Building Blocks

<p>2,3,4,5-Tetrahydro-1-benzoxepin-3-one is an acrylamide derivative that has been shown to undergo ring cleavage under certain conditions. The cleavage of the benzene ring leads to the formation of two aromatic rings and a carboxylic acid.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>1,2,3,4-Tetrahydropyrido[3,4-b]pyrazine is an organic solvent that has been shown to be a good catalyst for the dimerization of isocyanates. It is used as a basic additive in resins and coatings. 1,2,3,4-Tetrahydropyrido[3,4-b]pyrazine is soluble in most solvents and can be used as a diluent of other solvents. This chemical has been shown to have good thermal stability and low volatility.</p>

<p>6-Chloro-5-formyl-1,3-dimethyluracil is a cyclized compound that is formed from the reaction between a vinyl group and sulfilimine. It has been shown to be a precursor for the synthesis of uracil derivatives by photolysis. 6-Chloro-5-formyl-1,3-dimethyluracil is also an intermediate in the synthesis of analogues of uracil and cytosine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-1-methoxypyrrolidin-2-one is a halogenated alkynyl compound that is used as an anti-inflammatory agent. It is a phenylcyclizing agent that reacts with an alkoxy group to form an alkyne and a cyclic ether. The cyclic ether then undergoes nucleophilic attack by an adjacent hydroxyl group, resulting in the formation of an oxetane ring. 3-Bromo-1-methoxypyrrolidin-2-one has been shown to have anti-inflammatory activities in mice and rats by inhibiting the production of inflammatory cytokines such as TNF, IL1β, and IL6.</p>

3-Bromo-1-ethylpyrrolidin-2-one is an enantiomeric, immobilized lipase that is selective for the hydrolysis of cephalosporins. Unlike other immobilized lipases, this enzyme does not require a solvent or detergent to solubilize the substrate and allow it to react with the enzyme. The immobilization of 3-bromo-1-ethylpyrrolidin-2-one onto silica gel allows for the enantioselective synthesis of cephalosporins. This process is chemoenzymatic and is carried out without organic solvents, which increases its safety and environmental friendliness.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>4,5-Diodoveratrole is a ligand that binds to tylophorine. It has been shown to be an interlinked molecule in electrochemical methods and can be detected by voltammetry. 4,5-Diodoveratrole has been used as a fluorescent sensor for methyl groups and is also able to cross-couple with methoxy groups. This molecule also forms functional groups on the devices of electrochemical biosensors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-[3-(Trifluoromethyl)-1,2-oxazol-5-yl]acetamide is a fluorescence resonance energy transfer inhibitor that has been shown to be effective against the papillary muscle in rats. This drug has also been shown to inhibit the production of growth factors and cell proliferation in prostate cancer cells. N-[3-(Trifluoromethyl)-1,2-oxazol-5-yl]acetamide inhibits the enzyme kinase activity of protein tyrosine kinases, which are responsible for cell proliferation and differentiation. This drug is also an organometallic compound with low light fluorescence properties. It has been used as a radiation sensitizer to increase the effectiveness of radiation treatments for cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>t-Butyl 2-iodobenzoate is a reagent that can be used to access cyclopentenes. The reaction begins with the lithiation of an alkoxycarbonyl group and the subsequent attachment of an electrophilic cyclopentene. The reaction is completed by adding a tertiary amine, which causes carbopalladation of the alkyl lithium intermediate, forming a new carbon-carbon bond. Cyclopentenes can also be accessed by intramolecular reactions using a palladium catalyst and alkoxycarbonyl groups as substrates. Camptothecin moieties are often functionalized with t-butyl 2-iodobenzoate in order to access camptothecin analogs.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold