Réactifs synthétiques

<p>Applications Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.<br>References Stehlin, J.S., et al.: Int. J. Oncol., 14, 821 (1999), Verschraegen, C.F., et al.: Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs, 1, 184 (1999),<br></p>

<p>Stability Store in Freezer<br>Applications Benzyl 3-Amino-3-deoxy-α-D-mannopyranoside Hydrochloride can be used for preparation of swainsonine analogs as immunostimulants.<br>References Dime, D., et al.: PCT Int. Appl., 74 pp. (1993),<br></p>

<p>Applications N-Methyl-1,3-propanediamine is used as a reagent in the lipase-catalyzed synthesis of novel linear polyamidoamine oligomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Monsalve, L.N., et al.: Polymer, 51, 2998 (2010)<br></p>

<p>Applications 12-CROWN-4 (cas# 294-93-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Dimethylaminobenzylamine is used in the preparation of N-benzyl and N-aryl furylpurines as inhibitors of mycobacteria for potential use as antituberculosis agents.<br>References Bakkestuen, A., et al.: Bioorg. Med. Chem. Lett., 10, 1207 (2000), Gundersen, L., et al.: Med. Chem., 45, 1383 (2002),<br></p>

<p>Applications 6-Bromo-2H-1,4-benzoxazin-3(4H)-one is used in the synthesis of substituted benzoxazinones; selective 5-HT6 antagonists used for treating central nervous system diseases and gastrointestinal tract disorders.<br></p>

<p>Applications 1-Chloro-3-iodopropane is used as reagent in the synthesis of several organic compounds including that of (-)-Terengganensine A which is a complex heptacyclic monoterpene indole alkaloid. Also used in the synthesis of A-366 which is a potent inhibitor of histone methyltransferase G9a.<br>References Piemontesi, C., et al.: Angew. Chem. Int. Edit., 55, 6556 (2016); Sweis, R., et al.: ACS Med. Chem. Lett., 5, 205 (2014);<br></p>

<p>Applications Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein.<br>References Firestone, A., et al.: Nature, 484, 125 (2012)<br></p>

<p>Applications 1,1-Cyclopropanedicarboxylic Acid, is an inhibitor of 1-aminocyclopropane-1-carboxylic Acid oxidase in Lycopersicum esculentum (Tomato plant). It can also be used as a building block for the synthesis of a series of cyclopropanecarboxamides, having antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Petritis, K., et al.: Phytochemical Analy., 14, 347 (2003); Liu, X. H., et al.: Euro. J. Med. , 44, 2782 (2009);<br></p>

<p>Applications 2-Bromoacetic Acid Phenylmethyl Ester is used in the synthesis of somatostatin analogues with tumor-targeting properties . Also used in the synthesis of inhibitors of phospholipase A2, indolizine and indene derivatives.<br>References Heppeler, A. et al.: Chem. A. Eur. J., 5, 1974 (1999); Hagishita, S. et al.: J. Med. Chem., 39, 3636 (1996);<br></p>

<p>Applications Ammonium Hexafluorophosphate is commonly available form of the hexafluorophosphate anion, inert and hence a suitable counterion. It is a useful synthetic intermediate. It can be used to prepare organometallic diphenols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Powell, C., et al.: J. Am. Chem. Soc., 125, 602 (2003); Macchioni, A., et al.: Organometallics, 18, 3061 (1999)<br></p>

<p>Applications Copper oxychloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,3-Dibromopropene is used in preparation of Quaternary Ammonium Salt derivatives for use as Trimethylamine production inhibitors.Also, used in preparation of Boron containing compounds as Phosphodiesterase PDE4 inhibitors.<br>References Nudel, K., et al.:PCT Int. Appl., (2020); Strohbach, Joseph W., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications Diethyl D-(-)-Tartrate is used as a chiral reagent in a host of chemical reactions, suhc as marin toxin and antitumor agent phorboxazole A, or asymmetric syntheses of S,S-dialkyl-substituted sulfoximines.<br>References Pandey, A. et al.: Synthesis, 23, 3827 (2011); Kuntiyong, P. et al.: Org. Biomol. Chem., 10, 7884 (2012);<br></p>

<p>Applications N4-Benzoylcytosine is a reactant in the synthesis of 1',2'-cyclopentyl nucleosides as potential antiviral agents.<br>References Dang, Q., et. al.: Tetrahedron Lett., 55, 5092 (2014)<br></p>

<p>Applications Drug used in the treatment of Parkinson’s disease and psychosis.<br>References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010), Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010),<br></p>

<p>Applications Piperonylamine is a metabolite of dopamine analogs.<br>References Goodwin, B.L., et al.: Xenobiotica, 24, 129 (1994),<br></p>

