Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

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Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1,4-Benzodioxine-2-carboxylic acid is a synthetic compound that is a member of the c1-6 alkyl group. It has been synthesized in four different stereoisomers, including cis and trans isomers. 1,4-Benzodioxine-2-carboxylic acid has potent inhibitory effects on protein synthesis in cell preparations at multigram concentrations. It also inhibits the activity of translation or replication of DNA or RNA by binding to the active site of the enzyme ribonuclease H and inhibiting its cleavage at the 3'-terminal nucleotide bonds. The trifluoromethyl group on 1,4-benzodioxine-2-carboxylic acid may be responsible for some of its biological properties. Molecular modeling studies have shown that 1,4 benzodioxine carboxylic acid binds to DNA through hydrogen bonding with one water molecule and two guanidine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Dimethylcarbamoyl)acetic acid is a heterocyclic compound that contains a 5-membered, nitrogen-containing heterocycle. This molecule is used in the synthesis of pharmaceuticals and other organic compounds.

Tetrahydro-1-benzofuran is a heterocyclic compound with the chemical formula C4H6O. It is a furan derivative, and is classified as an alkylene. Tetrahydro-1-benzofuran has been shown to have anti-amnesic properties in animal studies for Alzheimer's disease. It also has been found to be useful as a reagent for organic synthesis. Tetrahydro-1-benzofuran can be used as a starting material for the synthesis of other heterocyclic compounds such as pyrrole and furanosesquiterpenes.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Chloro-2H-chromen-2-one is an organic compound that is used as a building block in the synthesis of coumarin derivatives. It undergoes nucleophilic substitution reactions with amines, forming 4-hydroxycoumarin. This reaction is catalyzed by organometallic compounds such as PdCl2 and Cu(OAc)2. Cross-coupling reactions have been shown to be effective for the synthesis of coumarin derivatives. The mechanism of this reaction involves oxidative addition of an organometallic reagent to the carbon atom, followed by elimination of water to form an intermediate epoxide. Deuteration is required for this reaction because hydrogen reacts too rapidly with the organometallic reagents to be useful in the coupling process. 4-Chloro-2H-chromen-2-one has been shown to react with other nucleophiles such as thiols, phenols, and alcohols at

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(4-Bromophenyl)propan-2-amine (BPAP) is an analogue of the antihistamine diphenhydramine. The BPAP analogues are selective for protein kinases, such as vegfr-2, cyclin, and cdk1. VEGFR-2 is a receptor tyrosine kinase that is activated by vascular endothelial growth factor and plays a role in angiogenesis. Cyclin is a serine/threonine protein kinase that regulates the cell cycle and CDK1 regulates the progression from G1 to S phase. In vivo efficacy studies have shown that BPAP inhibits these three kinases with an IC50 value of less than 1 μM in human tumor cells.

Cyclohexyl(cyclopentyl)methanone is a benzonitrile derivative with a cyclopentyl and cyclohexyl side chain. It can be synthesized by the reaction of phenylmagnesium bromide with methyl benzoate in the presence of sodium borohydride. Cyclohexyl(cyclopentyl)methanone is used as a reagent for the conversion of ketones to aminoketones, and can also be used in hydrolysis reactions involving Grignard reagents.

2-Chloro-N-(2-cyanoethyl)acetamide is a potent and selective inhibitor of the protein kinase C (PKC). The PKC protein kinases are enzymes that regulate the activity of cells in response to stimuli. 2-Chloro-N-(2-cyanoethyl)acetamide has been shown to be effective against some viruses and tumor cells, but not against bacteria. It inhibits the growth of some cancer cells and has been shown to inhibit the replication of animal viruses such as influenza virus. This drug is also used for treatment of abdominal infections, hepatitis, pancreatitis, mesenteric adenitis, and animals with cancer. 2-Chloro-N-(2-cyanoethyl)acetamide can act as a noncompetitive inhibitor by binding to a site on the enzyme that is different from ATP binding site.

Versatile small molecule scaffold

3-Cyclohexyl-1-propyne is a molecule that has been synthesized using palladium-catalyzed coupling. This compound has been shown to inhibit the growth of staphylococcus, and other bacteria, by inhibiting pyrazole synthesis. 3-Cyclohexyl-1-propyne can also be used for the preparation of conjugates with chemical species such as hydroxy groups. The use of homogeneous catalysts and the use of stereoselective reactions have made this process highly efficient.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,5-Dioxopyrrolidin-1-yl formate is a solubilized ATP analog that has been clinically developed for the treatment of cancer. This drug binds to cell membranes and causes alkylation of the acidic phospholipids in the membrane, leading to increased permeability of the membrane and release of intracellular components. 2,5-Dioxopyrrolidin-1-yl formate also interacts with lysosomes and increases their acidity, which may lead to an increase in lysosomal enzyme activity. This drug has been shown to inhibit tumor growth in a mouse model by binding to erythrocytes while it was being simultaneously administered intravenously. The chemical structures of this drug are closely related to those of phaseolus, which is known for its anticancer effects.

N,N-Dimethylcyclohexanecarboxamide is an acid salt of besylate that is used as a drug for the treatment of hyperglycemia. It has been shown to have a rapid onset and short duration of action. The chemical name for N,N-Dimethylcyclohexanecarboxamide is 1-[2-(2-methoxyethoxy)ethyl]-4-methyl-1,4-dihydropyridine 2,4-dicarboxylic acid methyl ester. This compound inhibits insulin release from the pancreas and stimulates glucagon release from the alpha cells in the pancreas. These effects lead to an increase in blood glucose levels.

Versatile small molecule scaffold

2-(Naphthalen-1-yl)ethanethioamide is a phytohormone that belongs to the class of ethylene. It is involved in the regulation of many processes, including apical dominance, peduncle elongation, leaf senescence, and fruit ripening. 2-(Naphthalen-1-yl)ethanethioamide is an active form of ethylene that binds to the receptor protein ETR1. This binding stimulates the synthesis of proteins that regulate these processes. It has been shown to be effective in treating flowers with inflorescence stems and fruits with peduncles. The transformation process may involve hydrocarbon molecules with long aliphatic chains.

5-(Trifluoromethyl)-2-furaldehyde is a trifluoroacetate that is used for the trifluoromethylation of organic compounds. It can be used to produce 5,5-difluoro-2-pentanol, which is an organic solvent. The reaction proceeds through an electrophilic substitution mechanism.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(4-Chlorophenyl)-1H-imidazole-2(3H)-thione is a crystalline solid that belongs to the class of imidazoles. It has been synthesized by reacting 1,2-dibromoethane with sodium methoxide in methanol. The compound was found to have a melting point of about 183°C and a molecular weight of 212.06 g/mol. This compound has been shown to interact with methanol, methoxide, and ethoxy groups. Crystallization occurs when the substance is heated to about 183°C in vacuum and then cooled slowly.

Versatile small molecule scaffold