Réactifs synthétiques

Applications 3,4-Dimethoxy-3-cyclobutene-1,2-dione acts as a reagent for the synthesis and mechanism of action of squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27.
References Quintana, M., et al.: MedChemComm, 7, 550 (2016)

Applications 4-(Bromomethyl)benzoic Acid Methyl Ester is an ester derivative of a bromoalkylated benzoic acid. 4-(Bromomethyl)benzoic Acid Methyl Ester is used in the preparation of potential anti-HIV agents. It is also used as a catalyst for rearrangement of benzylthiothiazoline derivatives in the preparation aldose reductase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cushman, M. et al.: Bioorg. Med. Chem. Lett., 8, 833 (1998); Nagao, Y. et al.: Chem. Pharmac. Bull., 36, 509 (1988);

Applications (S,S)-2,3-Butanediol is the (S,S)-isomer of 2,3-Butanediol (B690020), a naturally occurring compound found in cocoa butter.
References Wang, Yu., et al.: J. Biological. Chem., 289, 6080 (2014); Cheng, C., et al.: J. Org. Chem., 78, 8562 (2013);

Applications Ammonium Vanadium Oxide is used in pharmaceutical composition of metformin decavanadate for prevention and treatment of metabolic syndrome, obesity and diabetes. Chimeric design, synthesis, and biological assays of new nonpeptide insulin-mimetic vanadium compounds to inhibit protein tyrosine phosphatase 1B.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Scior, T., et al.: Drug Des. Devel. Ther., 4, 231 (2010); Gonzalez V., et al.: Pat. Appl. (2016), MX 2015003461 A 20160919;

Applications Copper(II) Chloride Dihydrate is a substance used in the release of copper complexes from a nanostructured sol-gel titania for cancer treatment. Also in the solubilization of thymol in Tween 80 micelle to study solubilization mechanism of thymol and effect of solubilization on its antioxidant activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Deng, L., et al.: Scientific Reports, 6, 38160 (2016); Lopez, T., et al.: J. Mater. Sci., 50, 2410 (2015)

Applications GSK 2606414 acts as a potent and selective inhibitor of protein kinase R and similarly endoplasmic reticulum kinase affecting numerous diseases such as cancer.
References Axten, J. et al.: J. Med. Chem., 55, 7193 (2012);

Applications A MEK inhibitor with antitumor activity.
References Lee, W., et al.: Bioorg. Med. Chem. Lett., 15, 3573 (2005), Normanno, N., et al.: J. Cell. Physiology, 207, 420 (2006), Narlawar, R., et al.: J. Med. Chem., 49, 7588 (2006),

Applications α-Acetoxyacetic Acid, is a versatile organic building block, used in the synthesis of pharmaceutical compounds, including inhibitors and therapeutic agents. It can be used for the synthesis of analogs of 5-Aminolevulinic Acid, which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Appleton, D., et al.: J. Chem. Soci., Perkin Transactions , 1, 89 (1998);

Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.

Applications 5-Chloropent-1-yne is an intermediate in the synthesis of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)

Applications Dichlorobis(triphenylphosphine) Palladium (II) is used primarily in organometallic catalytic reactions due to the palladium content of the compound. It is also involved in crystalized structures of metallacyclic complexes which show antiinflammatory and antifungal properties.
References Paul, P. et al.: J. Organometal. Chem., 724, 281 (2013); Pandiarajan, D. et al.: J. Organometal. Chem., 708-709, 18, (2012); Shhaheen, F. et al.: J. Organometal. Chem., 693, 315 (2010);

Applications 1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (cas# 903550-26-5) is a useful research chemical.

Applications 1,2-Diaminopropane-N,N,N',N'-tetraacetic Acid is an aminopolycarboxylic acids found at ultra-trace levels in water; Also, it is used in the construction of Eu3+ ion-selective membrane electrode as suitable ionophore.
References Nette, D., et al.: Anal. Chim. Acta, 884, 124-132 (2015); Abedi, M. R., et al.: E-J. Chem., 8, S467-S473 (2011)

Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).
References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),

Applications 2-(2-Boc-aminoethoxy)ethanol is a reactant that has been used in the synthesis of RGD-conjugated MEK1/2 kinase inhibitors for integrin-targeted cancer therapy.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, X., et. al.: Molecules, 18, 13957 (2013)

Applications Acetylhistamine, is a histamine metabolite, and can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.
References Xu Y, et al. Asian Pac J Allergy Immunol. 2017 Dec;35(4):224-232.;