Cétones

<p>Applications 1-(3,4-Dimethoxyphenyl)-2-butanone (cas# 884-06-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Hexachloropropanone is a useful synthetic intermediate. It is a reagent used for the conversion of nucleoside-3′-phosphonates to the corresponding phosphates and for the polymerization of vinyl compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Garegg, P., et al.: J. Chem. Soc. Perkin Trans. I, 6, 1269 (1972); Deming, T., et al.: 26, 7089 (1993)<br></p>

<p>Applications Intermediate in the synthesis of protein kinase inhibitors<br>References Pruehs, C., et al.: Bioorg. Med. Chem. Lett., 17, 1850 (2007), Stukenbrock, H., et al.: J. Med. Chem., 51, 2196 (2008),<br></p>

<p>Applications 1-(4-Benzylphenyl)ethanone is used in the preparation of di- and triarylmethanes through palladium-catalyzed reductive coupling of N-tosylhydrazones and aryl bromides.<br>References Xia, Y., et al.: Synthesis., 49, 1073-1086 (2017)<br></p>

<p>Applications Methyl Pentadecafluoroheptyl Ketone 754-85-8 (cas# 754-85-8) is a useful research chemical.<br></p>

<p>Applications 2-(Dimethylaminomethylene)cyclohexanone is an intermediate in the synthesis of 2-Pentylidenecyclohexanone (P280255), a fragrance chemical. It can also be used in the synthesis of dialkylphenols in the presence of zirconium catalyst.<br>References Tetsuo, B. et al.: Kenkyu Hokoku - Asahi Garasu Zaidan, 58, 201 (1991); Hostynek, J. J., et al.: Toxicology in Vitro, 11, 377 (1997);<br></p>

<p>Applications 1-(4-sec-Butylphenyl)ethanone is a useful synthetic intermediate in the synthesis of 2-(p-sec-Butylphenyl)propionic Acid (B692720); an impurity of Ibuprofen (I140000) which is a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.<br>References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)<br></p>

<p>Applications Reagent used in the preparation of carbazole derivatives<br>References Dong, Y., et al.: J. Med. Chem., 48, 4953 (2005),<br></p>

<p>Applications 8-Didemethyl Baquiloprim-2,4-dione is an intermediate used in the synthesis of Baquiloprim (B118000), which is an amiopyrimidine antibacterial synergist with high activity and slow elimination. Baquiloprim has a better half-life than trimethoprim.<br>References Zhi-hui, H., et al.: Anhui Nongye Kexue, 41, 2503 (2013)<br></p>

<p>Applications 3-(Dimethylphenylsilyl)-cyclobutanone is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.<br>References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);<br></p>

<p>Applications 3,3,5,5-Tetramethylcyclohexanone (cas# 14376-79-5) is a useful research chemical and a pharmaceutical intermediate.<br>References Ebrahimi, H. P., et al.: Spectrochim. Acta A: Mol. Biomol. Spectrosc., 137, 1067 (2015); Bishop, A. C., et al.: Bioorg. Med. Chem. Lett., 16, 4002 (2006)<br></p>

<p>Applications 6-Amino-5-(1,1-dimethylethyl)-3,3-dimethyl-2(3H)-benzofuranone is an intermediate in synthesizing Ivacaftor Carboxylic Acid (I940605). It is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012)<br></p>