Building Blocks

2-Phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione (Toltrazuril) is a coccidiostatic drug that inhibits the growth of coccidia by inhibiting the synthesis of adenosine triphosphate. It has been used for chemotherapy in veterinary medicine. Toltrazuril acts as a competitive inhibitor of ATP synthase and is effective against Eimeria tenella and Eimeria acervulina.

5-Bromo-4-methoxypyrimidine is a versatile compound with a wide range of applications. It can be used as a building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and research chemicals. The benzylic nature of this compound makes it highly reactive and allows for easy functionalization. Additionally, 5-Bromo-4-methoxypyrimidine has been shown to enhance the production of biomass and promote the growth of certain microorganisms. This compound also exhibits potential therapeutic effects, such as increasing collagen synthesis and promoting the production of growth factors like TGF-β1. Whether you're a researcher or a chemist looking for a reliable source of high-quality chemicals, 5-Bromo-4-methoxypyrimidine is an essential addition to your laboratory inventory.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloroethylbenzene is an alkylating agent that reacts with a nucleophile to form a new carbon-carbon bond. It is used as a synthetic intermediate for the production of 2-chloroethyl sulfide and episulfide. 2-Chloroethylbenzene can be synthesized by the reaction of benzyl chloride with ethylene, amines, or other alkylating agents in the presence of sodium hydroxide. 2-Chloroethylbenzene can also be synthesized by the debenzylation of 2-chloroethenylbenzene with hydrochloric acid and potassium hydroxide.
Fluorination of 2-chloroethylbenzene will yield 2-chloroethyl fluoroformate, which is an important precursor to pesticides.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Hydroxy-1-cyclohexanecarboxylic acid ´-lactone is a lactone that is used as an initiator in the production of polyesters. It has also been used as a reactant for synthesizing organolithium compounds. It has been shown that 4-hydroxy-1-cyclohexanecarboxylic acid ´-lactone can be polymerized with styrene and toluene to form a copolymer. This copolymer has been studied by spectroscopy and calorimetry. The enthalpy of this reaction was determined to be -2,979 kJ/mol. The structure of 4-hydroxy-1-cyclohexanecarboxylic acid ´-lactone has been confirmed using crystallography.

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl DL-Mandelate is a chiral compound that has been shown to have an inhibitory effect on the growth of bacteria. It binds to bacterial cell surface receptors and causes lysis by creating holes in the membrane. Methyl DL-Mandelate also has high resistance against wastewater treatment; it is not removed during conventional treatment processes and can be used in the treatment of infectious diseases. The mechanism for this inhibition is unknown, but it has been hypothesized that methyl DL-Mandelate acts as an adsorbent, which blocks or inhibits the binding sites of other antibiotics or toxins.

3-Phenylacrylonitrile is an enzyme inhibitor that binds to the active site of the diphenolase enzyme, thereby inhibiting its function. The nitrile group in 3-phenylacrylonitrile is responsible for binding to the enzyme and forming a hydrogen bond with a zirconium oxide group. Hydroxyl groups on the phenyl ring also contribute to this reaction by making polar bonds with water molecules. This reaction is reversible and can be reversed by adding hydrochloric acid or by heating it at high temperatures. This reversibility provides a way to determine when 3-phenylacrylonitrile has bound to the active site of diphenolase by measuring the amount of heat released during the reaction.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation. It inhibits the enzyme cyclooxygenase, which is required for the production of prostaglandins. Naproxen has high enantioselectivity when reacting with nitriles and dinitriles because it acts as a diacid or amid acid in these reactions. This means that naproxen preferentially reacts with the 2-hydroxy group of an acyl chloride or ester, forming an amide or amidine respectively. It also has an ability to inhibit bacterial strains such as those from Streptococcus pyogenes and Staphylococcus aureus. Naproxen may act by substituting for the carboxylic acid groups of the bacterial cell wall, where it can form a covalent bond with glutamic acid residues on the cell wall surface.