Building Blocks

4-Amino-5-chloro-2-methoxybenzamide is a secondary amine that is synthesized from the reaction of diethylaminoethyl chloride and chlorinating agents. 4-Amino-5-chloro-2-methoxybenzamide has low potency in vitro and is not active in vivo. It does not have an effect on 5HT4 receptors, but it has been shown to be a potent agonist for 5HT4 receptors in vitro. The synthesis of 4-amino-5-chloro-2 methoxybenzamide can be done by reacting diethylaminoethyl chloride with chlorinating agents. This synthesis reaction produces the desired product with low potency, which may be due to the presence of other products such as quaternary ammonium salts and chloride.

Versatile small molecule scaffold

Versatile small molecule scaffold

Benzyl (cyano)methylamine is an anti-hypertensive agent that belongs to the group of propionyl chloride. It is a benzene derivative with a methyl group attached to one of the rings. Benzyl (cyano)methylamine can be used as an intermediate in the synthesis of other compounds, such as cyclohexanone, phenoxyacetic acid, and acetophenone.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Bromo-2,3-dihydro-4H-chromen-4-one is a borohydride reduction and molecular modeling study of an analog of the natural product. The 14α-demethylase enzyme catalyzes the conversion of 3β,14α-dihydroxyandrostane to 3β,14β-dihydroxyandrostane. This enzyme has stereoselective activity in the synthesis of androgens from progesterone. The hydrogen bond interactions between the active site residues and solvent molecules are important for the enzymatic activity.