Building Blocks

Versatile small molecule scaffold

4-Methyl-1,3-thiazolidine-2-thione is a selective disulfide reductase with metal halide and cycloaddition activity. It catalyzes the reaction of alkali metal with carbon disulfide to form aziridine. The reaction proceeds through two steps: in the first step, alkali metal is reduced by carbon disulfide to form an alkyl radical; in the second step, the alkyl radical reacts with carbon disulfide to form aziridine. 4-Methyl-1,3-thiazolidine-2-thione has been shown to be an efficient catalyst for this reaction and can also catalyze cycloadditions between urethane and aziridine.

2-(Methylthio)pyrimidine-4,5,6-triamine is a centrosymmetric molecule with a molecular weight of 184.07 g/mol. It forms hydrogen bonds with water and interacts with other molecules. 2-(Methylthio)pyrimidine-4,5,6-triamine has been shown to form stacking interactions in crystal structures due to the presence of hydrogen bonds. Hydrogen bonds are formed between molecules when the partial positive charge on one molecule is attracted to the partial negative charge on another molecule. The attraction between these molecules can be facilitated by the presence of water molecules and is most prevalent in substances that have a high degree of hydrogen bonding potential, such as sugars and proteins.
2-(Methylthio)pyrimidine-4,5,6-triamine has also been shown to form hydrogen bonds with organic compounds such as methanol and ethanol.

5-(1H-Indol-3-yl)pentanoic acid is a potent and selective serotonin reuptake inhibitor (SSRI). It has been shown to have a high affinity for the serotonin transporter (SERT), with a binding constant of about 5 nM. The compound has been shown to be bifunctional, which means it can inhibit both serotonin and dopamine reuptake. 5-(1H-Indol-3-yl)pentanoic acid is also orally active, so it can be used in vivo as well as in vitro. This drug has been found to have pharmacokinetic properties that are similar to those of fluoxetine and citalopram. Pharmacophore modeling studies have revealed that this drug binds to the SERT by creating hydrogen bonds with amino acids such as serine, threonine, tyrosine and tryptophan.

4-Chloro-2-methyl-6-nitroquinoline is an antimicrobial agent that exhibits a broad spectrum of activity against both gram-positive and gram-negative bacteria. It also has antifungal properties. 4-Chloro-2-methyl-6-nitroquinoline inhibits the growth of bacteria by binding to DNA and RNA in the bacterial cell, thereby inhibiting transcription and replication. It also inhibits the synthesis of proteins in fungi, which may be due to its ability to bind to fungal ribosomes and inhibit protein synthesis.

Phenothiazine 5-oxide is a potent inhibitor of oxidative reactions that can be used to oxidize phenoxazine. Phenothiazine 5-oxide has been shown to inhibit the oxidation of phenoxazine by sodium hydroxide solution in an electrochemical study. This vibrational, irreversible oxidation reaction was introduced by the introduction of sodium salts, which are potent inhibitors of oxidative reactions. Phenothiazine 5-oxide has been shown to have potent inhibitory activity against cervical cancer cells and shows promise as a chemotherapeutic agent for this type of cancer.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold