Building Blocks

3-Fluoronaphthalene-2-carboxylic acid is a nitrile that is derivatized with carboxylic acid, amide, and benzimidazole. It has been shown to be reactive toward radical, carbonyl, halide, and imidoester. 3-Fluoronaphthalene-2-carboxylic acid can also be used in the synthesis of 3-(3'-fluoro)benzoxazinones and related compounds.

Versatile small molecule scaffold

2,3-Naphthalic anhydride is a naphthalene derivative that can be used to synthesize amides, amines and other organic compounds. It is obtained by the reaction of 2,3-dihydroxynaphthalene with a metal halide such as chloride or bromide. This reaction produces 2,3-naphthalic anhydride in high yield. The compound has been used as a precursor for the fluorescent derivative naphthofluorescein and propiolic acid. A synthetic process for this compound was first developed in 1887 by R. Pinner and L. Hahn. The compound has been found to have numerous applications in the production of plastics, textiles and dyes.

Versatile small molecule scaffold

2,6-di(tert-butyl)-4-Nitrobenzenol is a chemical that is used as a reference standard for the gravimetric determination of sodium. It has been shown to have low toxicity in animals and environmental monitoring studies, but can be hazardous if ingested by humans. The LD50 (lethal dose) for 2,6-di(tert-butyl)-4-nitrobenzenol in Sprague Dawley rats is greater than 10 g/kg body weight. This chemical also has the potential to react with pyrimidine nucleosides and organic chemicals such as methylene chloride or urea nitrogen.

Versatile small molecule scaffold

2,2,2-Trichloroethyl chlorosulfate is an organic compound that has a hydroxyl group and a chlorine in its structure. It is cytotoxic to cells and causes health effects in humans. This compound binds to the p-coumaric acid in the cell and inhibits the enzyme activity of the demethylase, which is responsible for the oxidation of p-coumaric acid to ferulic acid. This prevents p-coumaric acid from being converted into other metabolites such as dihydroferulic acid and dihydrocaffeic acid. 2,2,2-Trichloroethyl chlorosulfate also inhibits enzymes involved in the synthesis of cholesterol by competitively inhibiting HMG CoA reductase.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Cyclopentylethanol is a type of organic compound that belongs to the class of ethyl esters. It has been shown to have receptor activity, which may be related to its ability to reduce plasma glucose levels in type 2 diabetes patients. The mechanism by which 2-cyclopentylethanol affects glucose metabolism is not clear, but it has been found to inhibit serine protease and sulfonic acid-induced platelet aggregation. It has also been found to have anti-inflammatory effects and can inhibit the production of inflammatory mediators such as prostaglandin E2 (PGE2). 2-Cyclopentylethanol also inhibits the activity of certain types of enzymes, including pyrimidine hydroxylases and acylureas.

2,5,5-Trimethyl-1,3-dioxane is an organic compound that has a strong odor. It is classified as an aliphatic ketone and has a cyclopropyl group.

Isoxazole compounds are a class of heterocyclic compounds that inhibit the enzyme acetylcholine esterase (AChE) and thus have anticholinesterase activity. Isoxazoles have been shown to be effective in treating bladder and bowel disease, cancer, depression and other neurological disorders. The isooxazole 7-azaspiro[3.5]nonane has been shown to be effective in vitro against fungi. It is a covalent inhibitor of the fungal enzyme β-glucosidase and can also act as an endocannabinoid receptor agonist. 7-Azaspiro[3.5]nonane has not been studied in vivo, but its pharmacokinetic properties suggest it may be useful for treatment of inflammatory bowel disease or depression due to its high bioavailability and long elimination half-life.

2-Ethynyltoluene is an organic compound that has been reported to be reactive with various compounds. This chemical has been shown to inhibit the phosphorylation of tyrosine residues on human insulin receptor, which is a key step in insulin signaling pathways. The phosphate group in 2-ethynyl-toluene can be removed by protonation, allowing the molecule to react with other molecules and form model complexes. This chemical also forms polymers when heated and coated onto surfaces.2-Ethynyltoluene is soluble in polar solvents such as water, alcohols, and acetone.
2-Ethynyltoluene has a molecular weight of 130.1 g/mol and a boiling point of 148°C at 760 mmHg.

Versatile small molecule scaffold

Versatile small molecule scaffold

Dimedone is a ketone that is found in the oils of many plants. It can be synthesized by the transformation of 3,3-dimethylcyclohexan-1-ol with ethynylation and sequence. This reaction sequence has been shown to produce high yields of dimedone.

1-Ethynyl-2,3-dimethylbenzene is a mesoporous material with a large surface area. It has the ability to adsorb large amounts of nitrogen gas and can be used as an adsorbent for the removal of nitrogen from natural gas. The cyclophane is composed of an aromatic ring and a heterocyclic ring, which are connected by a single bond. This compound has been shown to have high emission profiles in the visible region. It also has hysteresis properties due to its microporous nature. 1-Ethynyl-2,3-dimethylbenzene is a polymer that is conjugated, giving it high stacking abilities with other materials.

2-Ethylbenzyl alcohol is a metabolite of the drug 2-ethylhexanol. It is an active antiretroviral therapy that inhibits HIV replication by binding to the RNA polymerase of the virus, thus inhibiting its activity. 2-Ethylbenzyl alcohol has been shown to inhibit hepatitis C virus replication in cell culture and has anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis. This drug also has ferroelectric properties, which can be used as a sensor for kinetic energy.