<p>Stability Light Sensitive<br>Applications Enprostil is a synthetic analogue of prostaglandin E2 and was found to be effective in the treatment of patients with duodenal or gastric ulcers.<br>References Goa, K.L., et al.: Drugs., 34, 539 (1987); Higuchi, K., et al.: Inflammopharmacol., 15, 18 (2006); Murata, H., et al.: Hepato-Gastroenterol., 52, 1925 (2005);<br></p>

<p>Applications Tideglusib is used in the treatment of brain atrophy, and movement disorder issues.<br>References Hoeglinger, G. et al.: Movement DIs., 29, 579 (2014); Tolosa, E. et al.: Movement Dis., 29, 570 (2014);<br></p>

<p>Applications 2,3-Dichloropyrazine is a substrate used for an efficient synthesis of aloisine (A575450), a potent cyclin-dependent kinase.<br>References Chekmarev, D.S., et al.: Tetrahedron., 62, 9919 (2006);<br></p>

<p>Applications GI 254023X is an ADAM10 metaloproteinase inhibitor.<br>References Hoettecke, N., et. al.: Neurodegeneration Diseases, 7, 232 (2010)<br></p>

<p>Applications 11-Bromo-1-undecene acts as a reagent used in the chemoenzymatic synthesis of macrolide antibiotics for the treatment of common bacteria infection.<br>References Chatterjee, S., et al.: RSC Adv., 4, 42697 (2014)<br></p>

<p>Applications trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.<br>References Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012); Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)<br></p>

<p>Applications [4,​4'-​Bis(tert-butyl)​-​2,​2'-​bipyridine]​bis[3,​5-​difluoro-​2-​[5-​(trifluoromethyl)​-​2-​pyridinyl]​phenyl]​iridium(III) hexafluorophosphate is commonly used as a catalyst in the synthesis of various compounds such as saturated N-​heterocycles from aldehydes, fosmidomycin analogue, and many more.<br>References Jindakun, C., et al.: Org. Lett. 20, 2071-75 (2018); Guo, T., et al.: Adv. Synth. Catal., 360, 1352-57 (2018); Abbas, S.Y., et al.: Org. Lett., 20, 868-71 (2018)<br></p>

<p>Applications [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene] Dichloro(o-isopropoxyphenylmethylene)ruthenium is a cross-metathesis catalyst used for installation of S-allylcysteine in proteins for enabling olefin metathesis on proteins.<br>References Lin, Y.A., et al.: J. Am. Chem. Soc., 132, 16805 (2010); Chalker, J.M., et al.: Chem. Comm., no vol., 3714 (2009)<br></p>

<p>Applications Chlorotripyrrolidinophosphonium Hexafluorophosphate acts as a peptide coupling reagent or condensing agent for phosphinate ester formation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prasad, K. et al.: Int. J. Pharm. Sci. Rev. Res., 8, 108 (2011); Winqvist, A. et al.: Eur. J. Org. Chem. 10, 1705 (2008);<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N-Dimethylphosphoramidodichloridate functions as a reagent used in the inhibition of acetylcholinestrase and butyryl cholinestrase by nerve agent surrogates. Also, the are used as reagents in the synthesis and in the antitumor activity of nonsymmetric phosphoric acid triamides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meek, E. C., et al.: Toxicol. Sci., 126, 525 (2012); Kosykhova, L., et al.: Pharm. Chem., 34, 525 (2000)<br></p>

<p>Applications Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Potent PI3K/mTOR Dual Inhibitor.<br>References Konstantinidou, G., et al.: Cancer Res., 69, 7644 (2009), Frederick, R., et al.: Bioorg. Med. Chem. Lett., 19, 5842 (2009), Pollizzi, K., et al.: Mol. Cancer, 8 (2009),<br></p>

<p>Applications Rhenium Carbonyl, is used as a catalyst and in material science. iIt is also a key starting material used for the synthesis of other rhenium carbonyl complexes. It plays an important role in metathesis, reforming and hydrogenation reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kremlev, K. V., et al.: J. Surf. Ingestig.-X-Ray Synchro. 2015, 9 (4), 694-698.; Di, X., et al.: Catal. Sci. Technol. 2015, 5 (4), 2441-2448.;<br></p>

<p>Applications Trimethylboroxin (50% Solution in THF) is used in a diverse array of areas, including as a polymerization additive. Trimethylboroxin is also used in the preparation of CBS catalysts for asymmetric reductions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gilmore, N., et al.: Tetrahedron Asy., 14, 2115 (2003); Najera, C., et al.: Adv. Synth. Catal., 346, 1798 (2004);<br></p>

<p>Applications N-DesBoc Docetaxel is an impurity in the synthesis of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications A reagent used in the synthesis of Pitavastatin.<br>References Mukaiyama, H., et al.: Chem. Pharm. Bull., 55, 881 (2007), Paruch, K., et al.: Bioorg. Med. Chem. Lett., 17, 6220 (2007),<br></p>

