Réactifs synthétiques

Applications Iron(III) Chloride is commonly employed as a Lewis acid for catalysing reactions such as chlorination of aromatic compounds and Friedel-Crafts reaction of aromatics. In industrial application, iron(III) chloride is used in sewage treatment and drinking water production. It is also used as a leaching agent in chloride hydrometallurgy.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cox, D., et al.: J. Am. Chem. Soc., 110, 8085 (1988); Tauxe-Wuersch, A., et al.: Water Res., 39, 1761 (2005); Trebouet, D., et al.: Water Res., 35, 2935 (2001)

Applications A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Huang, S. et al.: Nature, 461, 614 (2009); Wang, H. et al.: ACS Chem. Biol., 6, 192 (2011); Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009);

Applications ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.
References Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002), Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2003), Kim, M., et al.: Cell, 119, 803 (2004), Tentori, L., et al.: Pharmacol. Res., 52, 25 (2005),

Applications Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.
References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)

Applications MAGNESIUM SULFATE (cas# 7487-88-9) is a useful research chemical.

Applications Copper Dipropanoate is a reagent in the preparation of superconductors and semiconductors.
References PCT Int. Appl. (2015), WO 2015071709 A1 20150521;

Applications (+)-MK 801 Hydrogen Maleate acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.
References Ma, J. et al.: Hippocamp., 22, 2208 (2012); Cao, Z. et al.: Toxicol. Sci., 130, 362 (2012);

Applications Naloxone is a specific opioid antagonist. Narcotic antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993),

Applications Sodium salt of Ethylenediamine-N,N,N’,N’-tetraacetic Acid (EDTA) a powerful chelating agent; EDTA forms stable complexes with most metal ions. EDTA is used in treatment of lead and heavy metal poisoning of farm animals.
References Heindorff, K., et al.: Mutat. Res., 115, 149 (1983); Grier, M.T., et al.: Ann. Pharmacother., 27, 1504 (1993); Krokidis, A.A., et al.: Anal. Chim. Acta, 535, 57 (2005);

Stability Hygroscopic
Applications Synthetic peptide agonist analog of LH-RH. Antineoplastic (hormonal).
References Clayton, R.N., et al.: Clin. Endocrinol., 22, 453 (1985), Gerris, J., et al.: Horm. Res., 45, 279 (1996),

Applications Cilastatin prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. It is an antibacterial adjunct.
References Finlay, K.R., et al.: Invest. Ophthalmol. Visual Sci., 24, 1147 (1983); Norrby, S.R., et al.: Antimicrob. Agents Chemother., 23, 300 (1983); Washburn, D.E., et al.: J. Antimicrob. Chemother., 12, 39 (1983);

Applications Calcium Oxide is an exothermic reagent used in the synthesis of polymers and ceramics.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lee, S. et al.: Mat. Lett., 175, 135 (2016); Dae, J. et al.: J. App. Polym. Sci., 133, (2016);

Applications Sodium Phosphate Dibasic Heptahydrate is used as precursor in the preparation of cobalt-based molecular catalyst for water oxidation.
References Huang, Z., et al.: J. Am. Chem. Soc., 133, 2068 (2011);

Applications Potassium Ferrocyanide Trihydrate functions in the DNA-binding, cytotoxicity, cellular uptake, apoptosis and photocleavage studies of ruthenium(II) complexes.
References Deepika, N., et al.: J. Photochem. Photobiol., B: Biol., 160, 142 (2016)

Applications Anti-inflammatory, analgesic.
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Polascheck, N., et al.: Exper. Neurol., 224, 219 (2010), Gudbjornsson, B., et al.: Eur. J. Clin. Pharmacol., 66, 619 (2010),

Applications (+)-Isomenthol is a reagent that has been used in the preparation of a phosphine activator.
References Rajendran., K.V., et. al.: Tetrahedron Lett., 54, 7009 (2013)

Applications A thiadiazole derivative with fungacidal properties. An antitumor agent.
References Lu, K. et al.: Cancer Chemother. Pharmacol., 4, 275 (1980); Rauckyte, T. et al.: ECOpole’04, Ksiega Konf./Proc., 139 (2004); Nelson, J.A. et al.: Cancer Res., 36, 1375 (1976);

Applications Diclofenac and its combination with Pitofenone and Fenpiverinium shows antispasmodic activity.
References Lundstam, S., et al.: Lancet, 1, 1096 (1982), Thompson, J., et al.: Br. Med. J., 299, 1140 (1989), Marthak, K., et al.: Curr. Med. Res. Opi.,12, 366 (1991),