Réactifs synthétiques

<p>Applications N-Methyl-2-(4-nitrophenyl)ethanamine Hydrochloride is used as a reactant in the preparation of small molecule CDC25 phosphatases inhibitors.<br>References Contour-Galcera, Marie-Odile, et al.: Bioorg. &amp; Med. Chem. Let., 14(23), 5809-5812 (2004)<br></p>

<p>Applications Antipsychotic used in the treatment of schizophrenia.<br>References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),<br></p>

<p>Applications Labelled selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease.<br>References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001), Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001), Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002), Rabe, K.F., et al.: Lancet, 366, 563 (2005),<br></p>

<p>Applications 3-Carboxyphenylboronic Acid is used in phenylboronic acid-decorated gelatin nanoparticles for enhanced tumor targeting and penetration.<br>References Wang, X., et al.: Nanotechnology, 27, 385101 (2016); Wang, X., et al.: Eur. J. Pharm. Biopharm., 113, 168 (2017)<br></p>

<p>Applications Indigopurpurin is a purple 3,2-bisindole derivative and was shown to exhibit inhibitory allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. A possible glycogen synthase kinase-3 (GSK-3) inhibitor the active component of a traditional Congolese antiepilepsy treatment.<br>References Kim, M.H., et al.: J. Ethnopharmacol., 145, 214 (2013); Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Hsieh, W.L., et al.: J. Dermatol. Sci., 67, 140 (2012); Chem. and Eng. News page 6 Nov. 10 (2018)<br></p>

<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>

<p>Applications (1R)-(+)-α-Pinene is used in hydroboration reactions and the reduction of ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, H. et al.: J. Org. Chem., 50, 1384 (1985);<br></p>

<p>Applications Sodium Chlorite is used as a bleaching agent for cotton textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shenai, V.A., Pai, S.M.: Textile Dyer Printer, 3, 153 (1969)<br></p>

<p>Stability Light Sensitive<br>Applications Farnesone is s useful building block for organic synthesis<br></p>

<p>Applications Anti-bacterial agent.<br>References Banfi, E., et al.: J. Chemotherapy, 5(3), 164 (1993),<br></p>

<p>Applications Ivacaftor is used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Tetrakis(triphenylphosphine)palladium(0) is widely used as a catalyst for palladium-catalyzed coupling reactions.<br>References Malatesta. L., et al.: J. Chem. Soc., 1186 (1957);<br></p>

<p>Applications 3-Acetopropanol is a substrate for alcohol dehydrogenase and is an intermediate in the synthesis of Didesethyl Chloroquine (D440960), a metabolite of Chloroquine.<br>References Ohkuma, S., et al.: J. Cell. Biol., 90, 656 (1981); Araki, N., et al.: J. Biol. Chem., 267, 10211 (1992); Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003); Traebert, M., et al.: Eur. J. Pharmacol., 484, 41 (2004)<br></p>

<p>Applications Myxochelin A is a potent inhibitor of human 5-lipoxygenase (5-LO). Studies show that Myxochelin A is a natural product that may possess potent antitumor activity at non-cytotoxic concentrations.<br>References Schieferdecker, S., et al.: Tetrahedron Lett., 57, 1359 (2016); Korp, J., et al.: ChemBioChem., 16, 2445 (2015); Schieferdecker, S., et al.: J. Nat. Prod., 78, 335 (2015)<br></p>

<p>Applications Amiloride Monohydrochloride Dihydrate is used as an inhibitor of 11β-hydroxysteroid dehydrogenases (11β-HSD) for treating alcohol use disorders.<br>References Sanna, P. et al.: PCT Int. Appl. (2017)<br></p>

<p>Stability Hygroscopic<br>Applications Tris(3-sulfophenyl)phosphine Trisodium Salt is a reagent used in organic synthesis such as benzothiazole-based cycloplatinated chromophores.<br>References Lalinde, E. et al.: Chem. A Eur. J., 24. 2440 (2018);<br></p>

<p>Applications Sclareol is used in biological studies as it has anti-inflammatory activity in both lipopolysaccharide-stimulated macophages and λ-carrageenan-induced paw edema model.<br>References Huang, G., et al.: J. Nat. Prod., 75, 54 (2012); Weninger, S., et al.: Nat. Med 7, 527 (2001)<br></p>

