Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Chloro-3,3-dimethylpentan-2-one is an organic compound that has the chemical formula CHClO. It is a colorless liquid with a sweet odor. 1-Chloro-3,3-dimethylpentan-2-one is used in the production of refrigerants and as a solvent for fats and oils. The melting point of this compound is -47°C and it boils at 135°C. It has a high volatility, which explains why it can be found in the air we breathe. This chemical does not react with water or dissolve in water but reacts with acids to produce hydrogen chloride gas.

1-Oxa-3,9-diazaspiro[5.5]undecan-2-one is a carbamate that has shown to be an antagonist of the androgen receptor. In vitro studies show that 1-Oxa-3,9-diazaspiro[5.5]undecan-2-one inhibits the proliferation of cells in hyperproliferative disorders. This compound has been shown to have antiviral effects against herpes simplex virus type 1 (HSV1) and 2 (HSV2). The antiviral potency of this drug is increased by template mutation in the viral genome.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1,4-Benzodioxine-2-carboxylic acid is a synthetic compound that is a member of the c1-6 alkyl group. It has been synthesized in four different stereoisomers, including cis and trans isomers. 1,4-Benzodioxine-2-carboxylic acid has potent inhibitory effects on protein synthesis in cell preparations at multigram concentrations. It also inhibits the activity of translation or replication of DNA or RNA by binding to the active site of the enzyme ribonuclease H and inhibiting its cleavage at the 3'-terminal nucleotide bonds. The trifluoromethyl group on 1,4-benzodioxine-2-carboxylic acid may be responsible for some of its biological properties. Molecular modeling studies have shown that 1,4 benzodioxine carboxylic acid binds to DNA through hydrogen bonding with one water molecule and two guanidine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Amino-N-(2-aminophenyl)-benzamide (4ANAP) is a small molecule that inhibits inflammatory bowel disease. It has been shown to have anti-inflammatory effects and to be a potential biomarker for colorectal adenocarcinoma. 4ANAP binds to the EGF receptor on the cell surface, which prevents its activation by EGF and thereby blocks cellular proliferation. 4ANAP has been shown to bind with high affinity to other receptors such as those found in autoimmune diseases and cancer cells. The anti-inflammatory properties of 4ANAP are due to its ability to inhibit the production of proinflammatory cytokines such as IL1β, IL6, TNFα, and IL8. This drug also inhibits the production of reactive oxygen species in neutrophils and macrophages, thereby reducing oxidative injury in inflamed tissues.

Versatile small molecule scaffold