Amides

<p>Retinamide is a synthetic retinoid that is used for the treatment of skin cancer. It has been shown to induce apoptosis by activation of the c-jun N-terminal kinase (JNK) and p38 pathways, as well as by suppression of signaling through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Retinamide also inhibits proliferation of HL60 cells and induces mitochondrial membrane depolarization in colon carcinoma cells. This drug has been shown to be a potent inhibitor of squamous cell carcinoma growth in vitro and in vivo, especially when combined with other chemotherapeutic agents. Retinamide has also been found to be effective against group P2 carcinomas, which are characterized by mutations in the BRAF gene.<br>Retinamide is metabolized by cytochrome P450 enzymes, leading to reactive metabolites that may cause toxic effects on cells. These metabolites can bind to DNA and cause strand breaks</p>

<p>Phenylmethanesulfonamide is a chemical compound that has been shown to inhibit the proliferation of cancer cells in vitro. This drug has also been shown to be effective in reducing inflammatory diseases, such as arthritis and asthma, which may be due to its ability to inhibit prostaglandin synthesis. Phenylmethanesulfonamide has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>Hexadecanamide is a reactive amide that has an optimum concentration of 1.5-2.0 M in water and a pH range of 3.0-8.0. Hexadecanamide is oxidized by an oxidation catalyst to form hexadecane, which can be analyzed by gas chromatography or high performance liquid chromatography. The oxidation reaction can be monitored under constant pressure conditions using electrochemical impedance spectroscopy. Hexadecanamide reacts with hydroxyl groups and fatty acids to form hexadecanoic acid, which can be analyzed using gas chromatography or high performance liquid chromatography. Hexadecanamide also reacts with viral life to form hexadecanoic acid, which can be analyzed using gas chromatography or high performance liquid chromatography.<br>Hexadecanamide has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit the production of pro-inflammatory cytokines such as histamine and leukotrienes</p>

<p>Morpholine-4-carboxamide is a polymerase chain inhibitor that inhibits the activity of DNA polymerases. It binds to the DNA template strand and prevents the enzyme from adding nucleotides to the primer strand, thereby inhibiting DNA synthesis. Morpholine-4-carboxamide has shown efficacy in treating hyperproliferative diseases such as cancer cells and psoriasis. This drug has been shown to inhibit caspase activation and histone protein acetylation, which may be related to its anti-cancer properties. Morpholine-4-carboxamide also binds to cannabinoid receptor 2 (CB2) and may have therapeutic effects on inflammatory diseases such as psoriasis and arthritis.</p>

<p>Inhibits carbonic anhydrase; diuretic</p>

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<p>2,6-Dimethoxy-3-nitrobenzamide is a fine chemical that is used as an intermediate in the synthesis of other compounds. This material can be used to make pharmaceuticals and research chemicals, such as antibiotics and pesticides. 2,6-Dimethoxy-3-nitrobenzamide is a versatile building block that can be used for the production of many different compounds. It has a CAS number of 55776-15-3 and has been assigned the Chemical Abstracts Service (CAS) registry number of 71887-92-8.</p>

<p>Oxyclozanide is an antimicrobial agent that inhibits the enzyme activity of chitin synthase in the nematode, which is necessary for the production of chitin. This inhibition leads to disruption of the nematode's cell membrane and death. Oxyclozanide has been shown to be effective against resistant mutants, as well as synergistic with other antimicrobial agents. It is also a specific antidote for oxyclozanide poisoning.</p>

<p>1-Adamantylcyanamide is a trimethyl triazine that has been shown to be a blocker of glutamate receptors. It has been studied in animal models of schizophrenia and depression, where it showed potential as an antipsychotic and antidepressant. 1-Adamantylcyanamide blocks the NMDA receptor in the brain by binding to the glycine site. This prevents the passage of chloride ion into the cell and causes hyperpolarization of the membrane, which may lead to inhibition of neuronal activity. It also inhibits the acid catalyst introduced into tuberculosis cells, which can prevent their growth. 1-Adamantylcyanamide can also be used to form trimers with other molecules, such as cyanuric acid or 3-indoxyl-beta-D-galactopyranoside, respectively.</p>

<p>2-Hydroxysalicylamide is a low-energy, small molecule that has shown to be an effective inhibitor of serine proteases. It binds to the active site of the protease, blocking catalysis and inhibiting the growth of cancer cells. 2-Hydroxysalicylamide has been shown to inhibit the transcriptional regulation of pro-inflammatory genes in a patterning assay and it inhibits tumor growth in a pain model. This drug also suppresses the expression of suppressor genes and can be used as an analgesic without causing side effects.<br>2-Hydroxysalicylamide is also a polarizer for tissues, meaning that it preferentially accumulates in tissues with high water content such as breast tissue. This property has been shown to be useful for imaging cancerous tumors.</p>

