Réactifs synthétiques

Applications 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.

Applications 4-Fluoro-3-nitrobenzenesulfonyl chloride is a used in the preparation of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.
References Zhou, Haibin., et al.: J. Med. Chem., 55, 6149 (2012);

Applications (R,R)-1,2-Cyclohexanedicarboxylic Acid (cas# 46022-05-3) is a compound useful in organic synthesis.

Applications Fmoc-beta-alaninol

Stability Hygroscopic, Moisture Sensitive
Applications Indium(III) trifluoromethanesulfonate is a catalyst that is used for hetero Diels-Alder reactions including intermolecular Diels-Alder reactions. It is also a catalyst for efficient acylation of alcohols, phenols and amines.
References Kamlesh, K.C., et al.: Synlett, 1999, 1743 (1999), Ali, T., et al.: Tetrahedron Lett., 40, 5621 (1999)

Stability Hygroscopic
Applications A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.
References Lau, O.D. et al.: Mol. Cell, 5, 589 (2000);

Applications GBR 12935 dihydrochloride is a DAT and SLC6A2 inhibitor.

Applications Phenidone is a dual LO (lipoxygenase) and Cox (cyclooxygenase) inhibitor.
References Pilar, G. et al.: J. Phycol., 52, 1085 (2016);

Applications Nickel(II) Bromide, is used as a source of bromide ion. It is also an important raw material used in various chemical synthesis and also as a catalyst in cross-coupling reactions.
References Pramanik, M. et al.: RSC Adv. 2015, 5 (53), 42762-42767.

Stability Air Sensitive (Oxidize)
Applications 3,3-Dimethylbutyraldehyde is an intermediate used to prepare spiro-oxindoles as potent, specific small-molecule Inhibitors of the MDM2-p53 Interaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ding, K., et al.: J. Med. Chem., 49, 3432 (2006); Yu, S., et al.: J. Med. Chem., 52, 7970 (2009)

Applications A useful wittig reagent.