<p>Applications A silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocking with trimethylsiloxy units. Commonly used in skin and hair products. Approximate M.W. 2000.<br>References Disapio, A. et al.: Int. J. Cosmet. Sci. 10, 75(1988)<br></p>

<p>Applications Iron(III) meso-Tetraphenylporphine Chloride along with Cameroonian smectite clay has been employed to modify glassy carbon electrodes used in the simultaneous quantification of ascorbic acid, uric acid and nitrite.<br>References Kemmegne-Mbouguen, J.C., et al.: Sens Actuators B Chem, 212, 464-471 (2015);<br></p>

<p>Stability Hygroscopic<br>Applications Mn(III) meso-Tetra (N-Methyl-4-pyridyl) Porphine Pentachloride is a synthetic, Manganese (III) porphyrin.<br></p>

<p>Applications Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).<br>References Greve, J., et al.: Int. J. Dermatol., 50, 1294 (2011); Cole, S.W., et al.: Ann. Pharmacother., 47, 49 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Ampicillin. Orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.<br>References Ivashkiv, E., et al.: Anal. Profiles Drug Subs., 2, 1 (1973), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987), Sill, M. L., et al.: Antimicrob. Agents Chemother., 52, 1551 (2008),<br></p>

<p>Applications A receptor adenine derivative binding membrane brain animal cell line.<br>References Camaioni, E., et al.: Bioorg. Med. Chem., 6, 523 (1998), Kelly, M., et al.: Br. J. Pharmacol., 125, 979 (1998), Redzic, Z., et al.: Brain Res., 888, 66 (2001), Levy, D., et al.: J. Med. Chem., 46, 2177 (2003),<br></p>

<p>Applications Ginkgoneolic Acid is a natural mutagenic, carcinogenic and genotoxic agent. An isolate from Ginkgo Biloba leaf, used in traditional medicines treating inflammation and cell proliferation.<br>References He, J. et al.: Fol. Microbiol., 58, 147 (2013); Li, R. et al.: J. Nat. Prod., 77, 571 (2014);<br></p>

<p>Applications (S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol, is a diarylprolinol silyl ether organocatalyst. It is able to catalyze a variety of bond-forming reactions such as C-C, C-N, C-O, C-S, and C-Hal in high yields and excellent levels of enantiocontrol.<br>References Jensen KL, et al. Accounts of Chemical Research 45(2), 248-264, (2011);<br></p>

<p>Stability Moisture Sensitive<br>Applications n-Undecanoyl Chloride is an analog of Heptanoyl Chloride (H281235), which is used in the synthesis of novel class of 2-Aminopyrimidines as CDK1 and CDK2 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Samanta, R., et al.: Org. Lett., 14, 5518 (2012); Sabbah, M., et al.: Bioorg. Med. Chem., 20, 4727 (2012)<br></p>

<p>Applications A multikinase inhibitor once used for cancer treatment.<br>References Ulisse, S., et al.: J. Endocrinol., 204, 135 (2010), McDermott, U., et al.: Cancer Res., 70, 1625 (2010), Donato, N., et al.: Biochem., Pharmacol., 79, 688 (2010),<br></p>

<p>Applications (R)-2-Hydroxybutanoic acid (cas# 20016-85-7) is a useful research chemical.<br></p>

<p>Applications 4-Pyridylthioacetic Acid (cas# 10351-19-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Adipic Acid is primarily used in the synthesis of nylon. It has been used as a reagent in the solid-state polymerization of nylon analogs.<br>References Kim, Y. et al.: Ind. Eng. Chem. Res., 51, 15801 (2012)<br></p>

<p>Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.<br>References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),<br></p>

<p>Applications Sofalcone is a substituted chalcone with anti-ulcer activity.<br>References Matsuo, Y., et al.: Arzneim. Forsch., 33, 242 (1983), Suwa, T., et al.: Jpn. J. Pharmacol., 35, 47 (1984),<br></p>

<p>Applications Sodium selenite is used in reducing carcinogenesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3,3-Diphenylpropylamine is a metabolite of Prenylamine (P712800). 3,3-Diphenylpropylamine showed antiextensor effects as well as neuroexcitatory effects and antagonized barbital-induced loss of the righting reflex.<br>References Hornke, I. et al.: Arzneim.-Forsch., 20, 791 (1970); Remberg, G. et al.: Biomed. Mass Spec., 4, 197 (1977); Helke, C. et al.: Eur. J. Pharmacol., 48, 231 (1978);<br></p>