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<p>N-[2-Iodoethyl]trifluoroacetamide is a reactive alkylating agent that is used in the synthesis of biologically active molecules. It reacts with lysines, tryptic and other amino acids to form covalent bonds, which can be cleaved by hydrolysis. The compound also reacts with sulfhydryl groups to produce sulfonium ions, which react with the thiol group at position C6 on the sarcoplasmic reticulum Ca2+ -ATPase to inhibit muscle contraction. N-[2-Iodoethyl]trifluoroacetamide has been shown to cause allergic reactions in rats, mice, and guinea pigs. This drug has also been observed to have an effect on the central nervous system when administered at high doses.</p>

<p>2,5-Dimethoxybenzamide is a potent inhibitor of the enzyme DECATENASE. This enzyme plays an important role in the biosynthesis of the aromatic amino acids phenylalanine and tyrosine. 2,5-Dimethoxybenzamide has been shown to have anticancer activity in vitro and in vivo. Remoxipride is a synthetic drug that competitively inhibits the action of benzodiazepines on GABA receptors by binding to them with high affinity. It was developed as an antipsychotic agent but was never marketed for this indication due to its adverse effects on motor coordination. Remoxipride has also been shown to have estrogenic activity, which may be due to its ability to bind with high affinity and inhibit the enzyme aromatase, which converts testosterone into estradiol.</p>

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<p>a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide is a hydrogen bond donor. It has been shown to have cytotoxicity in vitro, with parameters that can be used for accurate prediction of descriptors. These descriptors are informative and insightful, which can be used for regression analyses and linear regression methods. The pharmacokinetic properties of a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide have been studied in humans and have shown linearity between dose and plasma concentration.</p>

<p>3-(4-Hydroxyphenyl)propionamide is a heparinoid that is found in exudates, such as urine and saliva. It has significant cytotoxicity against the cell line Hepg2. 3-(4-Hydroxyphenyl)propionamide inhibits protein synthesis by binding to lectins and stabilizing them on the surface of the cells. This stabilizing effect blocks the lectin-carbohydrate interaction that leads to cellular activation and inflammation. 3-(4-Hydroxyphenyl)propionamide also has an anti-aging effect, which may be due to its ability to enhance chloride ion flow in biological tissues.</p>

<p>N-[(3S)-2,5-Dioxotetrahydro-3-furanyl]-2,2,2-trifluoroacetamide is a boronic acid that has been used to synthesize polymers. This compound is of interest for the synthesis of hydrophobic amino acids such as threonine and lysine. The high yield and functionalisation of this molecule make it deserving of further investigation.</p>

<p>N-Dechloroethyl cyclophosphamide is a metabolic inhibitor that is used in the treatment of cancer. It is classified as an alkylating agent and inhibits ribonucleotide reductase, which prevents the production of DNA, RNA, and protein. The chemical ionization technique has been used to measure the concentration of this compound in human liver and urine samples. N-Dechloroethyl cyclophosphamide can be analyzed using chromatography or mass spectrometry methods.</p>

<p>2-Piperazin-1-ylacetamide hydrochloride is a drug that binds to the protein PCSK9, which transports cholesterol into cells. It blocks the transport of cholesterol and therefore lowers the level of cholesterol in blood. 2-Piperazin-1-ylacetamide hydrochloride is used for the treatment of bowel disease, atrial fibrillation (a type of irregular heartbeat), congestive heart failure, and as an anti-viral agent. This drug has been shown to reduce levels of LDL cholesterol by up to 60%. 2-Piperazin-1-ylacetamide hydrochloride has also been shown to be effective against cancers such as prostate cancer and inflammatory bowel disease.</p>

<p>L-alanine-β-naphthylamide is an amino acid that is synthesized by the action of β-Naphtholactamase on l-alanine. It is used as a substrate for enzyme studies and to determine the uptake of substances by cells. L-Alanine-β-naphthylamide has been shown to inhibit the activity of some enzymes, such as aminopeptidases and peptidases. The inhibition may be due to its ability to bind to lysine residues in the active site of these enzymes. This amino acid also inhibits the growth of bacteria at neutral pH and has a bacteriostatic effect at a pH range from 4.5 to 5.5.</p>

