Composés halogénés

Applications Ethyl 8-chloro-6-hydroxyoctanoate is used in biological study for the enzymic resolution of chiral chlorohydrin precursor for (R)-α-lipoic acid synthesis via lipase catalyzed enantioselective transacylation with vinyl acetate.
References Zhou, W. et al.: Journal of Molecular Catalysis B: Enzymatic (2014), 99, 102-107

Applications tert-Butyl-(3-iodo-1,1-dimethyl-propoxy)-dimethyl-silane (cas# 105262-85-9) is used as a reagent in the preparation of Methyl Acetoacetate.
References Heslin, J. C., et al.: J. Chem. Soc. [Perkin 1]. 6, 1417 (1988)

Applications p-Chloroaniline-d4 Deuterium Chloride is an intermediate in synthesizing N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide-d4 (C377537), an isotope labelled analog of N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide. N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide is an impurity of Chlorhexidine Digluconate (C292770). Chlorhexidine gluconate is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry. It is used in hospitals to prevent infection of patients during surgeries and can also be found in mouth rinses.
References Addy, M. & Wright, R.: J. Clin. Periodont., 5, 198 (1978); Kuruvilla, J. & Kamath, M.: J. Endododont., 24, 472 (1998); Maki, D., et al.: Lancet, 338, 339 (1991); Popovich, K., et al.: Inf. Cont. Hosp. Epidem., 30, 959 (2009); Rosenberg, A., et al.: Surg. Gyn. Obst., 143, 789 (1976)

Applications 1,4-Dichlorocyclohexane is a solvent used in the synthesis of chemical foamed polysulfide sealants for aerospace fuel tank use.
References Stevens, B. E. et al.: U.S. Pat. Appl. Publ. 18 pp. (2017)

Applications 9-Bromononanenitrile is used as a reactant for synthesis and its biological evaluation as potential antitrypanosomal agents.
References Artigas, A., et al.: Lett. Org. Chem. 15, 455 (2018)

Applications 1-Bromo-2-methoxy-d3-ethane is a useful isotopically labeled compound of 2-Bromoethyl Methyl Ether (B685140)

Applications 2-(3,5-Dichloro-2-hydroxyphenyl)-benzo[h]quinoline-4-carboxylic Acid is a useful research chemical.

Applications 16-Bromohexadecanenitrile is a useful research chemical.

Applications N,N-Bis(2-chloroethyl)aniline (cas# 553-27-5) is a useful research chemical.

Stability Hygroscopic
Applications Sodium 2-Iodobenzenesulfonate is useful for the study of IBS-catalyzed oxidative rearrangement of tertiary allylic alcohols.
References Uyanik, M., et al.: Org. Lett., 11, 3470-3473 (2009)

Applications 3-Chloro-N-methylpropan-1-amine Hydrochloride can be used as reactant/reagent in oxidative metabolism of ferrocene analogs of tamoxifen: characterization and antiproliferative activities of metabolites.
References Richard, M. A., et al.: ChemMedChem, 10, 981-990 (2015)

Applications 2-Iodopropane-1,1,1,3,3,3-d6 (CAS# 39091-64-0) is a useful isotopically labeled research compound.

Applications Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylamino)-1,4-dihydropyrimidine-5-carboxylate is a reagent in the synthesis of Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate (M303915) which is an intermediate of Rosuvastatin (R700500).
References Laufer, S., et al.: J. Med. Chem., 45, 2733 (2002), Palani, A., et al.: Bioorg. Med. Chem. Lett., 13, 709 (2003),

Applications Ethyl-6- bromo-4-[(pyrrolyl)-methyl]-5-hydroxy-1-methyl-2-[(phenylthio) methyl]-indole-3-carboxylate is a useful research chemical compound.

Applications Methyl 5-(4-Fluorophenyl)-(5S)-hydroxypentanoate is used in preparation of of Ezetimibe and intermediate thereof.
References Chen, J., et al.: Faming Zhuanli Shenqing, (2020);

Applications 2-[(4-fluorobenzyl)amino]ethanol (cas# 22116-33-2) is a useful research chemical.

Applications 1-Bromopentane-5,5,5-d3 (CAS# 75736-50-4) is a useful isotopically labeled research compound.

Applications α-Chloro-p-methyltoluene-13C is the labeled analogue of α-Chloro-p-methyltoluene(C369770). α-Chloro-p-methyltoluene is a building block that has been used as a reactant for the preparation of 6-aminoquinolone derivatives as submicromolar hepatitis C virus NS5B inhibitors
References Manfroni, G., et. al.: J. Med. Chem., Ahead of Print (2013)

Applications 1-Bromopentadecane-1-13C is a useful isotopically labeled compound of 1-Bromopentadecane (B686155)

Applications 2-(4-Fluorophenyl)-5-[(2-methylphenyl)methyl]thiophene is an intermediate for scalable and cost-effective optimized synthesis of Canagliflozin.
References Metil, D., et al.: Org. Process Res. Dev., 22, 27 (2018)

Applications N-​[4-​Cyano-​3-​(trifluoromethyl)​phenyl]​-​2-​hydroxy-​2-​methylpropanamide is a useful research chemical.

Applications 2-(3-Bromo-4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane is an intermediate in the synthesis of VP 14637 (V785000), an inhibitor used to treat respiratory syncytial virus infections.
References Andries, K., et al.: Antiviral Res., 60, 209 (2003), Douglas, J., et al.: J. Virol., 77, 5054 (2003), Cianci, C., et al.: Antimicrob. Agents Chemother., 48, 413 (2004),