Building Blocks

Versatile small molecule scaffold

4-(Trichloromethyl)pyridine is an organic compound that can be used as a pesticide. It is the main active ingredient in chloropicrin, which is used primarily for agricultural purposes to help protect crops from insect damage. 4-(Trichloromethyl)pyridine has been shown to have toxic effects on animals, including humans, and may cause adverse health effects such as headaches, nausea, vomiting and dizziness. The chemical reacts with hydrogen chloride in the presence of an organic solvent to form the chlorinated derivative of 4-chloropyridinol. The reactivity of 4-(trichloromethyl)pyridine towards nucleophilic inorganic bases has also been studied and it was found that it reacts with potassium hydroxide at room temperature to form a 1:1 mixture of 4-chloropyridinol and potassium chloride.

1H-Isoindol-3-amine is a coordination complex with a palladium atom coordinated to three active methylene ligands. It is used as an intermediate in the synthesis of organic compounds. 1H-Isoindol-3-amine can be synthesized by the reaction of sodium hydrogen with hydroxybenzoic acid, followed by the Suzuki coupling reaction with copper chloride and an aryl chloride. The coordination chemistry between 1H-Isoindol-3-amine and palladium has been studied using viscosity measurements and X-ray diffraction data. The coordination complexes are usually based on aryl chlorides, which are electron rich, electron deficient, or electrophilic. The reaction mechanism for 1H-Isoindol-3-amine has been recorded.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 5-amino-2-furoate is a nitrofuran that is used as a reagent in the synthesis of other compounds. It has been shown to be metabolized by acetylation, hydrazine, and reduction. Methyl 5-amino-2-furoate can also act as an inhibitor of xanthine oxidase and xanthine dehydrogenase. The compound has been shown to inhibit the production of xanthine and aminofuran in an incubated system containing these enzymes. Spectrometry analysis showed that methyl 5-amino-2-furoate was reduced to form methyl 2,5-dihydroxybenzoate during incubation with xanthine oxidase and xanthine dehydrogenase.

Versatile small molecule scaffold

1,1-Dimethylguanidine hydrochloride is an oxadiazole derivative that is used in the treatment of bacterial infections. It is a competitive inhibitor of bacterial leukocyte-mediated killing of bacteria and inhibits the growth of staphylococcal and staphylococcus aureus isolates. In vitro, 1,1-dimethylguanidine hydrochloride has been shown to inhibit the growth of gram-positive bacteria by binding to their cell wall. This drug also has a kinetic effect on leukocytes, which may be due to its ability to inhibit the release of reactive oxygen species from these cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(3-Bromofuran-2-yl)ethan-1-one is a monoterpenoid that belongs to the family of indole alkaloids. It has been isolated from natural sources and can be synthesized in the laboratory. Indole alkaloids are biologically active compounds with a variety of uses. 1-(3-Bromofuran-2-yl)ethan-1-one has shown biological activities, including antiinflammatory and antimicrobial properties.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(1H-Tetrazol-5-yl)phenol is a coordination compound that belongs to the class of nitrates. It has magnetic properties and can be found in a number of architectures, such as frameworks and solid-state structures. 3-(1H-Tetrazol-5-yl)phenol can be synthesized in the form of single crystals using a combination of a nitrate salt, ammonium chloride, and sulfuric acid. 3-(1H-Tetrazol-5-yl)phenol has been used as an analytical tool for elemental analysis. This compound's luminescence properties have been studied extensively, with the use of different spectra such as UV/Vis absorption spectroscopy or emission spectroscopy.

Versatile small molecule scaffold

Versatile small molecule scaffold

(S)-Willardiine is a sodium salt that belongs to the group of pharmacological agents. It is used as a chemical intermediate, but has been found to have some biological properties. In vivo studies in rats have shown that (S)-willardiine inhibits the release of glutamate and GABA in the cortex and hippocampus, which may be related to its ability to increase locomotor activity. Disulfide bond formation is required for biological activity, which has been observed using human serum. The structure of (S)-willardiine was determined by x-ray crystallography at 1.5 Å resolution, revealing that it contains an asymmetric unit consisting of one molecule each of (S)-willardiine and sodium chloride.