Building Blocks

<p>Applications 1,3-Diethynylbenzene (cas# 1785-61-1) is a useful research chemical.<br></p>

<p>Applications Cyanoacetamide has been used in photometric and fluorimetric postcolumn labeling.<br>References Honda S., et. al.: Anal. biochem., 134, 483(1983)<br></p>

<p>Applications Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present severe side effects.<br>References Abuin, G., et al.: Mol. Biochem. Parasitol ., 35, 229 (1989), Arora, P., et al.: J. Biol. Chem., 270, 6042 (1995), Campos, M., et al.: J. Immunol., 167, 416 (2001), Faundez, M., et al.: Antimicrob. Agents Chemother., 49, 126 (2005),<br></p>

<p>Applications p-Toluoyl chloride is an aromatic compound used as a reagent to synthesize (+)-Yashabushitriol, a plant metabolite that is naturally found in the male flowers of Alnus sieboldiana matsum. p-Toluoyl chloride is also used as a reagent to prepare derivatives of Desloratadine (D290250). Desloratadine is a selective H1-receptor antagonist that has anti-inflammatory effects and is used to treat patients with allergic rhinitis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berger, W.. et al.: Ann. All. Asth. Immun., 89, 485 (2002); Fang, Z., et al.: Tetrahedron Lett., 54, 6834 (2013); Feldman, K. &amp; Simpson, R.: Tetrahedron Lett., 30, 6985 (1989); Mu, S., et al.: Chin. Chem. Lett., 24, 531 (2013)<br></p>

<p>Applications Benzotriazole-5-carboxylic acid (cas# 23814-12-2) is a useful research chemical.<br></p>

<p>Applications 7-Chloro-4-(piperazin-1-yl)quinoline is a metabolite of Piperaquine phosphate (P480050), a low toxicity and quick acting antimalarial drug that is used to treat malaria.<br>References Aditya, S.: J. Drug Dis. Ther., 1, No pp. given (2013); Ahmed, T., et al.: J. Clin. Pharm., 48, 166 (2008); Gargano, N.,et al.: Trop. Med. Int. Health, 16, 1466 (2011)<br></p>

<p>Applications Dibenzyl Phosphite is used in the preparation of phenylalkylphosphonamidates which are then used as probes for a hydrophobic binding register in prostate-specific membrane antigen.<br>References Maung, J. et al.: Bioorg. Med. Chem., 12, 4969 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications 4-O-Methyl-D-glucuronic acid (cas# 2463-49-2) is a useful research chemical.<br></p>

<p>Applications Dimethyl Yellow can induce cytochrome P-448, monooxygenase activities and UDPGT activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fujita, S., et. al.: Chem-Biol. Interact., 52, 15 (1984);<br></p>

<p>Applications A chelating agent, forming complexes with most metal ions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References El-Didamony, A., et al.: Drug Test. Anal., 2, 122 (2010), Chan, A., et al.: J. Med. Chem., 53, 3086 (2010), Ehrman, T., et al.: Bioorg. Med. Chem., 18, 2204 (2010),<br></p>

<p>Applications N-Benzoyl Isothiocyanate (cas# 532-55-8) is a compound useful in organic synthesis.<br></p>

<p>Applications [2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-1-yl]acetic acid (cas# 1171565-50-6) is a useful research chemical.<br></p>

<p>Applications 2-Nitrosopyridine is a useful reactant in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Xing, et al.: J. of Org. Chem., 84(7), 4402-4412 (2019);Zhang, Jingchuan, et al.: Chem. - A Euro. J., 24(17), 4289-4293 (2018)<br></p>

<p>Applications Tazarotenic Acid Methyl Ester is a tazarotene (T010050) related compound, which functions as an acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ. Antiacne; antipsoriatic. Used in treatment of photodamaged skin.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>

<p>Applications A novel medical application of isothiocyanate ester in treating various leukemia, with low toxicity, which includes benzyl isothiocyanate, phenylethyl isothiocyanate, allyl isothiocyanate, sulforaphane, and erucin. Benzyl isothiocyanate (BITC) inhibits the growth of human pancreatic cancer cells by inducing apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kubinyi, H., et al.: J. Cancer Res. Clin. Oncol., 116, 529 (1990), Sheridan, R., et al.: J. Med. Chem., 50, 3173 (2007), Sahu, R.P., et al.: Carcinogenesis, 30, 1744 (2009),<br></p>

<p>Applications 2-Bromo-1-propanol is used in the epoxide productions from Flavobacterium.<br>References Geigert, J., et al.: Appl. Environ. Microbiol. Applied<br></p>

<p>Applications 4-Methoxyphenylacetic Acid is a compound that was found from microbial phenolic metabolites in human feces after the consumption of gin, red wine and dealcholized red wine.<br>References Jimenez-Giron, A., et. al.: J. Arg. Food Chem., 61, 3909 (2013);<br></p>

<p>Applications Ethyl 4-Bromobutanoate is a building block which has been used as a reactant for the preparation of firefly luciferase inhibitor-conjugated peptide derivatives.<br>References Poutiainen, P.K., et. al.: Bioconjugate Chem., 25, 4 (2014)<br></p>