Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Heptyl carbamate is a cholinergic antagonist of the blood disorders. It has been shown to inhibit hydroxy and hiv infection. In vitro assays have shown that heptyl carbamate inhibits the synthesis of fatty acid, thereby reducing cholesterol levels and inhibiting the production of insulin resistance in cells. Heptyl carbamate also binds to the same site on acetylcholinesterase as donepezil, which blocks the breakdown of acetylcholine and leads to an accumulation of this neurotransmitter in nerve cells. This increased concentration of acetylcholine in nerve cells can lead to a reduced incidence of Alzheimer's disease-related symptoms.

1-Chloro-4-methylpentan-2-one is a chemical compound that inhibits bacterial growth by binding to the 50S ribosomal subunit. It has been shown to inhibit methicillin resistance in Staphylococcus aureus, and also has an antibacterial effect on other gram-negative bacteria. 1-Chloro-4-methylpentan-2-one is active against both gram positive and gram negative organisms, but the spectrum of activity is limited because it is not active against acid fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. 1CMTD has been shown to be stable in its crystalline form and can be administered orally.

2-(Propan-2-yl)thiophene is a cyclopropylamine that reacts with ruthenium to form a ruthenium complex. This complex is thermodynamically stable, and can absorb light in the visible region of the spectrum. The addition of ligands such as phenanthroline or isopropyl groups enhances its photophysical properties, and can be used to catalyze alkylation reactions. 2-(Propan-2-yl)thiophene has an electron-withdrawing group on the phenyl ring, which makes it susceptible to nucleophilic attack by electrophiles. This property is useful for kinetic studies of alkylation reactions, because it allows for observation of the rate at which an alkylating agent approaches a given substrate.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Chloro-1-ethyl-1H-pyrazole is an alkylhydrazine. It can be prepared by reacting 5-chloro-1,2-dihydro-3H-[1,2,4]triazole with ethyl chloride and sodium hydroxide in water. The yield of 5-chloro-1,2-dihydro-[3H]-pyrazole can be increased by using a dimethylhydrazine as the starting material. The reaction of 5-chloro-[3H]-pyrazole with benzoyl chloride in acetic acid yields the corresponding alkylhydrazone. The reaction of 5-(chloromethyl)-1,2-(dihydro)pyrazole with potassium bromide yields the corresponding dimethylhydrazine. Hydrazines and hydrazones are both nitrogen containing compounds that react with organic compounds in a similar way to form

Versatile small molecule scaffold

Versatile small molecule scaffold

(+/-)-4-Benzylazetidin-2-one is an enantiomer of the β-lactam antibiotic azetidinone. It has been synthesized by chemoenzymatic methods and is a racemic mixture of two enantiomers. (+/-)-4-Benzylazetidin-2-one is a lactam with a carboxylic acid substituent in the lactam ring. The chlorides are removed from the molecule by ammonolysis, which produces the amide. This amide reacts with an alkyl group, such as methyl chloride, to produce the lactam ring. The synthesis of (+/-)-4-Benzylazetidin-2-one can be catalyzed by either acidic or basic catalysts. These reactions are typically carried out in organic solvents and require heat and/or pressure to proceed at a reasonable rate. (+/-)-4 -Benzylazetid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Nitro-2-(piperidine-1-yl)pyridine is a product that is formed by the nucleophilic addition of nitric acid to 1,3-diketones. It has been used in the synthesis of phenyl and isoxazole derivatives. The reaction was rationalized using amines as nucleophiles, which attack the electrophilic carbon atom in the ketone. This product has also been shown to be an effective nucleophile for attacking other molecules, such as azides and nitrates. In the Australian outback, 5-Nitro-2-(piperidine-1-yl)pyridine can be found in soils and plants.

Versatile small molecule scaffold

1-Bromopentan-2-ol is an additive that is used in lubricating preparations, as well as a solvent in spectroscopy. It has been shown to have antimicrobial properties against fungi and bacteria. 1-Bromopentan-2-ol's antimicrobial effects are due to its ability to inhibit the growth of bacteria by binding to amine groups on proteins and preventing the formation of new cell walls. 1-Bromopentan-2-ol also has the ability to react with formaldehyde, generating formaldehyde gas which inhibits microbial growth.

Versatile small molecule scaffold

Versatile small molecule scaffold