Building Blocks

<p>Versatile small molecule scaffold</p>

2H-4λ4-1,4-Oxathiin-4-imine 4-oxide is a heterocyclic compound composed of an aromatic nucleus, a five membered ring with one hydroxyl group and a six membered ring with one nitro group. The heterocycle has two unsubstituted nitro groups and a sulfoximine group. 2H-4λ4-1,4-Oxathiin-4-imine 4-oxide can be synthesized by reacting the amino compound 2H-3λ3-(3'-aminopropionitrile) with nitrous acid or hydrochloric acid. This reaction produces 2HNCH2CO2H which is then reacted with carbon dioxide to form the desired product. 2HNCH2CO2H + CO2 → 2HNCH(CO2)OH + H+

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>6-(2-Thienyl)-2-pyridinecarboxaldehyde is an experimental compound that has not been tested in humans. It is a liquid at room temperature, with a boiling point of 230°C. 6-(2-Thienyl)-2-pyridinecarboxaldehyde can be injected intravenously, intramuscularly, or subcutaneously. The compound has shown promise in preliminary experiments as a chemotherapeutic agent against cancer and chronic viral infections.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

(4-Cyclohexylphenyl)methanol is a potent glutamic acid analog that has been shown to inhibit prostate-specific antigen (PSA) in the human prostate cancer cell line LNCaP. This compound has been synthesized as a lead for optimizing and optimizing PSA inhibitors. It has also been shown to inhibit membrane antigens, which may be due to substitutions at the phenyl ring. The results of this study suggest that (4-cyclohexylphenyl)methanol is a novel inhibitor of PSA, which may have therapeutic potential for the treatment of prostate cancer.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chloro-1-methylpyrrolidin-2-one is a homologous compound that can be synthesized from physostigmine and lactams. It is a nucleophilic reagent that can act as an efficient chemoselective agent for the synthesis of six-membered ring alkaloids. 3CMP has been used in many organic chemistry reactions and has shown high yield in most cases. This compound is also used to prepare tricyclic compounds, including the antihypertensive drug amlodipine.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2-Phenylmethylidenecyclobutan-1-one is a cyclic ketone that can be synthesised by thermal rearrangement of the enolate anion of 2,2-dimethylcyclopropane carboxylic acid. The thermally induced isomerisation is reversible and the equilibrium lies in favour of the starting material. This compound has an optical isomerism, with one form (enantiomer) being chiral and the other not. The suprafacial enolate anion reacts with electrophiles at the carbonyl carbon to form a 1,2-didehydrobenzene or a 1,4-didehydrobenzene. <br>The compound also undergoes a series of stereochemical changes when it reacts with nucleophiles such as methanol or water, forming dimers in which two molecules are linked by an oxygen bridge.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Benzoxazole-4-carboxylic acid is a metabolite of benzoxazinone and has been shown to have antibiotic properties. It was found to inhibit the growth of bacteria by binding to their ribosomes and inhibiting protein synthesis. This compound also inhibits acetylcholinesterase activity in tissues and skeletal muscle, which may be due to its ability to bind with phosphatidic acid and phospholipases. 1,3-Benzoxazole-4-carboxylic acid has been shown to accumulate in the esophagus in rats after oral administration. In one study, this compound was found to reduce the number of colonies grown on plates containing strains of E. coli and S. aureus.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold