Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Iodo-1-benzofuran is an organic compound with a linear structure and a phenyl group. It has one hydrogen bond, two of which are stabilized by the phenyl ring. The other three hydrogen bonds are stabilized by the halogen bonds. The benzofuran ring is rotated in such a way that the substituents on it are dihedral. 5-Iodo-1-benzofuran has been shown to have a crystal structure that is stabilized by the halogen bond between the phenyl group and iodine.

Versatile small molecule scaffold

3-Chloro-N-methyl-2-nitroaniline is an antibiotic that belongs to the group of quinolone antibiotics. It has a broad spectrum against Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. 3-Chloro-N-methyl-2-nitroaniline binds to bacterial DNA gyrase and topoisomerase IV, as well as human DNA gyrase and topoisomerase II, inhibiting their activity. This leads to cell death by interfering with the production of proteins vital for cell division. The optimal parameters for this drug have been found using isothermal titration calorimetry on the enzyme gyrase in the presence of different concentrations of 3CMA. Pharmacological targets for this drug include DNA gyrase and topoisomerase IV.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Chrysanthemic acid is a chiral molecule that has been shown to have anti-inflammatory properties. The hydroxyl group in the molecule reacts with malonic acid, forming a chrysanthemic ester. Chrysanthemic acid is also known as an analytical method for determining the degree of unsaturation of fatty acids. Chrysanthemic acid is used in the synthesis of monoclonal antibodies, which can be applied for the treatment and prevention of diseases such as cancer, rheumatoid arthritis, Crohn's disease, and other autoimmune disorders. It can also be used to treat infections caused by bacteria that are resistant to antibiotics. The basic structure of chrysanthemic acid is an inorganic acid that contains a hydroxyl group and an asymmetric carbon atom.