Building Blocks

Versatile small molecule scaffold

2,6-Diethylphenylisothiocyanate is an aliphatic anesthetic agent that binds to the acceptor site of the ligand-gated ion channels. It has a hydrophobic nature and can be used for research as a potential drug candidate for a variety of protein targets. This compound also has the ability to alter conformations of proteins such as apoferritin, which may lead to new insights into how these proteins function.

2,6-Dichloro-4-phenylpyridine is a chemosensor that can be used to detect the presence of aromatic compounds. It has a modular structure consisting of an emission domain and a substrate binding domain. The fluorophore is reversibly bound to the substrate binding domain, which means that it can be detached from the substrate when the desired molecule is detected. This sensor has been shown to have high selectivity for aromatic molecules in both water and organic solvents. 2,6-Dichloro-4-phenylpyridine has also been studied structurally and found to react with a number of other chemical entities such as thiocyanate ion, nitrobenzene, and nitrophenol.

N-Cyclopentylacetamide is a reactive alkylating agent that is used in the synthesis of organic chemicals. It reacts with chlorine to form chloroform, and with acetonitrile to form acetanilide. N-Cyclopentylacetamide also reacts electrochemically with fission products such as uranium to form uranium hexafluoride. The reaction of N-Cyclopentylacetamide with bromides yields a spectrum of cyclopentyl bromides. This compound can be used for the synthesis of pharmaceuticals and other chemical compounds.

Versatile small molecule scaffold

7-Methyl-2-phenylimidazo[1,2-a]pyridine is a fluorescent compound that has been used as a shift reagent. It is colorless and stable in air and light. The fluorescence of 7-methyl-2-phenylimidazo[1,2-a]pyridine is excited at wavelengths of 315 nm and 380 nm with an emission maximum at 460 nm. This compound can be used to study the conformational changes of proteins and nucleic acids by monitoring the change in fluorescence properties.

Versatile small molecule scaffold

Versatile small molecule scaffold

2,4,6-Trimethoxy-1,3,5-triazine is a trimethyl triazine that is used as a polymerization initiator in the production of polyester. It has been shown to be reactive with monocarboxylic acids and ester compounds. The molecular weight of 2,4,6-trimethoxy-1,3,5-triazine increases with increasing temperature. This chemical has also been shown to be an efficient crosslinking agent for both hydrated and linear filaments.

Versatile small molecule scaffold

4-(Methoxymethoxy)aniline is an antibacterial agent that belongs to the group of fluoroquinolones. It has been shown to have a broad spectrum of activity against gram-negative bacteria and is also active against some gram-positive bacteria. 4-(Methoxymethoxy)aniline inhibits the synthesis of bacterial proteins by binding to ribosomes and inhibiting the activity of phosphatases, which are enzymes that catalyze reactions in the cell. This drug can be synthesized from 4-chloroaniline, which is converted into 4-methoxyaniline through a sequence of reactions involving benzyl esters and azide. The final product is then converted into 4-(methoxymethoxy)aniline using a phosphatase enzyme.

Versatile small molecule scaffold

Cinnoline-4-thiol is an inhibitor of the protein PD-L1, which is a targetable tumor antigen. It blocks the interaction between PD-L1 and its receptor CTLA-4, thereby inhibiting the activation of T cells and reducing their proliferation. This molecule has been shown to have anti-tumor activity in vitro and in vivo. Cinnoline-4-thiol has been shown to inhibit tumor growth by suppressing cancer cell proliferation. It also induces apoptosis, which leads to cancer cell death by activating caspases. Cinnoline-4-thiol has been shown to be active against many different types of cancers, including breast cancer, colorectal cancer, non-small cell lung cancer, ovarian carcinoma, pancreatic cancer and prostate cancer.

Versatile small molecule scaffold

4-Aminostilbene is a fluorescent stilbene derivative that is used as a synthetic estrogen. It has been shown to possess anti-inflammatory properties and inhibit the production of reactive oxygen species in target tissues. 4-Aminostilbene also possesses anti-cancer properties and has been shown to be effective against Pseudomonas aeruginosa. The mechanism of action for this compound is thought to be via its ability to react with amines, forming diazonium salts in an organic solution.

5-Methoxy-2,3-dimethyl-1H-indole is an indole that is used as a drug. It has anti-inflammatory activity and belongs to the class of intermolecular drugs. It works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. 5-Methoxy-2,3-dimethyl-1H-indole can be found as crystals and has a crystal structure that contains a five membered ring with one double bond and one methyl group on each side of the ring.

Versatile small molecule scaffold

2,4-Dibromo-6-nitroaniline is a nitro compound that has been used in the production of dyes. It is also used as a component in the synthesis of other organic compounds. 2,4-Dibromo-6-nitroaniline can be produced by electrolysis of an acid solution containing radical cations and benzene. The radical cations are formed by proton transfer from the acid to the benzene, followed by electron transfer from benzene to the electrode. This process results in the formation of nitro groups on the benzene ring, which undergoes oxidation to form 2,4-dibromo-6-nitroaniline. The cyclic voltammetry shows that this process occurs via two pathways: one with a fast rate and one with a slow rate. The mechanism for this reaction is not yet known.

2-Phenyl-1,3,4-oxadiazole is a 2-phenyloxazole with an oxygen atom at the 1 position. It is a white crystalline solid that is soluble in water and has antibacterial properties. This chemical can be used as a catalyst for the synthesis of organic compounds. 2-Phenyl-1,3,4-oxadiazole reacts with nitro groups to form oxime derivatives and has been shown to inhibit the growth of fungi such as Candida albicans and Aspergillus niger. 2-Phenyl-1,3,4-oxadiazole can also be used as an antifungal agent against Trichophyton rubrum.
2-Phenyl-1,3,4-oxadiazole may be synthesized by reacting phenol with acetone in the presence of nitric acid or sulfuric acid. The structural formula for this compound is

1-Benzothiophene 1,1-dioxide is a potential drug target for the treatment of cryptococcus neoformans. It inhibits bacterial growth by inhibiting the transport properties of the bacteria, which in turn leads to cell death. This compound has been shown to have potent antitumor activity and may be activated through x-ray diffraction data analysis. The compound also has fluorescence properties and hydrogen bond formation, which may aid in its chemical structure.