Amides

Met-Enkephalin-Arg-Phe amide H-Tyr-Gly-Gly-Phe-Met-Arg-Phe is a subunit of the endogenous opioid peptide Met-enkephalin. It is a proteolytic cleavage product of proenkephalin A and is also known as Tyr2, Phe2, or Arg6. Met-enkephalin has been shown to participate in signal transduction pathways that regulate blood pressure and exocrine secretion. Metenkephalin is an amide containing two cysteine residues with a hydrophobic side chain, which can bind metal ions such as calcium ions. Metenkephalin binds to the membrane of cells, altering membrane potential and naloxone binding sites.
Met enkephalin has been shown to be involved in serotonin release from platelets and inhibition of serotonin uptake by platelets.

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N,N-Dimethylformamide dineopentyl acetal (DMFD) is a synthetic drug that has been used to treat cancer and infectious diseases. It is synthesized from the reaction of dimethylformamide with diethylacetal. DMFD has shown an anti-inflammatory effect in animals, which may be due to its ability to inhibit the production of prostaglandins. The structural analysis of DMFD reveals the presence of two phenyl groups and a hydroxyl group, which are responsible for its biological activity. Structural analysis also led to the determination of several functional groups, including a chloride ion and a methoxy group.

Dithiooxamide is a chemical compound that contains two sulfur atoms, one oxygen atom, and one nitrogen atom. It has been shown to be an effective treatment for wastewater by removing nitrogen and phosphorus. Dithiooxamide binds to metal ions such as copper and iron in the water, forming a complex. This process prevents the metal ions from being available as catalysts in the oxidation of organic pollutants. The binding of dithiooxamide with these metals also removes them from wastewater, preventing them from being taken up by plants or animals. Dithiooxamide can be used to remove malonic acid (a carcinogen) and p-nitrophenyl phosphate (a liver toxin) from blood samples for analysis using electrochemical impedance spectroscopy, which relies on the ability of dithiooxamide to bind to these chemicals. Dithiooxamide is also used as a surfactant in analytical chemistry methods such as gas chromatography or liquid chromatography because it

Dopamine (D2) receptor antagonist; 5-HT4 serotonin receptor agonist

N-(Phenylsulfonyl)palmitamide is a versatile building block that can be used to create complex compounds for research. CAS No. is 527-87-2 and it is a reagent and speciality chemical with high quality. It is also useful as a reaction component in the synthesis of other compounds, or as a scaffold for the synthesis of new derivatives.

N-Ethyl-N-(2-hydroxyethyl)perfluorooctylsulphonamide is a novel glycol ester with cytotoxic effects. It has been shown to inhibit the growth of cancer cells in rat liver microsomes and in vivo. N-Ethyl-N-(2-hydroxyethyl)perfluorooctylsulphonamide inhibits the synthesis of fatty acids by inhibiting the enzyme lipoxygenase. This drug also has a reactive carbon nanotube that may be used as an anticancer agent, which can bind to cell membranes and disrupt their function.

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Kemptamide is a peptide that has been shown to have cytotoxic and anti-proliferative effects on renal cancer cells. It is a synthetic analogue of an endogenous peptide, Lys-Lys-Arg-Pro-Gln-Arg-Ala-Thr-Ser-Asn-Val-Phe, that is found in porcine kidney. Kemptamide’s cytotoxic activity may be due to its ability to inhibit the activity of phosphatases. Kemptamide also has regulatory properties and can modulate the expression of genes that are involved in cell growth and apoptosis. This peptide has been shown to be reactive with kidney cells, which may lead to its therapeutic effect on renal cancer.

Glucagon-like peptide 1 (7-36) amide is a peptide hormone produced by the ileum and colon of the small intestine in response to food intake. It stimulates insulin release from the pancreas, inhibits glucagon secretion, and slows gastric emptying. GLP-1 is also a potent regulator of glucose homeostasis. The GLP-1 analogues are used for treatment of type 2 diabetes mellitus. These analogues are either injected or taken orally and mimic the effect of natural GLP-1 on blood sugar regulation and appetite control. The long duration of action means that daily injections or multiple oral doses are required to maintain therapeutic levels.

Tenofovir alafenamide (free base) is a prodrug of tenofovir with action on viral reverse transcriptase to block replication and is used for treating HIV/AIDS and chronic hepatitis B with improved safety profile.