Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-5-nitroquinoline is an oxidized aminoquinoline that is synthesized from nitric acid and benzene. It contains a nitro group, which makes it susceptible to oxidation. 2-Chloro-5-nitroquinoline is used as a solvent for rubber, plastics, and waxes. It can also be used as a solvent in the production of quinolines and other nitrogen compounds. Nitration of this compound produces 2-chloroquinoline, which can be transformed into 2-chloroquinolinium hydroxide by reaction with sodium hydroxide. The substituent on the ortho position can be determined by oleum or bromine water.

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(4-Chlorophenyl)-1H-imidazole-2(3H)-thione is a crystalline solid that belongs to the class of imidazoles. It has been synthesized by reacting 1,2-dibromoethane with sodium methoxide in methanol. The compound was found to have a melting point of about 183°C and a molecular weight of 212.06 g/mol. This compound has been shown to interact with methanol, methoxide, and ethoxy groups. Crystallization occurs when the substance is heated to about 183°C in vacuum and then cooled slowly.

Versatile small molecule scaffold

N,N-Dimethylcyclohexanecarboxamide is an acid salt of besylate that is used as a drug for the treatment of hyperglycemia. It has been shown to have a rapid onset and short duration of action. The chemical name for N,N-Dimethylcyclohexanecarboxamide is 1-[2-(2-methoxyethoxy)ethyl]-4-methyl-1,4-dihydropyridine 2,4-dicarboxylic acid methyl ester. This compound inhibits insulin release from the pancreas and stimulates glucagon release from the alpha cells in the pancreas. These effects lead to an increase in blood glucose levels.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,5-Dioxopyrrolidin-1-yl formate is a solubilized ATP analog that has been clinically developed for the treatment of cancer. This drug binds to cell membranes and causes alkylation of the acidic phospholipids in the membrane, leading to increased permeability of the membrane and release of intracellular components. 2,5-Dioxopyrrolidin-1-yl formate also interacts with lysosomes and increases their acidity, which may lead to an increase in lysosomal enzyme activity. This drug has been shown to inhibit tumor growth in a mouse model by binding to erythrocytes while it was being simultaneously administered intravenously. The chemical structures of this drug are closely related to those of phaseolus, which is known for its anticancer effects.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-N-(2-cyanoethyl)acetamide is a potent and selective inhibitor of the protein kinase C (PKC). The PKC protein kinases are enzymes that regulate the activity of cells in response to stimuli. 2-Chloro-N-(2-cyanoethyl)acetamide has been shown to be effective against some viruses and tumor cells, but not against bacteria. It inhibits the growth of some cancer cells and has been shown to inhibit the replication of animal viruses such as influenza virus. This drug is also used for treatment of abdominal infections, hepatitis, pancreatitis, mesenteric adenitis, and animals with cancer. 2-Chloro-N-(2-cyanoethyl)acetamide can act as a noncompetitive inhibitor by binding to a site on the enzyme that is different from ATP binding site.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 2-hydroxy-4-methylvalerate is an organic compound that belongs to the class of fatty acids. It is a colorless liquid with a fruity odor. Methyl 2-hydroxy-4-methylvalerate has been shown to inhibit the formation of reactive oxygen species and has antioxidant potential. It also inhibits bone resorption, which may be due to its ability to reduce levels of isobutyric acid in rats and humans. Methyl 2-hydroxy-4-methylvalerate has been found in tropical fruits such as mangoes, durians, and papayas.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Thiomorpholine-4-sulfonyl)-1H-pyrrole-2-carboxylic acid is a peptide that belongs to the class of sulfonamides. It is an activator of ion channels and receptors, which may be useful in the study of life sciences and pharmacology. This compound has been shown to inhibit protein interactions by binding to receptor sites on cells and ligand sites on proteins. 4-(Thiomorpholine-4-sulfonyl)-1H-pyrrole-2-carboxylic acid also binds to the antibody, which enhances the immune response in animals by increasing the production of antibodies against bacterial antigens.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-(3-Cyanophenyl)acetamide is a hydrogen-bonding molecule that has been detected in the gas phase. It has also been observed to interact with water, forming hydrogen bonding interactions and solvatochromism. The equilibrium of N-(3-cyanophenyl)acetamide can be shifted by changing the solvent conditions and pH. This molecule has three conformations when it is in the gaseous phase, including a planar conformation. In addition, N-(3-cyanophenyl)acetamide can be used as a probe for determining hydrogen bonding interactions and conformations due to its ability to form hydrogen bonds with other molecules.

