Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Hydroxymethyl)cyclohexan-1-ol is a potassium salt that is used as an intermediate for the synthesis of other chemicals. It has been shown to be a strong inhibitor of the enzyme acetylcholinesterase in vitro, which leads to increased levels of acetylcholine and neurotransmission. The compound has also been shown to inhibit the growth of bacteria by inhibiting protein synthesis through an unknown mechanism. 2-(Hydroxymethyl)cyclohexan-1-ol is isolated from a variety of sources, including wood tar, coal tar, and petroleum.
2-(Hydroxymethyl)cyclohexan-1-ol can be synthesized by solvolysis with potassium hydroxide or tetrafluoroborate followed by acetolysis with acetic anhydride.
Potassium acetate can also be used to synthesize 2-(hydroxymethyl)-cyclohexan-1-

Versatile small molecule scaffold

1,2,5,6,7,8-Hexahydroquinoxalin-2-one is a stimulant that has been shown to be effective for the prophylaxis and/or treatment of diabetes. It is also a prophylactic agent for the prevention of pyrazinone. This drug has been shown to stimulate insulin secretion from pancreatic beta cells in vitro. 1,2,5,6,7,8-Hexahydroquinoxalin-2-one stimulates the release of insulin by stimulating exocytosis and inhibiting vesicle fusion in response to glucose. It can also inhibit or stimulate the release of insulin in response to other stimuli such as amino acids and fatty acids.

Versatile small molecule scaffold

Tributyl(methoxymethyl)stannane is a synthetic organo-tin compound that has antifungal, antiviral, and antibacterial properties. It is also used in the treatment of idiopathic pulmonary fibrosis, hepatitis, cirrhosis, heart disease, and scleroderma. Tributyl(methoxymethyl)stannane inhibits the synthesis of proteins by binding to the 30S ribosomal subunit through a number of mechanisms. It has been shown to inhibit the growth of many fungi including those that cause athlete's foot and ringworm. Tributyl(methoxymethyl)stannane also shows some promise as an anti-inflammatory agent.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Prop-1-en-2-yl)cyclohexane is a chemical compound that belongs to the group of organometallic compounds. It is an imine with a cyclohexane ring. Prop-1-en-2-yl)cyclohexane has been shown to be effective in the treatment of aminotransferases, which are enzymes that break down amino acids. This drug has also been shown to have optical properties and can be used as a dietary supplement or pharmacological treatment.

1-[2-(Propan-2-yl)phenyl]ethan-1-one is a chemical compound that belongs to the group of esters. It is an emulsifier for pharmaceutical, cosmetic and food products. 1-[2-(Propan-2-yl)phenyl]ethan-1-one has been used in the production of micronized particles that are not complexed with polyvinyl acetate or other polymeric matrices. This product can be used as a reaction product in the synthesis of cyclodextrin and also as an efficient method for the production of dry powder form.

Versatile small molecule scaffold

1-Benzothiophene-5-carbonitrile is a heterocyclic compound that is formed by condensation of ethyl azidoacetate with indole under catalysis. It can be used in the synthesis of heterocycles. The yield of 1-benzothiophene-5-carbonitrile is about 56%.

Versatile small molecule scaffold

Versatile small molecule scaffold

Phenylthiohydantoin-glycine is a drug used for the treatment of muscle diseases such as myasthenia gravis, Lambert-Eaton syndrome, and post-polio syndrome. It inhibits the production of acetylcholine at neuromuscular junctions by interfering with the synthesis of proteins that are critical for signal transmission from nerve cells to muscles. Phenylthiohydantoin-glycine is a small molecule consisting of two amino acids, phenylthiohydantoin and glycine. The drug binds to lysine residues on proteins using its hydroxyl group and trifluoroacetic acid moiety. This binding prevents the formation of an active enzyme that catalyzes the conversion of choline into acetylcholine at neuromuscular junctions.

3-(3-Nitrophenyl)-1-phenylurea is a fluorinated compound that inhibits the growth of plants by inhibiting photosynthesis. It is used as an insecticide and fungicide. 3-(3-Nitrophenyl)-1-phenylurea also has been shown to have some antiviral properties.

3-(2-Methoxyphenyl)-1-(4-methylphenyl)-1H-pyrazol-5-amine is a high purity ligand for many receptors, including GABA and NMDA receptors. It has been shown to activate both ion channels and receptor proteins in the central nervous system, which may be due to its ability to inhibit chloride ion flux through GABA receptors. 3-(2-Methoxyphenyl)-1-(4-methylphenyl)-1H-pyrazol-5-amine also binds to the NMDA receptor and is an inhibitor of protein interactions.