Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-2-fluoro-1-methylcyclopropane-1-carboxylic acid is an aralkyl halogen with bactericidal, fungicidal and potassium permanganate properties. It is also used as a diluent for potassium permanganate. Potassium permanganate oxidizes 2-chloro-2-fluoro-1-methylcyclopropane-1 carboxylic acid to the corresponding hydroxyl compound, which reacts with alkoxy groups in the cell membrane to produce a cyclopropane ring. This reaction leads to cell death by inhibiting protein synthesis and DNA replication.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 2-methylbenzo[D]oxazole-4-carboxylate is a potent inhibitor of the polymerase enzyme, which plays a central role in DNA replication. It has been shown to have anticancer activity and can be used as an adjuvant therapy for cancer. The inhibitory effect of methyl 2-methylbenzo[D]oxazole-4-carboxylate on polymerase can be potentiated by other drugs such as adenosine-5'-diphosphoribose (ADP) and carboplatin. Methyl 2-methylbenzo[D]oxazole-4-carboxylate binds to the active site of polymerase through hydrogen bonding, inhibiting the synthesis of DNA. This drug also stabilizes the conformation of the enzyme's active site, which may lead to increased rates of catalysis. The reactive nature of methyl 2-methylbenzo [D] oxazole 4 car

Versatile small molecule scaffold

1-Phenyl-3-pyrrolidinone (1PP) is a cytotoxic agent that inhibits the growth of tumor cells. It has been shown to have activity against leukemia, lymphocytic leukemia, and human colon adenocarcinoma cells. The 1PP binds to the phenyl ring and interacts with DNA in a manner similar to adriamycin. This binding blocks DNA synthesis, leading to cell death by apoptosis. 1PP is resistant to leucovorin, which is an antagonist of adriamycin and other chemotherapeutic agents. In vitro studies have shown that 1PP exhibits cytotoxicity against promyelocytic leukemia Hl-60 cells and Molt-4 cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Morpholine is a five-membered heterocyclic compound with the molecular formula CHN. It is a colorless solid that is soluble in water, ethanol and ether. Morpholine is an intermediate in the production of carbamates, urea, and other organic chemicals. It can be converted to 5-chloropyridine-2-carbonyl chloride by condensation with hydrobromic acid and chlorination. This reaction requires high yield and high purity morpholine as an intermediate.

2-(3-Methyl-2,4,5-trioxoimidazolidin-1-yl)acetic acid is a potent activator of the GABAA receptor and an inhibitor of glutamate release. It has been observed to increase GABAergic neurotransmission in the brain and to inhibit protein interactions. In addition, 2-(3-Methyl-2,4,5-trioxoimidazolidin-1-yl)acetic acid can be used as a research tool for studying ion channels and peptides.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Ethynyl-2-(methylsulfanyl)benzene is a potent antioxidant. It has been shown to have antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as antifungal activity against both mold and yeast. 1-Ethynyl-2-(methylsulfanyl)benzene has been shown to inhibit the growth of S. aureus and E. coli in vitro, having an IC50 of less than 0.1 μg/mL. This compound also inhibits the growth of Bacillus subtilis and B. cereus, with IC50 values of 0.5 and 0.06 μg/mL respectively, but is not active against Escherichia coli or Pseudomonas aeruginosa at concentrations up to 200 μg/mL.