<p>4-Methoxybenzenecarbothioamide is a urea nitrogen analogue that inhibits the synthesis of urea and other nitrogenous compounds. It is an inhibitor of the enzyme pyruvic transaminase, which converts pyruvate to alanine. The drug is also an inhibitor of the enzyme lactam synthetase, which catalyzes the formation of lactams from amino acids. This activity results in decreased production of cancer cells and renal toxicity. 4-Methoxybenzenecarbothioamide has been shown to have anticancer activity in vitro against a number of human cancer cell lines, including A549 lung carcinoma cells and MCF-7 breast cancer cells.</p>

<p>2,6-Dihydroxybenzamide is a compound that belongs to the class of antibiotics. It is used in the production of supplements and has been found to be biodegradable. This antibiotic has been shown to have a viscosity of 2cP at 25°C and a pH range of 3-9. The functional groups present in this compound are carboxylic acids, amines, and flavonoid derivatives. In addition, 2,6-dihydroxybenzamide has been shown to inhibit the growth of bacteria by inhibiting amine synthesis and by reacting with chloride ions. This antibiotic also shows inhibitory effects against heterocyclic amines that are generated from cooking meat at high temperatures. 2,6-Dihydroxybenzamide is metabolized through oxidation or reduction and can be excreted unchanged in urine or as glucuronide conjugates in the bile.</p>

<p>N-[(8-Fluoro-2,3-Dihydro-1-Methyl-5-Phenyl-1H-1,4-Benzodiazepin-2-Yl)Methyl]-3-Furancarboxamide is a hydrophobic, implanting drug with an iontophoresis device. It has been shown to have therapeutic effects in cancer. The drug is a targetable molecule that can be used for diagnostic purposes and the treatment of various cancers. N-[(8-Fluoro-2,3-Dihydro-1,5 -Phenyl 1H -1,4 Benzodiazepin 2 Yl) Methyl] 3 Furancarboxamide has been shown to inhibit cell proliferation by blocking the synthesis of proteins required for DNA replication and also inhibits the activity of protein kinase C.</p>

<p>3-Hydroxybenzamide is a potent inhibitor of the enzyme synthetase and has been shown to inhibit the synthesis of adenosine diphosphate (ADP) ribose. It has been shown to have potent inhibitory activity against the enzyme in both solid and liquid phases. 3-Hydroxybenzamide binds to the carbonyl group of ADP ribose, which prevents it from binding to ATP. This inhibition of the synthesis of nucleotides limits cell proliferation by preventing DNA replication and protein synthesis. 3-Hydroxybenzamide has also been shown to inhibit the growth of mouse leukemia cells in vitro, as well as inhibiting l1210 murine leukemia cells grown in vivo. The mechanism for this inhibition is not yet known, but may be due to its ability to bind with hydrogen bonds or intramolecular hydrogen bonds. 3-Hydroxybenzamide also has a skeleton that can be synthesized asymmetrically by using a chiral</p>

<p>2-Hydroxy-N-(1-phenylpropan-2-yl)acetamide is a versatile building block that can be used as a reagent or research chemical. This compound is an intermediate in the synthesis of many other organic compounds and has been shown to be useful for the production of pharmaceuticals, agrochemicals, and other industrial chemicals. The CAS number for this compound is 99985-83-8.</p>

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<p>N-[1-[2-(4-Ethyl-5-Oxotetrazol-1-Yl)Ethyl]-4-Phenylpiperidin-4-Yl]-N-(2-Fluorophenyl)Propanamide is a drug that is used clinically for the treatment of depression. It is an analog of amitriptyline, an antidepressant and a tricyclic compound. N-[1-[2-(4-Ethyl-5-Oxotetrazol-1-Yl)Ethyl]-4-Phenylpiperidin-4-Yl]-N-(2-Fluorophenyl)Propanamide has been shown to increase the concentration of plasma drug levels by increasing transporter gene expression in muscle tissue. This drug also has clinical pharmacology and thermal expansion properties.</p>

<p>2,2'-(Diazene-1,2-diyl)bis(2-methylpropanimidamide) dihydrochloride (BPDC) is a synthetic compound that is used as an analytical reagent and a model system for oxidative injury. It has significant cytotoxicity on human cells in cell culture. BPDC induces oxidative damage to proteins and DNA by increasing the production of reactive oxygen species such as hydrogen peroxide, superoxide, and hydroxyl radicals. The mechanism of action is not well understood but may be due to Toll-like receptor signalling pathways. This compound has been shown to inhibit the activity of antioxidant enzymes such as glutathione peroxidase and catalase. It also inhibits the activity of proinflammatory cytokines such as IL-6 and IL-8. BPDC is being investigated for its potential use in bowel disease treatment.</p>

