Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Methyl-4-phenylpiperidine is a potent and selective antagonist of the l-type calcium channel. It blocks the opening of these channels, which are responsible for the excitation of nerve cells and contraction of muscle cells. 4-Methyl-4-phenylpiperidine has been shown to decrease blood pressure in animals by blocking the release of norepinephrine from sympathetic nerves. The drug has also been shown to be an antidepressant in animal models, but its effects on humans have not been studied.

5-(Pyrrolidin-1-yl)pyridine-2-carbonitrile is a factor receptor antagonist. It has been shown to inhibit the growth of tumor cells and to prevent hair loss in mice by blocking the epidermal growth factor receptor (EGFR). 5-(Pyrrolidin-1-yl)pyridine-2-carbonitrile is used for diagnosis, treatment, and prevention of EGFR transforms. The compound can also be used in multimedia to measure the connectivity between cells and monitor their growth, as well as being rechargeable and chiral. This drug has been tested on animals with devices.

Versatile small molecule scaffold

Mal-PEG1-acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Mal-PEG1-acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Versatile small molecule scaffold