Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(3-Nitrophenyl)acrylaldehyde is an organic compound that belongs to the class of aldehydes. It is used in the synthesis of halogenated compounds, such as dibromohexane, and in organic chemistry as a building block for the preparation of hydrophobic compounds. 3-(3-Nitrophenyl)acrylaldehyde reacts with benzene in an aldol condensation reaction to form 2,4-dinitrobenzaldehyde. This reaction may be catalyzed by acid or base. The efficiency of this reaction is increased when it is carried out at lower temperatures and higher pressures. The ring-opening reaction of 3-(3-nitrophenyl)acrylaldehyde with methanal also proceeds efficiently at lower temperatures and higher pressures.

Methyl 5-methyl-2-oxocyclohexane-1-carboxylate is a racemic compound with the chemical formula CH3(CH2)4CO2. The individual enantiomers are known as D and L methyl 5-methyl-2-oxocyclohexane-1-carboxylate. This compound is a sesquiterpenoid and has been found to inhibit the growth of certain bacteria, fungi, and parasites. The biological activity of this compound is due to its ability to interfere with protein synthesis by binding to the active site of enzymes that require a carboxyl group for their function. Methyl 5-methyl-2-oxocyclohexane-1-carboxylate can be found in nature as a mixture of two enantiomers, but it can also be synthesized in a racemic form.

2-Oxopyridin-1(2H)-yl)acetic acid is a colorless, crystalline solid that can be used as a reagent for organic synthesis. It has been shown to inhibit the growth of C. parapsilosis and T. tetracosane at low concentrations. 2-Oxopyridin-1(2H)-yl)acetic acid may have an inhibitory effect on the enzyme dehydrogenase, which catalyzes the conversion of hexadecanoic acid to hexadecenoic acid during lipid metabolism and is required for cell survival. This compound has also been shown to be effective against M. tuberculosis and M. avium complex, but not against other bacteria such as B. subtilis or S. aureus.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Methyl-2-picolylmethylamine is a dimeric compound that contains two picolyl methyl groups per molecule. It can be prepared by the reaction of picolinic acid with an appropriate amine, such as methylamine. 6-Methyl-2-picolylmethylamine reacts with dioxane to form a yellow solid, which is a potentiometric indicator. The potentiometric titration of 6-methyl-2-picolylmethylamine has shown that it has a pK value of 7.3 and a color change at pH 7.8.

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one is a potent inhibitor of the enzyme c-glycosylase. This compound has been used in pharmaceutical preparations and as a feedstock in organic syntheses. It is used to produce the anti-inflammatory drug piroxicam, which inhibits the action of cyclooxygenase and blocks the synthesis of prostaglandins. 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one also has been shown to inhibit crystallization of the bovine liver enzyme phosphatidylcholine:cholesterol acyltransferase (PCAT). The inhibition was found to be competitive with respect to PCAT substrate and was not due to inhibition of PCAT by 1,2,4-triazolo[4,3-a]pyridin-3(