Building Blocks

<p>Stability Hygroscopic<br>Applications Nitrosophenidylate is an N-nitroso derivative of Methylphenidate Hydrochloride(M325880), which is a controlled substance (stimulant). CNS stimulant. Four isomers of Methylphenidate are known to exist. One pair of threo isomers and one pair of erythro are distinguished, from which only d-threo-Methylphenidate exhibits the pharmacologically usually desired effects. This compound is a 4:1 mixture of rac-erythro (M325670) and rac-threo (M325671).<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>

<p>Applications: Intermediate in the preparation of Propantheline Bromide.<br></p>

<p>Applications Isoamyl 4-Methoxycinnamate is used in the highly protective sunscreen composition against the UVA/UVB.<br>References Cuderman, P., et al: Anal. Bioanal. Chem., 387, 1343 (2007), Zhao, X., et al.: Environ. Sci. Technol., 42, 1201 (2008), Dubrovski, P., et al.: Text Res. J., 79, 351 (2009),<br></p>

<p>Applications 2-Chloro-N-(hydroxymethyl)acetamide is an organic building block, and an amidomethylating reagent.<br>References Haridas, A. K., et al.: RSC Adv., 4, 12188 (2014); Teramoto, K., et al.: Polym. J., 34, 363 (2002)<br></p>

<p>Applications α,2,4-Trichloroacetophenone is a reagent used in the synthesis of isoconazole, a potent antifungal agent.<br>References Dulcevscaia, G. et al.: Polyhed., 52, 106 (2013); Wang, Y. et al.: Bioorg. Med. Chem. Lett., 22, 5363 (2012);<br></p>

<p>Applications Cinoxate is an organic compound used as an ingredient in some types of sunscreens. Cinoxate is an ester formed from methoxycinnamic acid and 2-ethoxyethanol. Cinoxate is a slightly yellow viscous liquid that is insoluble in water, but miscible with alcohols, esters, and vegetable oils.Cinoxate protects skin against the sun by absorbing UV-A and UV-B rays.<br>References Delattre., et al.: Enzyme Microb. Tech., 41, 250 (2007); Fukuoka, T., et al.: Oleoscience, 9, 127 (2009);<br></p>

<p>Applications (2E)-Decenal is a useful starting material for organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloromandelic acid<br></p>

<p>Applications 4-Hydroxyvaleric Acid Sodium Salt is an analog of γ-Hydroxybutyrate (H833000, Ca salt) and can be used in the treatment of proteinopathies, for example Alzheimer’s disease.<br>References Maitre, M., et al. PCT Int. Appl. WO 2013024028 A1 20130221. Feb 21, 2013<br></p>

<p>Applications CHLOROFLUOROACETAMIDE (cas# 431-09-4) is a useful research chemical.<br></p>

<p>Applications 3-Chlorosalicylic Acid (cas# 1829-32-9) is a compound useful in organic synthesis.<br>References Shackelford, J.M.: J.O.C., 26, 4908 (1961)<br></p>

<p>Applications Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.<br>References Day, J. et al.: Chem. A Eur. J., 16, 2758 (2010); Sechi, M. et al.: Bioorg. Med. Chem., 17, 2925 (2009);<br></p>

<p>Applications 2-(4-CHLOROPHENYL)PROPANOIC ACID (cas# 938-95-4) is a useful research chemical.<br></p>

<p>Applications 5-Chlorosalicylic Acid, is a building block used for the manufacture of various pharmaceutical and biologically active compounds. It is used foe the synthesis of N-aryl-salicylamide derivatives as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, J., et al.: Youji Huaxue, 33, 1026 (2013); Pauk, K., et al.: Bioorg. Med. Chem., 21, 6574 (2013);<br></p>

<p>Applications 10-Hydroxybenzo[h]quinoline-7-sulfonate is used as a fluorescence method for the determination of beryllium and beryllium oxide particles.<br>References Agrawal, A., et. al.: J. ASTM Int., 8, 10 (2011); Zheng, Y., et. al.: Talanta, 85, 638 (2011)<br></p>

<p>Applications A food metabolite.<br></p>

<p>Applications A fluorescent reagent used to evaluate peptides, pharmaceutical drugs and other bioactive compounds.<br>References Rudat, B. et al.: Eur. J. Med. Chem., 46, 4457 (2011); Michail, K. et al.: Int. J. Pharm. Pharmac. Sci., 3, 180 (2011); Walsh, M. et al.: J. Fluoresc., 21, 105 (2011);<br></p>

<p>Applications α-Chloro-p-methyltoluene is a building block that has been used as a reactant for the preparation of 6-aminoquinolone derivatives as submicromolar hepatitis C virus NS5B inhibitors<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Manfroni, G., et. al.: J. Med. Chem., Ahead of Print (2013)<br></p>

<p>Applications Benzyl Glycolate was utilized as a potential moiety for the preparation of phosphonate dipeptides as potential inhibitors of VanX.<br>References Jia, C., et al.: BIoorg. Med. Chem. Lett., 22, 482 (2012);<br></p>