production and reduces inflammation caused by high levels of cholesterol.

Benzyl-(4-methoxy-benzyl)-amine is a chemical compound that has the molecular formula CHNO. It is an organic compound with a nitrate group, which are common in esters and phenolates. This compound can be synthesized by debenzylating benzyl amines and reacting them with nitric acid. Benzyl-(4-methoxy-benzyl)-amine may also be prepared by reacting benzaldehyde with ammonium hydroxide or ammonia gas. The synthesis of this compound is chemoselective, meaning it only reacts at one point on the molecule, rather than two. Benzyl-(4-methoxy-benzyl)-amine is used as a precursor to other compounds such as ammonium nitrate, esters, phenolates, and amides.