Anneaux à 6 chaînons

4-Formyl-N-methylbenzenesulfonamide is a fine chemical that is used as a versatile building block in the synthesis of complex compounds, research chemicals, and reagents. It is highly useful as a reagent or speciality chemical in laboratory experiments involving many different reactions. 4-Formyl-N-methylbenzenesulfonamide has been shown to be an excellent intermediate for the synthesis of high quality products. This product can also be used as a scaffold in complex organic syntheses.

Applications (R)-(-)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate is a chiral building block. It is used to prepare the antifungal agent ketoconazole. It is also used to prepare acyclic Nucleotide Analogs Derived from 8-Azapurines with antiviral activities.
References Rotstein, D., et al.: J. Med. Chem., 35, 2818 (1992); Holy, A., et al.: J. Med. Chem., 39, 4073 (1996)

Applications Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Earl, R., et al.: Org. Synth., 7, 334 (1990); Kluge, A.: Org. Synth., 7, 160 (1990)

Applications N-ethyl-3-phenyl-1-propanamine hydrochloride (cas# 13125-63-8) is a useful research chemical.

Applications 2-(Cyclopropylmethoxy)-acetic Acid 1,1-Dimethyl-2-[4-(methylsulfonyl)phenyl]-2-oxoethyl Ester is a useful research chemical for organic synthesis and other chemical processes.
References Leblanc, Y., et al.: Bioorg. Med. Chem. Lett., 9, 2207 (1999)

Applications 3-(Dimethylphenylsilyl)-cyclobutanone is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.
References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);

Applications p-Toluenesulfonyl Isocyanate has been used to react with a prepolymer with the OH-functionality.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Muenker, A.H., Hudson, B.E.: J. Macromol. Sci. Chem., 3, 1465 (1969)

Applications [3-[(Trimethylsilyl)oxy]-2-cyclohexen-1-yl]-benzene (cas# 108643-81-8) is a compound useful in organic synthesis.

Applications Intermediate in the preparation of Benzoxazines.

Applications 2-(4-Octylphenyl)ethyl Acetate (cas# 162358-04-5) is a compound useful in organic synthesis.

Applications 2-Nitrobenzylcyanide (cas# 610-66-2) is a compound useful in organic synthesis.

Applications α-Chlorophenylacetyl Chloride is a reagent used for dehydrohalogenation of ketones.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Brady, W.T., et al.: J. Org. Chem., 45, 3525 (1980); Brady, W.T., et al.: J. Org. Chem., 45, 2025 (1980);

Applications 3-Benzyloxy-2-(2-hydroxy-2-phenylethyl)-4H-pyran-4-one is an intermediate in the synthesis of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor.

Applications N-(3-Acetylphenyl)-N-ethylacetamide is a reactant used in the preparation of 5-Oxo-Zaleplon (O870470), a metabolite of Zaleplon (Z145000).

Applications 5,6-Dihydro-6-ethenyl-4-hydroxy-2H-pyran-2-one is an intermediate in the synthesis of 4’-Hydroxy rac-Kavain (H944520), which is a metabolite of Kavain (K145490), shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles.
References Gleitz, J., et al: Neuropharmacol., 35, 1743 (1997); Hashimoto, T., et al.: Phytomedicine, 10, 309 (2003); Mulholland, P.J., et al.: Brain. Res., 945, 106 (2002);

Applications 3-BENZYLADENINE (cas# 7280-81-1) is a useful research chemical.

Applications Methyl α-bromophenylacetate is used in synthetic chemistry as an initiator for polymerization reactions (such as the polymerization of methyl methacrylate). Methyl α-bromophenylacetate is also used as a reagent to synthesize compounds that act as selective Serotonin (HCl: S274980) reuptake inhibitors (SSRI). SSRIs are used to modulate symptoms in autistic patients.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fors, B. & Hawker, C.: Angew. Chem. Int. Edit., 51, 8850 (2012); Ghoneim, O., et al.: Bioorgan. Med. Chem. Lett., 21, 6714 (2011); O’Reilly, R., et al.: Macromolecules, 40, 7441 (2007)

Stability Moisture Sensitive
Applications Phenyl Dichlorophosphate is used as a reagent in the synthesis of aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication. Also a reagent in the synthesis of nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as inhibitors of HCV NS5B polymerase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Maiti, M., et al.: Org. Biomol. Chem., 13, 5158 (2015); Jonckers, T.H.M., et al.: J. Med. Chem., 57, 1836 (2014)

Applications (4-(tert-Butyl)-1,2-phenylene)dimethanol is an intermediate in the synthesis of 4-tert-Butyl-1,2-bis(chloromethyl)benzene (B807070). 4-tert-Butyl-1,2-bis(chloromethyl)benzene is used as a reactant in the preparation of dihydronaphthalenes/naphthalenes via cobalt-catalyzed formal [4+2] cycloaddition of α,α'-dichloro-ortho-xylenes with alkynes.
References Komeyama, K., et al.: Angew. Chem. Int. Ed., 53, 11325 (2014)

Applications N,N-Bis(2-hydroxyethyl)benzenesulfonamide is used in the synthesis of N,N-Bis(2-chloroethyl)benzenesulfonamide (B418910), which is a novel intermediate in the synthesis of Cetirizine (C281100).

