Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Benzyloxy)-1H-indazole is a chemical compound that is synthesized by the reaction of 4-hydroxy-1H-indazole with benzyl bromide. This reaction proceeds through two steps: 1) diazotization and 2) aminolysis. The isoamyl acetate produced in step 1 reacts with the indazole in step 2 to produce 4-(benzyloxy)-1H-indazole. The reaction temperature for this process should be kept at or below 40°C, as it can result in a low yield of product. This chemical compound has been used as a nucleophile in various reactions and has been shown to react with nitrite ions to form an azine derivative.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-[(3-Nitrophenyl)sulfamoyl]thiophene-2-carboxylic acid is a drug that has been shown to reduce the glomerular filtration rate, metabolic rate, and body mass index in geriatric patients. 3-[(3-Nitrophenyl)sulfamoyl]thiophene-2-carboxylic acid also has an effect on the physiological function of energy metabolism and protein synthesis. The drug has been shown to inhibit prostate cancer cells by inhibiting the activity of multidrug transporter proteins such as MRP1. This drug also inhibits mesenchymal markers, which are proteins that regulate cell growth and differentiation.

Versatile small molecule scaffold

3-Amino-4-chlorophenylboronic acid is a fluorophore that can be used to study the mechanisms of biological processes. This compound has been shown to be more sensitive than other fluorophores and does not require an external light source for fluorescence. 3-Amino-4-chlorophenylboronic acid has also been used as a probe for benzene in the field of biomedicine. It is able to detect the presence of benzene with a sensitivity that is 100 times higher than that of other probes.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 3-fluoro-5-iodobenzoate is a research chemical used as a transfer catalyst. It has been used to optimize reaction conditions for letermovir, which is an antiviral drug in the class of protease inhibitors. Ethyl 3-fluoro-5-iodobenzoate has also been shown to catalyze the transfer of other molecules, such as bromoacetic acid and chloroacetic acid, from organic solvents into water. The phase transfer catalyst can be reused multiple times without loss of activity. This compound outperformed other phase transfer catalysts for this application and was found to be more selective than many others.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-N-methoxy-N-methylpyridine-4-carboxamide is a regioselective kinase inhibitor that binds to the ATP binding site of mitogen-activated protein kinases (MAPKs). It inhibits their activity by interfering with the phosphorylation of substrates, which are involved in the signaling pathway that activates MAPKs. 2-Chloro-N-methoxy-N-methylpyridine-4-carboxamide has been shown to inhibit the activity of MAPKs at concentrations as low as 1 nM, and has high specificity for some MAPKs over others. This compound also inhibits protein synthesis by preventing peptide bond formation.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-tert-Butyl-4-hydroxybenzamide is a benzonitrile that can be used as an efficient and stable catalyst for the amidation of nitriles with amines. This reaction can be carried out in the presence of boron trifluoride as a solid catalyst, or acetonitrile as a solvent. The use of this compound in organic synthesis has been shown to give high yields, especially when compared to other catalysts, such as boron trifluoride, which can often be unstable and produce toxic byproducts.

Versatile small molecule scaffold

1,7-Naphthyridine-3-carboxylic acid is an antihypertensive agent that belongs to the group of aryloxyalkyl esters. It is used in the treatment of hypertension and other cardiovascular diseases. In vitro, 1,7-naphthyridine-3-carboxylic acid has been shown to inhibit human cytomegalovirus (CMV) replication. This agent has also demonstrated antihypertensive activity in animal models of hypertension. The mechanism of action for this compound may be due to its ability to inhibit the formation of angiotensin II by blocking the conversion of angiotensin I to angiotensin II.