<p>Applications 3-Bromopropionic Acid is used as a reagent in the synthesis of nitrogen containing diselenides which exhibit antioxidant activity. Also used as a reagent in the synthesis of indolin-2-one-based multi-targeted receptor tyrosine kinase inhibitors as potential anticancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nascimento, V., et al.: Eur. J. Med. Chem., 87, 131 (2014); Zhang, L., et al.: Eur. J. Med. Chem., 82, 139 (2014)<br></p>

<p>Applications N-Phenylglycinonitrile is a useful building block used in the preparation of purine derivatives with ability to inhibit protein kinases by competitive displacement of ATP.<br>References Laufer, S., et al.: J. Med. Chem.: 48, 710 (2005);<br></p>

<p>Applications Bis(pinacolato)diboron is used as a condensation agent in the preparation poly(arylene)s. Bis(pinacolato)diboron is an organoboranate with potential use as matrix metallo-proteinase (MMP-2) inhibitor.<br>References Ali, H.A. et al.: Arch. Pharm., 337, 183 (2004); Izumi, A. et al.: Chem. Lett., 7, 728 (2000);<br></p>

<p>Applications ABT 925 Fumerate is a dopamine D3 receptor antagonist that is used in the treatment of acute schizophrenia (1).<br>References (1) Redden, L., et al.: J. Clin. Psychopharmacol, 31, 221 (2011)<br></p>

<p>Applications A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.<br>References Berman, D., et al.: Science, 297, 1559 (2002), Varjosalo, M., et al.: Cell, 133, 537 (2008), Theunissen, J., et al.: Cancer Res., 69, 6007 (2009),<br></p>

<p>Applications 2,3-Diaminopyridine is used as a reagent in the synthesis of novel imidazopyridine derivatives which can exhibit cytotoxic activity against MCF-7 human breast adenocarcinoma cell line. 2,3-Diaminopyridine is also used in the preparation of non-camptothecin topoisomerase I inhibitors which exhibit antitumor activity.<br>References Puskullu, M.O., et al.: Chem. Heterocyc. Compd., 51, 723 (2015); Zhang, C., et al.: Bioorg. Med. Chem. Lett., 25, 4693 (2015)<br></p>

<p>Applications N-(4-Methoxybenzyl)-N-methylamine is used in the synthetic preparation of many types of compounds, including the synthesis of trifluoromethyl-sulfonimidamides from sulfinamides as well as the preparation of piperazinylquinazoline amine compounds as toll-like receptor 9 signaling antagonists for treatment of immune disorders.<br>References Richards-Taylor, C.S.; et al.: J. Org. Chem, 82, 9898 (2017); Talukdar, A.; et al.: PCT Int. Appl. 89pp. Patent 2017 CODEN:PIXXD2<br></p>

<p>Applications 7-Amino-alpha-tetralone<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled Acetic Acid is used for analysis and profiling of biological samples resolved through NMR spectroscopy. It helps with the labelling of RNA for high resolution NMR.<br>References Cahoreau, E. et al.: Anal. Bio., 427, 158 (2012);<br></p>

<p>Applications Lanthanum(III) Trifluoromethanesulfonate is a catalyst that is used for the trans-esterification of Jatropha curcas L. oil with methanol and higher alcohols. Studies on rats and mice showed that Lanthanum(III) Trifluoromethanesulfonate is a moderately hazardous substance causing slight irritation of the skin and that the maximum permitted concentration in the workplace is 2.0 mg/m3.<br>References Daniel, L., et al.: J. Am. Oil Chem. Soc., 91, 325 (2014); Zhurba, O.M., et al.: Toksikologicheskii Vestnik, no vol., 20 (2005)<br></p>

<p>Applications 2-Methoxybenzoyl Chloride is an aromatic acyl chloride derived from anisic acid. 2-Methoxybenzoyl Chloride is used in the preparation of a wide range of compounds such as anti-virals, anti-bacterials and antitumor agents.<br>References Li, Z. et al.: Chem. Biol. Drug Des., 79, 1018 (2012); Liu, W. et al.: Huax. Tong., 74, 665 (2011); Sousa, E. et al.: Eur. J. Med. Chem., 44, 3830 (2009);<br></p>

<p>Applications 1-Bromo-3,5-difluorobenzene is used in the synthesis of selective antagonists of GluN2C/GluN2D is used in the synthesis of COX-2 inhibitors as anti-inflammatory agents and anti-cancer agents.<br>References Khanna, I. et al.: J. Med. Chem., 40, 1634 (1997); Pommery, N. et al.: J. Med. Chem., 47, 6195 (2004);<br></p>