<p>Applications Bepotastine is a histamine H1 receptor antagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).<br>References Kaminuma, O. et al.: Biol. Pharm. Bull., 21, 411 (1998); Kitaba, S. et al.: J. Allergy, No pp. given (2008); Lyseng-Williamson, K.A., Drugs, 70, 1579 (2010);<br></p>

<p>Applications Phosphoric Acid Monosodium Salt Dihydrate, is a reagent widely used in the preparation of biological buffers. It is highly hygroscopic and can be used in many applications including in gel electrophoresis.<br>References Salaun, F.: "Influence of mineral environment on the buffering capacity of casein micelles", "Milchwissenschaft", 62(1):3<br></p>

<p>Applications Sodium Phosphate Dibasic Dihydrate is a treatment of Ischemic stroke with aptamers targeting toll-like receptor 4 (TLR-4).<br>References Perez Rodriguez, D., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications Tivozanib is known as an oral VEGF receptor tyrosine kinase inhibitor, exhibiting antitumor effects towards renal cell carcinoma.. Tivozanib suppresses angiogenesis by selectively inhibiting against vascular endothelial growth factor. Potent VEGFR inhibitor.<br>References Nosov, D.A., et al.: J. Clinical. Oncol., 30, 1678 (2012); Pal, S.K., et al., Molec. Cancer. Thr, 11, 526 (2012);<br></p>

<p>Stability Unstable in Solution, Air Sensitive<br>Applications An antirheumatic agent.<br>References Masutani, K., et al.: Clin. Nephrol., 70, 464 (2008), Kobata, Y., et al.: Modern Rheumatol., 19, 629 (2009), Oki, K., et al.: Inflam. Res., 58, 571 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications 3-Carboxamidobenzoic acid<br></p>

<p>Applications Occurs in most varieties of Cinchona bark. It is stereoisomeric with Cinchonine. Antimalarial.<br>References Litchfield, J., et al.: J. Pharm. Exp. Ther., 96, 99 (1949), Trager, W., et al.: Science, 193, 673 (1976), Panisko, D., et al.: Drugs, 39, 160 (1990), Karle, J., et al.: Antimicrob. Agents Chemother., 36, 1538 (1992),<br></p>

<p>Applications Larotrectinib Sulfate is a potent and selective oral ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).<br>References Anon.: Cancer Discovery, 6, 4 (2016); Passiglia, F., et al.: Expert Opin. Investig. Drugs, 25, 385 (2016)<br></p>

<p>Applications (S)-2-Bromopropionic Acid is an intermediate in the synthesis of structural analogs of the antimitotic tripeptides hemiasterlins as antitumor agents.<br>References Gamble, W., et al.: Bioorg. Med. Chem., 7, 1611 (1999),<br></p>

<p>Applications Sodium Hydroxide, also known as lye, is a very common chemical reagent. It is a strong base used in industrial chemical applications. Used in the textile, food and medicinal industries. Its ability to digest tissues allows for analysis of various effects of pharmaceutical agents in rodent tissue.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McMillan, A. et al.: Ind. Eng. Chem., 10, 488 (1918); Nymul, K. et al.: J. Chem. Eng., 24, 35 (2006); Gilbert, D. et al.: Antimicrob. Agents Chemother., 30, 361 (1986);<br></p>

<p>Applications KU 55933 is an ATM kinase inhibitor, which provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism, ultimately inhibiting calpain and cathepsin D.<br>References Chwastek, J.; Jantas, D.; Lason, W.: Int. J. Biochem. Cell Biol., 87, 38 (2017)<br></p>

<p>Applications Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity<br>References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);<br></p>

<p>Applications A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Chiu, T.A., et al.: J. Pharmacol. Exp. Ther., 252, 711 (1990), McIntyre, M., et al.: Pharmacol. Ther., 74, 181 (1997), Pitt, B., et al.: Lancet, 355, 1582 (2000);<br></p>

<p>Applications Copper(II) Sulfate Pentahydrate is a chemical reagent used as a fungicide. Used to control fungus growth on various fruits and the spread of aquatic plants primarily.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michaud, J. et al.: J. Insect. Sci., 3, 16 (2003);<br></p>