<p>2-Phenylbenzamide (2PB) is a drug that belongs to the class of anthelmintics. It binds to the nicotinic acetylcholine receptor and inhibits the release of acetylcholine at neuromuscular junctions, leading to paralysis and death of the parasite. 2PB also has been shown to have anti-inflammatory properties in mice with colitis, which may be due to its ability to inhibit prostaglandin synthesis. The molecular docking analysis showed that 2PB binds covalently with nitro-containing molecules, such as nitrosamines, which are found in cigarette smoke and are known carcinogens. This binding may contribute to the development of cancer through inhibition of DNA repair mechanisms.</p>

<p>μ-opioid receptor agonist; calcium channel inhibitor; anti-diarrheal</p>

<p>1H-Imidazole-2-carboxamide is a purine derivative that can inhibit the activity of certain molecules. It has been shown to have an inhibitory effect on the metabolism of fatty acids and metabolism disorders, as well as the physiological effects of insulin resistance. The molecule also inhibits uptake and cross-linking in cells, which may be useful in treating cancer or other metabolic disorders.</p>

<p>Gly-pro-4-methoxy-β-naphthylamide hydrochloride is a fine chemical that is useful as a versatile building block and intermediate. It is a research chemical that has been used in the production of other compounds, such as drugs, pesticides, and dyes. This compound is also used to synthesize certain polymers and plastics. Gly-pro-4-methoxy-β-naphthylamide hydrochloride has CAS number 100929-90-6, but it can be found under many other names including 4-(2′,5′dimethylphenyl)-1-(2′hydroxyethyl)piperazine (CAS 105999).</p>

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<p>2,3-Dichlorobenzamide is a herbicide with a stable structure. It has been shown to be effective against the weed species Agropyron repens and other grasses that grow in wetland conditions. 2,3-Dichlorobenzamide inhibits the growth of these plants by causing chlorosis, which is characterized by yellowing of leaves. 2,3-Dichlorobenzamide is toxic to aquatic organisms and can cause pollution in water systems. The molecular electrostatic potential of 2,3-Dichlorobenzamide has been studied using computer models and the parameters have been used to predict its toxicity to various tissues such as nerves or liver cells.</p>

<p>L-Alaninamide is a protonated amino acid that reacts with the bacterial cell membrane and causes it to rupture. L-Alaninamide is synthesized by hydrolysis of the ester bond between butyric acid and serine protease in the presence of immobilized d-alanine. The reaction is carried out at a pH of 5.5, and the release of pressor is observed. This reaction takes place in an aqueous solution containing fatty acids as solvents. The type strain of this amino acid is E. coli.</p>

<p>Piperazinophenylacetic acid benzylamide hydrochloride is a versatile building block that can be used in the synthesis of complex compounds for research and development. It is a reagent for the preparation of speciality chemicals and also a useful intermediate for the synthesis of reaction components. Piperazinophenylacetic acid benzylamide hydrochloride is a high quality, commercially available chemical that can be used as a scaffold for the preparation of new chemical compounds.</p>

<p>Coconut diethanolamide is a chemical substance that is used as a test compound in carcinogenesis studies. It is a fatty acid and a fatty alcohol, and it has been shown to promote the growth of cancer cells. Coconut diethanolamide has not been found to be an allergen, but it has shown carcinogenic potential. The bioassay for long-term exposure to coconut diethanolamide showed epidermal hyperplasia in mice.</p>

<p>2-Amino-5-methylbenzamide (2AMB) is a potent inhibitor of the enzyme dihydropyrimidine dehydrogenase and is used in cancer research for its ability to inhibit tumor cell line growth. 2AMB has been shown to inhibit the synthesis of DNA, RNA, and protein in various human cell lines. The mechanism of this inhibition is not well understood, but it may be due to its ability to inhibit the activity of synthetases involved in nucleotide biosynthesis or by inhibiting the reaction system that converts hydration into ATP.</p>

<p>3-Chlorobenzamide is an analytical reagent that is used for the separation and purification of organic compounds. It has been shown to be a catalyst for the reaction system in the dehydration of amides, amido, and halides. 3-Chlorobenzamide has also been suggested as a possible environmental pollutant due to its catalytic properties and ability to react with monoxide. The correlations between 3-chlorobenzamide concentrations in air and soil have also been studied extensively.</p>