Applications Methyl 2-benzylhydrazinecarboxylate is an intermediate for the synthesis of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. Inhibits collagen-stimulated platelet aggregation in vitro.
References Kotzki, S. et al.: J. Pharm. Exp. Ther., 346, 424 (2013); Selwood, D> et al.: J. Med. CHem., 44, 78 (2001)

Applications Phosphorylating reagent

Applications Benzyl 4-Fluorophenyl Ketone is used in the preparation and evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.
References Singh, S. et al.: Bioorg. Med. Chem., 12, 1881 (2004);

Applications Methyl 5-(2,2-Dibromoacetyl)-2-hydroxybenzoate is a by-product in the synthesis of Labetalol-1-carboxylic Acid (L096510), an impurity of the α-and β-adrenergic, Labetalol (L096500).

Applications (R)-2-(Benzyloxy)-5-((5-oxotetrahydrofuran-2-yl)methyl)phenyl Neopentyl Sulfate is an intermediate in the synthesis of metabolite of (-)-Epicatechin (E582260).

Applications Dibenzyl azodicarboxylate is a reagent used in the synthesis of Minocycline-d6 (M344797). Minocycline-d6 is a labeled second generation tetracycline antibiotic. Antibacterial.
References Zbinovsky, V., et al.: Anal. Profiles Drug Subs., 6, 323 (1977); Oringer, R.J., et al.: J. Periodontol., 73, 835 (2002)

Applications 4-Benzyloxy-2-(2’-carbomethoxy)thiophenylaniline (cas# 329217-05-2) is a compound useful in organic synthesis.

Applications trans-(1R,2R)-N,N’-Bismethyl-1,2-cyclohexanediamine is a useful research chemical for organic synthesis and other chemical processes.
References Bollenbach, M., et al.: Chem. Eur. J., 23, 13676 (2017); Thaisrivongs, D. A., et al.: Org. Lett., 18, 5780 (2016)

Applications TRIPHENYLSILANE (cas# 789-25-3) is a useful research chemical.

Applications N-Isopropylcyclohexylamine is a reagent that is used in the synthesis of N3-substituted coformycin aglycon analogs that inhibit AMP deaminase or adenosine deaminase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bookser, B.C., et al.: J. Med. Chem., 43, 1495 (2000);

Applications 2-(((10-(Benzyloxy)-10-oxodecan-2-yl)oxy)carbonyl)benzoic Acid is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.

Stability Air and Moisture Sensitive
Applications [Bis(trifluoroacetoxy)iodo]benzene is a reagent that is used in the preparation of XEN907, which is a spiro-oxindole blocker of Nav1.7 for the treatment of pain.
References Chowdhury, S., et al.: Bioorg. Med. Chem. Lett., 12, 3676 (2011);

Applications (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl Dibenzyl Carbamate Phosphate is an intermediate used in the synthesis of Glycerol 3-Phosphoethanolamine (G601595), which is the product of a alcoholysis reaction with phosphatidylcholine and phosphatidylethanolamine.
References Meng, Z., et al.: Zhongguo Youzhi, 38, 32 (2013)

Applications N-(2-Chloroethyl)benzenesulfonamide is an intermediate for the synthesis of Bensulide (B166000), which is an organophosphate acetylcholinesterase inhibitor used as an herbicide (1) in the protection of crops through pesticides (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Applications 2-Phenylpropionitrile (cas# 1823-91-2) is a compound useful in organic synthesis.

Applications 3-(4-Aminophenyl)propionic acid (cas# 2393-17-1) is a useful research chemical.

Applications N-Ethylbenzylamine is a reactant or reagent used in various organic syntheses. It is used in the preparation of CXCR4 injhibitors which are used to treat cancer metastasis and inflammation.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bai, R. et al.: Eur. J. Med. Chem., 118, 340 (2016);

Applications 3-Formyl-4-nitrobenzonitrile is the tri-substitiuted derivative of benzene. 3-Formyl-4-nitrobenzonitrile is an intermediate used in the synthetic preparation of various pharmaceuticals exhibiting large spectrum of activity.
References Kunzer, A.R.. et al. Tetrahedron. Letters., 52, 1815 (2011);

Applications 3,3,5,5-Tetramethylcyclohexanone (cas# 14376-79-5) is a useful research chemical and a pharmaceutical intermediate.
References Ebrahimi, H. P., et al.: Spectrochim. Acta A: Mol. Biomol. Spectrosc., 137, 1067 (2015); Bishop, A. C., et al.: Bioorg. Med. Chem. Lett., 16, 4002 (2006)

Stability Light Sensitive
Applications 4,4'-(1,4-Phenylenebis(ethene-2,1-diyl))dibenzonitrile (cas# 13001-40-6) is a useful research chemical.