<p>Impurity Cefuroxime Sodium EP Impurity E<br>Applications Desethyl Acetate (E)-Cefuroxime Axetil (Cefuroxime Sodium EP Impurity E) is a product from the photoisomerization of Cefuroxime Axetil (C248065), which is s widely used to treat respiratory tract infections. Antibacterial.<br>References Fabre, H., et. al.: J. Pharm. Sci., 83, 553 (1994); Nguyen, N., et al.: Pharm. Res., 8, 893 (1991); Stoeckel, K., et al.: Antimicrob. Agents Chemother., 42, 2602 (1998); Scott, L., et al.: Drugs, 61, 1455 (2001); Bulitta, J. B., et al.: Antimicrob. Agents Chemother., 53, 3462 (2009)<br></p>

<p>Applications Girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.<br>References Mirzaei, H., et al.: J. Chrom. A, 1134, 122 (2007); Kanofsky, J.R., et al.: Photochem. Photobiol., 73, 349 (2001);<br></p>

<p>Applications Toxic to some wild and domestic birds and mice. Molluscicidal activity<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References De Abreu, F. et al.; Bioorg. Med. Chem. 9, 659 (2001); Schafer, E.W. et al.; Arch. Environ. Con. Tox. 14, 111 (1985); Schafer, E.W. et al.; Arch. Environ. Con. Tox. 12, 355 (1983)<br></p>

<p>Stability Moisture Sensitive<br>Applications Used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor.<br>References Sussman, J., et al.: Science, 253, 872 (1991), Mallender, W., et al.: J. Biol. Chem 1999, 274, 8491,<br></p>

<p>Applications (S)-(+)-Propane-1,2-diol is a general reagent used in organic synthesis. (S)-(+)-Propane-1,2-diol is used in the synthesis of anti-tuberculosis agents inspired by BTZ043 for MDR resistant strains.<br>References Tiwari, R. et al.: ACS Med. Chem. Lett., 5, 587 (2014); Tiwari, R. et al.: J. Am. Chem. Soc., 135, 3539 (2013);<br></p>

<p>Applications Cobalt(II) chloride hexahydrate (cas# 7791-13-1) is a useful research chemical.<br></p>

<p>Applications Ketanserin Tartrate is used in nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis for preventing a variety of diseases ranging from cancer to ischemic injury.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gohil, V. M., et al.: Nat. Biotechnol, 28, 249 (2010)<br></p>

<p>Stability Store in freezer<br>Applications Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine.<br>References Yoon, C., et al.: Mol. Cancer Res., 7, 361 (2009), Giussani, P., et al.: J. Biol. Chem., 284, 5088 (2009), Chen-Quay, S., et al.: J. Pharm. Sci., 98, 606 (2009), Satoh, Y., et al.: J. Biochem., 145, 31 (2009),<br></p>

<p>Applications Gonadorelin Acetate is used in various agricultural and biological studies. It was used in the study of ovulation synchronization in dairy cows.<br>References Pursley, J., et al.: Theriogenology, 44, 915 (1995).<br></p>

<p>Applications 9-(N-Methylaminomethyl)anthracene is a reactant that has been used in the synthesis of anthracene-oxyquinoline dyad as a fluorescent indicator for Hg(II).<br>References Praveen, L., et. al.: Tetrahedron Lett., 53, 3951 (2012)<br></p>

<p>Impurity Atomoxetine EP Impurity E<br>Applications (S)-(+)-Mandelic Acid (Atomoxetine EP Impurity E) is an antiseptic (urinary).<br>References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007), Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009),<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt is a cytotoxic metabolite of Cyclophosphamide (C988580).<br>References Driven, H.A.A.M. et al.: Chem. BIol. Inter., 93, 185 (1994); Fenselau, C. et al.: Xenobiotica, 22, 1207 (1992);<br></p>

<p>Applications Sodium methylsulfinate can be used to synthesize cyclooxygenase-2 inhibitors.<br>References Khanna, I. K., et al: J. Med. Chem. 40, 1619 (1997); Penning, T. D., et al.: J. Med. Chem 40, 1347 (1997)<br></p>

