Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

PB-22 is a synthetic cannabinoid, which can be classified as a CB1 receptor agonist. It is one of the many cannabinoids that have been created in an attempt to circumvent drug laws by creating compounds that are similar to those found in cannabis but have different chemical structures. PB-22 has shown to increase locomotor activity and stimulate the cb1 receptor in mice. Magnetic resonance spectroscopy (MRS) and assays were used to determine the binding affinity of PB-22 for the CB1 receptor. The MRS data showed that PB-22 bound with high affinity to the CB1 receptor and had a lower affinity for CB2 receptors. This suggests that PB-22 may be more potent than other synthetic cannabinoids, such as JWH-018 and CP 55,940, which bind better with CB2 receptors than CB1 receptors.
PB-22 is an analog of JWH-073 and has been shown to have a stronger effect on locomotor activity than JWH

Versatile small molecule scaffold

1-Chloroisoquinolin-4-ol is a phenylpyrimidine with anti-inflammatory properties. It is used in the treatment of sensitivity and mediated diseases, such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. 1-Chloroisoquinolin-4-ol inhibits the enzymatic activity of matrix metalloproteinases (MMPs), which are enzymes that break down collagen and other proteins in the body. The inhibition of MMPs by 1-chloroisoquinolin-4-ol leads to reduced inflammation and pain. This compound is also an effective inhibitor of the activities of chloride channels involved in acid secretion by cells in the stomach lining, thus inhibiting acid production. 1-Chloroisoquinolin-4-ol has been shown to have anticholesterolemic effects on liver cells due to its ability to inhibit cholesterol synthesis through inhibition of HMG CoA

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Please enquire for more information about Diisopropylphosphine, 10wt.% in hexane including the price, delivery time and more detailed product information at the technical inquiry form on this page

Versatile small molecule scaffold

Versatile small molecule scaffold

5-(3-Methylthiophen-2-yl)-1,3,4-oxadiazol-2-amine is a ligand that binds to the ion channels in cells and activates them. It is used as a research tool in pharmacology and protein interactions. 5-(3-Methylthiophen-2-yl)-1,3,4-oxadiazol-2-amine has been shown to activate potassium channels by interacting with the receptor site. This ligand was also shown to inhibit cell growth by binding to the antibody site of the receptor. 5-(3-Methylthiophen-2-yl)-1,3,4--oxadiazol-2--amine has been shown to have a high purity of 99%.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(S)-(+)-1-Bromo-2-methylbutane is a chiral molecule with two stereoisomers, the cis and trans forms. The cis form has been observed to be the more stable of the two. It is a functional theory that these two forms are not mirror images of each other because they have different conformations. (S)-(+)-1-Bromo-2-methylbutane has been used in the synthesis of a number of important molecules. The stereoisomers can be distinguished by conformational analysis and optical microscopy. (S)-(+)-1-Bromo-2-methylbutane also has an application in biotechnology for use as a precursor for hydrazones, which are important in organic chemistry and molecular biology, such as DNA sequencing.

2-Chloro-N-(2-cyanoethyl)acetamide is a potent and selective inhibitor of the protein kinase C (PKC). The PKC protein kinases are enzymes that regulate the activity of cells in response to stimuli. 2-Chloro-N-(2-cyanoethyl)acetamide has been shown to be effective against some viruses and tumor cells, but not against bacteria. It inhibits the growth of some cancer cells and has been shown to inhibit the replication of animal viruses such as influenza virus. This drug is also used for treatment of abdominal infections, hepatitis, pancreatitis, mesenteric adenitis, and animals with cancer. 2-Chloro-N-(2-cyanoethyl)acetamide can act as a noncompetitive inhibitor by binding to a site on the enzyme that is different from ATP binding site.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,5-Dioxopyrrolidin-1-yl formate is a solubilized ATP analog that has been clinically developed for the treatment of cancer. This drug binds to cell membranes and causes alkylation of the acidic phospholipids in the membrane, leading to increased permeability of the membrane and release of intracellular components. 2,5-Dioxopyrrolidin-1-yl formate also interacts with lysosomes and increases their acidity, which may lead to an increase in lysosomal enzyme activity. This drug has been shown to inhibit tumor growth in a mouse model by binding to erythrocytes while it was being simultaneously administered intravenously. The chemical structures of this drug are closely related to those of phaseolus, which is known for its anticancer effects.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(2-Hydroxyethyl)-2,6-dimethoxyphenol is a phenolic compound that can be extracted from the bark of the Indian tree Terminalia arjuna. The extract has been used in traditional medicine for centuries to treat diabetes and cancer. In vitro studies have shown that this extract inhibits the activity of viruses, including HIV, with a mechanism of action similar to that of indinavir. 4-(2-Hydroxyethyl)-2,6-dimethoxyphenol also has an antioxidant effect and stimulates the production of glutathione reductase and superoxide dismutase by cells in culture. 4-(2-Hydroxyethyl)-2,6-dimethoxyphenol is used as an herbal drug in India and research has found it to be hepatoprotective when administered orally to rats.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 4-aminonicotinate is a cyclic amine with a chemical formula of C6H11NO2. It has a molecular weight of 117.07 g/mol, and its molecular structure consists of an ethyl group attached to the amino group. The molecule has three resonance peaks in the infrared spectrum at 2,617cm-1 (ν(C=O)), 1,906cm-1 ((C=N)), and 1,723 cm-1 (ν(NH)). In addition to these peaks, the molecule also has two magnetic resonance peaks at 2.24ppm (δ) and 3.38ppm (δ). This compound is soluble in water and can be used as an intermediate in organic synthesis or pharmaceuticals.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4H,5H-Pyrazolo[1,5-a]quinazolin-5-one is a class of heterocyclic compounds that inhibit the parp-1 and parp proteins. These inhibitors are low nanomolar to nanomolar in potency and have been synthesized from chloride and amides. They have been shown to be potent inhibitors of the growth of cancer cells.

1-Benzothiophene-5-carbonitrile is a heterocyclic compound that is formed by condensation of ethyl azidoacetate with indole under catalysis. It can be used in the synthesis of heterocycles. The yield of 1-benzothiophene-5-carbonitrile is about 56%.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold