Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(3-Bromopropyl)-4-chlorobenzene is an expedited source of chlorine that is used in the oxidation of aromatic compounds. The chlorination of 1-(3-bromopropyl)-4-chlorobenzene occurs with a yield of about 98% and has high selectivity for the chlorination product. In a photoredox process, this compound can be used as an oxidant to produce an intermediate that can then be used in the oxidative chlorination reactions. This compound has been shown to have bioactivity and is used as a science catalyst.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-[(Cyclopropylcarbonyl)amino]acetic acid is a carboxylic acid that is used as an oral drug for the treatment of cardiac and renal diseases. It has been shown to be effective in the treatment of angiotensin-dependent hypertension and congestive heart failure. The therapeutic effects may be due to its ability to inhibit angiotensin-converting enzyme (ACE) and block the conversion of angiotensin I to angiotensin II, which causes vasoconstriction and increased blood pressure. 2-[(Cyclopropylcarbonyl)amino]acetic acid also inhibits phosphodiesterase, which may lead to improved cardiac function.

2-Methyl-5-oxopyrrolidine-2-carboxylic acid (2MOP) is a levulinic acid derivative with a carboxylic acid group on the side chain. It can be synthesized from levulinic acid, which is produced from the hydrolysis of cellulose. 2MOP is used as a plasticizer and an intermediate in the synthesis of esters such as methyl acetate and ethyl acetate. 2MOP has been found to have good compatibility with polyvinyl chloride, polystyrene, and polyolefins. This compound has been used to produce plastics that are flexible, tough, and resistant to heat degradation.

2-(4-Acetamidobenzenesulfonamido)-3-methylbutanoic acid is a disordered molecule that has an isopropanol group at the 4th carbon. The benzene ring and methyl groups are in the 2nd and 3rd positions, respectively. The orientation of the isopropyl group determines how the molecule folds. This molecule has hydrogen bonds between its N-H and C=O groups, as well as intramolecular hydrogen bonds along with coplanar dihedral angles. 2-(4-Acetamidobenzenesulfonamido)-3-methylbutanoic acid is used for research purposes to study benzene rings, methyl groups, and acetamide orientations.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one is a synthetic drug that binds to the opioid receptor and is used as an analgesic. It has been shown to have a strong affinity for opioid receptors in the central nervous system and intestine. 2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one has been found to have an uptake of 40% in the brain and intestine. This drug also has a high affinity for opioid receptors in the brain and intestinal tissue and acts as a full agonist on these sites. 2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one also has been found to be effective in treating Alzheimer's disease. This drug can be administered orally or intravenously.