<p>Applications Ho2O3 (cas# 12055-62-8) is a useful research chemical.<br></p>

<p>Applications (1R,2R)-1,2-Diphenyl-1,2-ethanediamine (cas# 35132-20-8) is a compound useful in organic synthesis.<br></p>

<p>Applications The active metabolite of Cilazapril. An ACE inhibitor. Antihypertensive.<br>References Natoff, I.L., et al.: J. Cardiovasc. Pharmacol., 7, 569 (1985), Szucs, T., et al.: Drugs, 41, Suppl.1, 18 (1991), Pordy, R.C., et al.: Cardiology, 86, 41 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications Fasudil Monohydrochloride Salt is a selective ROCK inhibitor.<br>References Kanazawa, I., et al.: Endocr. J., 57, 415-421 (2010); Ding, J., et al.: J. Neurochem., 114, 1619-1629 (2010); Li, Y., et al.: Med. Sci. Monit., 16, BR112-BR118 (2010); Fujimura, M., et al.: Toxicol. Appl. Pharmacol., 250, 1-9 (2011);<br></p>

<p>Applications Rochelle’s Salt is a common chemical precipitant from in x-ray crystallography as well as a useful ingredient in Biuret’s Reagent, a useful tool in the measurement of protein concentration.<br>References Mulki, S. et al.: J. Ind. Soc. Periodont., 17, 42 (2013); Tam, A. et al.: Bioorg. Med. Chem., 17, 1055 (2009);<br></p>

<p>Applications AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>

<p>Applications Reagent used in the preparation of carbonic anhydrase inhibitors.<br></p>

<p>Applications Iron(III) Chloride Hexahydrate is used as a reagent in the synthesis of Iron Trisglycinate (I775475); a compound used in biological studies to evaluate the dietary iron absorption from whole corn meal in humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bovell-Benjamin, A. C., et al.: Am. J. Clin. Nutr., 71, 1563 (2000)<br></p>

<p>Applications Labelled Vincristine. An antitumor alkaloid isolated from Vinca rosea Linn. An antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burns, J.H., et al.: Anal. Profiles Drug Subs., 1, 463 (1972), Owellen, D., et al.: J. Med. Chem., 15, 894 (1972),<br></p>

<p>Applications MK8722 is a systemic, direct pan-activator of AMP-activated protein kinase.<br>References Feng, Danqing, et al.: ACS Med. Chem. Let., 9(1), 39-44 (2018);Myers, Robert W., et al.: Science, 357(6350), 507-511 (2017)<br></p>

<p>Applications Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>

<p>Applications Abietic Acid is the primary component of resin acid found commonly in rosin. Abietic Acid exhibited potent testosterone 5α-reductase inhibitory activity in vitro.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roh, S.-S. et al.: J. Health Sci., 56, 451 (2010); Harris, G.C. et al.: Org. Synth., 32, 1 (1963);<br></p>

<p>Applications Methoxyacetyl chloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications S-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Romano, K.P. et al.: Chem. Res. Toxicol., 20, 832 (2007); Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948);<br></p>

<p>Applications Mirtazapine is an α2-Adrenergic blocker; analogue of Mianserin. Antidepressant.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Lead(IV) acetate is most commonly used in synthetic chemistry as an oxidizing agent, and is a versatile precursor for lead-containing compounds. Lead(IV) acetate is a toxic substance to humans, and is also known to induce oxidative damage and hyperlipidemia in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Newairy, A., et al.: Food Chem. Toxicol., 47, 813 (2009); Rahman, S. &amp; Sultana, S.: Chem.-Biol. Int., 160, 61 (2006); Yadav, R.: Synlett, 2012, 1262 (2012)<br></p>

<p>Applications 4-Hydroxyquinolineis a hydroxylated quinoline derivative with antimicrobial activity. 4-Hydroxyquinoline showed growth-inhibitory effects against intestinal bacteria. 4-Hydroxyquinoline act as sacrificial scavengers of the photogenerated oxygen species and has been shown to prevent the photodegradation of riboflavin.<br>References Kim, Y.-M. et al.: Food Sci. Biotechnol., 15, 817 (2006); Criado, S. et al.: J. Photochem. Photobiol. B Biol., 71, 19 (2003):<br></p>

<p>Applications Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications D-Menthol is used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Ikaheimo, I., et al.: J. Antimicrob. Chemother., 46, 287 (2000), Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>