Building Blocks

3-Chlorophenethyl bromide is a linker that binds to viral proteins in the dimer interface and inhibits viral replication. It has been shown to be an inhibitor of HIV-1 reverse transcriptase and human immunodeficiency virus type 1 protease. 3-Chlorophenethyl bromide has also been found to inhibit the binding of HIV-1 integrase, which leads to inhibition of HIV-1 DNA integration into host cell chromosomes. 3-Chlorophenethyl bromide can be used for the treatment of AIDS and is being investigated for its use as a prophylactic agent for HIV infection.

4-Amino-2-isopropylphenol is a phenolic compound that is used in the synthesis of esters. It reacts with carboxylic acids to form an acylation product, which is selective for hydroxy groups. 4-Amino-2-isopropylphenol can be used as a solvent for phenolic compounds such as resorcinols and hydroquinones. This reagent also selectively reacts with organic solvents preferentially to hydroxy groups on the same molecule. The regioselective reaction of 4-amino-2-isopropylphenol is due to its steric hindrance by the substituent on the isopropyl group.

2',4'-Dimethoxyacetoacetanilide is a disubstituted dicarbonyl compound that is synthesized by acetoxylation of 2,4-dimethoxybenzaldehyde. The equilibrium between the two forms can be shifted to favor one form through the addition of reagents, such as dimethylformamide or dicarbonyl compounds. The oxidation of 2',4'-dimethoxyacetoacetanilide with hydrogen peroxide yields 2,4-dihydroxydiphenylmethane, which can undergo hydrolysis with hydrochloric acid to yield phenol.

(4-Methoxy-pyridin-2-yl)-methanol is a nucleophile that can be used in the preparation of phosphorothioates and triphosphates. It is also used to synthesize oligonucleotides, which are biomolecules used to probe the structure of DNA. This compound has been shown to have high yields and is exothermic, making it a good candidate for catalysis. The chemical properties of (4-Methoxy-pyridin-2-yl)-methanol make it an excellent nucleophile with a strong affinity for phosphorous, which makes it useful in the synthesis of phosphorothioates and triphosphates.

Versatile small molecule scaffold

4-Chloro-3-iodo-quinoline is a ligand that has been shown to have agonistic activity with the immune system. It has been demonstrated to be an adjuvant in vaccines, and has been shown to be effective against furan, chlorine, and azide. 4-Chloro-3-iodo-quinoline is structurally related to 3-(trifluoromethyl)quinoline, which is a pharmacological agent used for the treatment of rheumatoid arthritis. The pharmacological effects of 4-chloro-3-iodo quinoline may be due to its ability to bind with toll like receptor.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-(4-Chlorobenzyl)thiazol-2-amine is an arylation reagent that can be used for the synthesis of various heterocyclic compounds. 5-(4-Chlorobenzyl)thiazol-2-amine reacts with acrolein, alkyl chlorides, and acid chlorides to produce substituted thiazoles. This compound is also useful in the synthesis of phthalic anhydride, and it can act as a substitute for thiourea in reactions with unsaturated carboxylic acids.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Tert-butyl 6-chloronicotinate is a chemical compound that is used as a reagent in organic synthesis. It is prepared by reacting tert-butyl nitrite with chloroform. This transformation can be achieved efficiently within 10 minutes and the yield of the reaction can be increased by using azide instead of ammonium chloride. The tert-butyl group on the compound provides an efficient method for amine displacement, which is useful for heteroaryl substitution. The reaction has been shown to work well with amines such as pyridine, quinoline, and indole.