<p>Applications Silver Carbonate is used in organic synthesis in the Koenigs-knorr glycosylation reaction. It is also known as Fetizon's reagent acting as an oxidising agent on celite forming lactones form diols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fetizon, M., et al.: J. Chem. Soc. Chem. Comm., 19, 1118 (1969);<br></p>

<p>Applications Intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Applications VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.<br>References Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010); Lebois, et al.: ACS Chem. Neurosci., 1, 104 (2010),<br></p>

<p>Applications Benzyl Isocyanate is a general reagent used in the synthesis of complex bisindolylmethanes. Also used in the preparation of urea derivatives of thiazol-2-ethylamines for their anti-trypanosomal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patrick, D. et al.: Bioorg. Med. Chem., 24, 2451 (2016);<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);<br></p>

<p>Applications Niobium Pentachloride is a reagent used in the synthesis of mixed chloro-aryloxide compounds and dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ilin, A. et al.: J. Alloy. Comp., 748, 543 (2018); Yuan, L. et al.: Inorg. Chem., 57, 4226 (2018);<br></p>

<p>Applications Ammonium Bicarbonate is a useful reagent in the synthesis of double-shelled CoMn2O5 hollow microcubes used as anode material for lithium-ion batteries.<br>References Zhou, L., et al.: Adv. Mater., 24, 745 (2012);<br></p>

<p>Applications Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase.<br>References Umezawa, H., et al.: J. Antib., 29, 97 (1976); Poloz, Y., et al.: Eukaryotic Cell, 11, 545 (2012);<br></p>

<p>Applications LE 300 is a potent and selective dopamine receptor antagonist.<br>References Hefnawy, M., et al.: Luminescence, 31, 63-66 (2016)<br></p>

<p>Applications (S)-(−)-α,4-Dimethylbenzylamine was used in the study of heterogeneous Raney nickel and cobalt catalysts for racemization and dynamic kinetic resolution of amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parvulescu, A., et al.: Adv. Synth. Catal., 350, 113 (2008);<br></p>

<p>Applications Diethylenetriamine-pentaacetic acid calcium trisodium salt<br></p>

<p>Applications 2,6-Di-tert-butyl-4-nitrophenol is a potentially powerful uncoupler of ATP-generating oxidative phosphorylation that has been reported to be a contaminant in submarines and indoor spaces, causing a number of objects to turn yellow (even human skin).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ball, J., et al.: Science, 272, 101 (1996); Rivera-Nevares, J., et al.: Env. Toxicol. Chem., 14, 251 (1995); Rothweiler, H., et al.: Atm. Env. B: Urb. Atm., 25, 231 (1991)<br></p>

<p>Applications Guanadine thiocyanate is a strong protein denaturant. It is used as a chaotropic agent for the isolation of intact RNA during the process of cell lysis. It shows strong irreversible inhibition on enveloped viruses. It is a key chemical used to isolate the virus’ genetic material, or RNA so that it can be tested.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Dacomitinib is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.<br>References Williams, J. et al.: PLoS., 9, e98557 (2014); Peters, S. et al.: Canc. Treatment Rev., 40, 917 (2014);<br></p>

<p>Applications Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles.<br>References Harrington, M. et al.: Eur. J. Clin. Nutr., 65, 20 (2011); Takasawa, K. et al.: Nutrients, 7, 103 (2015);<br></p>

<p>Applications LY 2874455 is a pan-FGFR inhibitor which remain the focus of research for use in lung and bladder cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gozgit, J. et al.: Mol. Cancer Ther., 11, 690 (2012); Zhao, G. et al.: Mol. Cancer Ther., 10, 2200 (2011);<br></p>

<p>Applications Tetrapropylammonium bromide (cas# 1941-30-6) is a useful research chemical.<br></p>

<p>Applications Tetramethylammonium Hydroxide is used to prepare a new family of silicate/aluminosilicate mesoporous molecular sieves.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Beck, J., et al.: J. Am. Chem. Soc., 114, 10834 (1992).<br></p>

<p>Applications A peripheral µ-opioid receptor antagonist. Gastroprokinetic.<br>References Zimmerman, D.M., et al.: J. Med. Chem., 37, 2262 (1994), Liu, S.S., et al.: Clin. Pharmacol. Ther., 68, 66 (2000), Taguchi, A., et al.: N. Engl. J. Med., 345, 935 (2001),<br></p>

<p>Applications GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.<br>References Jeffrey J.W., et al.: Clinical. Cancer. Rsch., 10, 1078 (2012); Murray, J.M., et al.: J. Medn. Chem., 55, 7686 (2012);<br></p>

<p>Applications (±)-Paraconic Acid is used as a reagent in the synthesis of methylenecarboxybutyrolactones which have antibacterial activity.<br>References Tonari, K., et al.: J. Oleo Sci., 51, 259 (2002)<br></p>