Versatile small molecule scaffold

n-Butyrylglycine is a compound that was first identified in human urine as a metabolite of the amino acid glycine. It is an intermediate in the conversion of glycine to succinic acid, which is required for the production of energy in mitochondria. Deficiency of this enzyme causes mitochondrial dysfunction and leads to various metabolic disorders including fatty acid oxidation disorders and homocysteine metabolism defects. n-Butyrylglycine can be detected by gas chromatography or liquid chromatography with mass spectrometry detection.

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 1-amino-1-cyclobutanecarboxylate monohydrochloride is a cyclic carbonyl compound that is used as a building block in organic synthesis. It has been used to synthesize a number of natural products, such as piperarborenine and cyclobutanes. This compound can be synthesized by reacting ethyl chloroformate with cyclobutanecarbaldehyde in the presence of an acid or base catalyst. The steric and geometric properties of this molecule are highlighted below.

Versatile small molecule scaffold

2-Cyclopentyloxy-benzaldehyde has potent inhibitory activity against inflammatory diseases. It is a chemical compound that contains an amido group and two cyclopentyloxy groups. 2-Cyclopentyloxy-benzaldehyde inhibits the activation of glycogen synthase kinase-3, which is a protein that regulates inflammation in the body. This substance can be used to inhibit the spread of HIV or viral infections by inhibiting protein synthesis in these viruses. 2-Cyclopentyloxy-benzaldehyde also has an inhibitory effect on cachexia, which is a condition characterized by weight loss, muscle wasting, and fatigue.

3-(Methylsulfonyl)benzyl alcohol is a ketone that inhibits the catalytic hydrogenation of benzyl groups. It also has been shown to be an antagonist of β-adrenergic receptors. 3-(Methylsulfonyl)benzyl alcohol is used as a catalyst in catalytic bromination and has also been shown to have anti-inflammatory properties.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Amino-N-(4-methoxyphenyl)benzamide is a catalytic sulfamate that has been optimized for use in the synthesis of benzimidazole derivatives. 4-Amino-N-(4-methoxyphenyl)benzamide is used as a reagent for the preparation of aldehydes from sulfamic acid and various types of carboxylic acids. The reaction mechanism involves nucleophilic attack by the hydroxyl group from the sulfamate on the carbonyl carbon atom to form an intermediate, which then reacts with water to release hydrogen sulfate and form a new double bond.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Trifluoromethyl)benzyl mercaptan is a chemical that has been used as an additive to organic solar cells. It has been shown to improve the performance of these devices by reducing interfacial recombination and increasing electron mobility. This chemical also has semiconducting properties, which have been demonstrated by its ability to be translated in an electron microscope. In addition, 4-(Trifluoromethyl)benzyl mercaptan interacts with many solvents, such as chloroform and dichloromethane, leading to changes in their properties.

Versatile small molecule scaffold

Tetrahydroquinolin-2(1H)-one is a hydrobromide that has been found in the environment as an environmental pollutant. Tetrahydroquinolin-2(1H)-one is used to synthesize amides and has been studied by single-crystal x-ray diffraction. The molecule is centrosymmetric, with a molecular weight of 244.06 g/mol. Tetrahydroquinolin-2(1H)-one can be used as a ligand for metals such as chlorine and magnesium. It does not dissolve in water but does dissolve in organic solvents such as ethers, chloroform, or benzene.

Versatile small molecule scaffold

Versatile small molecule scaffold