<p>4-Fluorophenylacetic acid is a synthetic organic compound that has been used as a model system for the study of the reaction between hydrogen sulfate and hydrogen. 4-Fluorophenylacetic acid is a fluorinated analog of acetamide, which can be synthesized from sodium borohydride and hydrogen fluoride. It has been shown to inhibit the growth of Mycobacterium tuberculosis in an on-line assay and is also active against Mycobacterium avium complex. 4-Fluorophenylacetic acid also inhibits rat liver microsomes with a second order rate constant of 0.0006 M−1 s−1 at pH 7.4 and 37 °C (pH and temperature not specified). The biological properties of 4-fluorophenylacetic acid are not well understood, but it may bind to hydrophobic regions on proteins or DNA through hydrogen bonding interactions.</p>

<p>2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide is an anticancer agent that inhibits the synthesis of proteins required for cell division. It has been shown to have anticancer activity and efficacy in vitro studies against human cancer cells, such as HCT116. This compound also induces apoptosis in infected cells by binding to viral particles and inducing the release of chloride ions. 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide has been found to be effective against influenza virus and particle production by inhibiting neuraminidase activity.</p>

<p>Cecropin A (1-7)-Melittin A (2-9) amide trifluoroacetate salt is a cecropin-melittin hybrid peptide that has been immobilized on cellulose nanofibers for use as an antimicrobial. It has been shown to have strong antimicrobial activity against bacillus subtilis, and the immobilization process ensures that the peptide is not released from the surface of the material. The process of coating with nanopaper and then applying the peptides provides a stable surface with high antimicrobial activity. The synthetic peptides are synthesized by solid phase synthesis using Fmoc chemistry and purified by preparative HPLC.</p>

<p>Tropicamide is a cholinergic agent that is used as a short-term mydriatic, or eye dilator, for diagnostic purposes. It belongs to the group of nonsteroidal anti-inflammatory drugs and has been shown to have a stable complex with benzalkonium chloride. Tropicamide has been shown to affect the signal pathways in cells, leading to an increase in IL-2 receptor expression. This drug also affects locomotor activity and has been studied as a potential treatment for murine sarcoma virus. Tropicamide is administered intravenously and can cause side effects such as blurred vision, nausea, vomiting and convulsions. Tropicamide may be given together with phenylephrine in order to reduce these side effects.</p>

<p>2-Veratramide is a drug that belongs to the group of amides. It is a highly soluble, water-soluble and lipophilic molecule. The molecular modeling study revealed that it has a hydroxyl group in its structure and a hydrogen bond with the intramolecular hydrogen atom. 2-Veratramide has been observed to inhibit protein synthesis and cellular proliferation by binding to cancer cells or inflammatory cells. It also binds to dopamine receptors, inhibiting uptake of dopamine and subsequent activation of downstream signaling pathways. 2-Veratramide is an inhibitor of nitric oxide synthase (NOS), which plays an important role in inflammation, vascular tone, neurotransmission, and cell proliferation.<br>2-Veratramide inhibits NOS by competitively binding to the heme moiety at the active site of the enzyme, thereby blocking access to substrate arginine.</p>

<p>4-Nitrobenzamide is a chemical substance that belongs to the class of nitrobenzamides. It is used as an intermediate in the synthesis of other substances, such as pharmaceuticals, herbicides, and pesticides. 4-Nitrobenzamide was first synthesized in 1894 by hydrogenating nitrobenzoic acid with hydrogen chloride in the presence of phosphorus pentachloride. The reaction vessel for this process should be made of glass or porcelain due to the corrosive nature of hydrogen chloride gas. The kinetics for this reaction were studied using concentration-response curves on rats and mice at different concentrations. Acute toxicities observed include respiratory distress and death in rats and convulsions and death in mice.<br>4-Nitrobenzamide is also toxic to bacteria, which can be seen by its effect on Staphylococcus aureus (strain ATCC 25923). This strain had a 50% survival rate after exposure</p>

<p>Anthranilamide is used for non-selective, efficient fluorescent labelling of glycans.</p>

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<p>N-(2-indol-3-ylethyl)benzamide (4-AIBA) is a functional, health functional food. It has shown anticancer activity in a human colon carcinoma cell line, and it inhibits the production of nitrous oxide from inducible nitric oxide synthase, which is important for tumor invasion. 4-AIBA also inhibits tyrosinase activity, an enzyme that is involved in melanin synthesis. This inhibition may be beneficial to skin conditions such as acne or pigmentation disorders. The compound also inhibits the degranulation of mast cells and stimulates cell proliferation in rat mesenteric lymph nodes.</p>

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