Versatile small molecule scaffold

1-Methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile is an oxidation product of osmium and phosphorus oxychloride. It has been shown to have a hypoglycemic effect in mice. The mechanism of this effect is unknown, but it may be due to the antioxidant potential of 1-methyl-6-oxo-1,6-dihydropyridine 3 carbonitrile. There are no studies that indicate whether this compound has any effects on humans. This chemical is found in the leaves of a plant called Acalypha wilkesiana and also in the extract from Ricinus communis seedlings and Acalypha wilkesiana seedlings.

Versatile small molecule scaffold

4-Phenyl-1-butene is an aryl halide that undergoes acylation reactions with the addition of hydrochloric acid. The reaction is efficient and produces high yields. 4-Phenyl-1-butene can be used in the synthesis of fosinopril sodium, which is a drug used to treat high blood pressure. The reaction requires hydrogen chloride gas, which reacts with the butene to produce chloride ions as well as sequences containing 4 phenyl groups. 4-Phenyl-1-butene is also used for asymmetric synthesis and copolymerization reactions. Copolymerization reactions are done at low temperatures to avoid polymerization and crosslinking of monomers.

Versatile small molecule scaffold

2-Chloro-6-fluorobenzene-1-carbothioamide is a chemical that is used in the production of insecticides. Research has been done to investigate the insecticidal properties of 2-chloro-6-fluorobenzene-1-carbothioamide and how it can be synthesized in an organic process.

Versatile small molecule scaffold

4,6-Dibromo-2,1,3-benzoxadiazole is an azide compound that is used as a precursor for the synthesis of other compounds. The structure of this molecule consists of two benzene rings with a single oxygen atom in between. It contains four bromine atoms and one fluorine atom. This molecule has an isomeric relationship to 2,1,3-benzoxyazetidine and 2,1,3-benzothiadiazetidine because it has two identical groups on each ring. 4,6-Dibromo-2,1,3-benzoxadiazole can be synthesized by reacting phenols with sodium azide or fluorine atoms in the presence of a catalytic amount of copper(II) chloride.

3-Methyl-3-phenylbutan-2-one is a ketone that is damaging to benzene and horticultural olefinic methoxy. It has been shown to be an antidopaminergic agent and has been used in the kinetic scheme as a competitive inhibitor of dopamine. 3-Methyl-3-phenylbutan-2-one is reactive with chloride, alcohols, and aluminium. This chemical has also been shown to have dehydrating effects on organic substances.

Versatile small molecule scaffold

1-Amino-2-bromonaphthalene is a synthetic compound that is used as a recyclable reagent. It has been shown to have an inhibitory effect on cancer cells and tissue, stabilizing the DNA molecule and preventing it from being broken down. 1-Amino-2-bromonaphthalene also has affinity for cancer cells and stabilizes the cell membrane by inhibiting phosphonate degradation. The drug has been envisaged as a potential candidate for cancer therapy due to its ability to stabilize the cell membrane and inhibit phosphonates, which are involved in cell division.

1-Chloro-4,5-difluoro-2-nitrobenzene is a water soluble, colorless liquid that is soluble in chloroform and reacts with hydrochloric acid to form 1-chloro-4,5-difluoro-2-nitrobenzene hydrochloride. It is a catalyst for the conversion of chloroformates to nitro radicals. 1,4,5-Trichloronitrobenzenes are used as catalysts in the nitration of aromatic compounds. The reaction temperature should be between 0 and 10 degrees Celsius.

1-(tert-Butyl)-4-ethynylbenzene is a ruthenium complex that reacts with terminal alkynes to form an aromatic hydrocarbon. The reaction system is homogeneous and the catalyst is a coordination geometry, which is electron microscopic and reactive. 1-(tert-Butyl)-4-ethynylbenzene has been shown to be nonpolar solvents such as benzene, chloroform, ether, or hexane. It also emits light when excited by ultraviolet radiation.

(3,3,3-Trifluoroprop-1-yn-1-yl)benzene is a reaction product that can be used to inhibit the activity of metalloprotease and as an anti-cancer agent. This compound inhibits the enzyme that causes chronic kidney disease and degenerative diseases. It is a potent inhibitor of metalloprotease, which is involved in cancer progression, fatty acid synthesis and bone formation. The effective dose for this drug is between 1 and 10mg/kg body weight. It has been shown to have an asymmetric synthesis with the use of amido groups. (3,3,3-Trifluoroprop-1-yn-1-yl)benzene also has antirheumatic properties due to its ability to inhibit proteases such as matrix metalloproteinases and cathepsins.

Versatile small molecule scaffold

1-Benzyl-2-methylpyrrolidine is a chemical reagent that is used in organic synthesis as an oxidant, dehydrogenation agent, and alkylation agent. 1-Benzyl-2-methylpyrrolidine is also used to generate amines from thioacetals and anilines. It can be used to synthesize carbonyl compounds via the oxidation of alcohols with hydroxylamine or sodium carbonate. This chemical reagent has been shown to catalyze the aromatization of benzene derivatives with Raney nickel or cyclic systems. Furthermore, it has been shown to inactivate various types of microorganisms such as bacteria and yeast cells by reacting with their enzymes.

Versatile small molecule scaffold

Versatile small molecule scaffold