Applications 9-(2-Carboxyphenyl)-2,7-dimethyl-3,6-bis(ethylamino)xanthylium is an intermediate in the synthesis of SkQR1 (S555050), a mitochondria-targeted plastoquinone antioxidant that exhibits neuroprotective effect. Potent Mitochondrial Targeted antioxidant protecting against the anti-cancer treatment related to oxidative stress (1). Depicted positive effects on rat memory. (2)SkQRl is the substrate of multidrug resistance pump P-glycoproten (Pgp 170) and selectively protects Pgp 170-negative cells against oxidative stress (3)
References Fetisova EK, et al. 2010. FEBS Lett. Feb 5;584(3):562-6Stelmashook EV, 2015. Biochemistry (Mosc). May;80(5):592-5 Fetisova EK, et al. 2015. Radiat Res. Jan;183(1):64-71

Applications Benzyl 6-Oxohexanoate is an intermediate in the synthesis of N-5-Carboxypentyl-1-deoxynojirimycin (C181200), which is a ligand used for the preparation of an affinity resin highly specific for glucosidase I purification. Glucosidase I is involved in the post-translational processing of N-linked glycoproteins.
References HettKamp, H., et al.: Eur. J. Biochem., 142, 85 (1984); Shailubhai, K., et al.: Biochem. J., 247, 555 (1987); Bause, E., et al.: FEBS, 278, 167 (1991)

Applications Phenyl 2-Chloroethyl Ether (cas# 622-86-6) is a compound useful in organic synthesis.

Applications 5-Bromo-1-(2-fluorophenyl)-2-pentanone is an intermediate in the synthesis of Prasugrel (P701150). Prasugrel is a novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome.
References Von Beckerath, N., et al.: Circulation, 112, 2946 (2005), Jernberg, T., et al.: Eur. Heart J., 27, 1166 (2006), Farid, N., et al.: Drug Metab. Dispos., 35, 1096 (2007), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007), Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 49, 167 (2007), Wiviott, S., et al.: N. Engl. J. Med., 357, 2001 (2007),

Applications (3-(((2-Hydroxyethyl)(methyl)amino)methyl)phenyl)(phenyl)methanone-d3 is an intermediate in the synthesis of Nefopam-d3 (N389402), a cyclized labelled analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants.
References Bassett, et al.: Br. J. Pharmacol., 37, 69 (1969), Klohs, et al.: Arzneim.-Forsch., 22, 132 (1972), Hell, et al.: Drugs, 19, 249 (1980),

Applications 1,5-Dibenzyl Glutarate (cas# 56977-08-3) is a compound useful in organic synthesis.

Applications 2-Hydroxy-4,6-dimethoxybenzoic acid is a reagent used in the synthesis of rac Zearalenone-d6 (Z270502). rac Zearalenone-d6 s an estrogenic mycotoxin produced by Fusarium fungi commonly found in grains. One of a group of compounds known as resorcylic acid lactones.
References Tanaka, T., et al.: J. Agric. Food Chem., 36, 979 (1988), Hamilton, S., et al.: Anticancer Res., 16, 3597 (1996), Hecht, S., et al.: Cancer Lett., 150, 49 (2000), Hussein, H., et al.: Toxicology, 167, 101 (2001), Lim, H., et al.: J. Immunol., 175, 4180 (2005),

Applications 5-Amino-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.
References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)

Applications Diphenyliodonium chloride >=98.0% (AT) (cas# 1483-72-3) is a useful research chemical.

Applications 2-(2,6-Dimethyl-3-hydroxyphenyl)-3-oxo-2-azaindolizidine (cas# 1796881-08-7) is a compound useful in organic synthesis.

Applications 4-Oxocyclohexanecarboxylic Acid is used in the preparation of Indomethacin (I641000) analogues used in the treatment of prostate cancer. In addition it is used in the synthesis of β-alanine derivatives as glucagon receptor antagonists.
References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Lau, J. et al.: J. Med. Chem., 50, 113 (2007);

Stability Store in Freezer
Applications 3-Hydroxyphenylthioacetmorpholide (cas# 500284-27-5) is a compound useful in organic synthesis.

Applications 3-(3,4-Dimethoxyphenyl)-1-(2-hydroxyphenyl)propan-1-one is an intermediate for the synthesis of dTAG-7 (D710015), which is a degradation tag, was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.
References Hai-Tsang Huang., eLife, 1-29, (2017)

Applications 5-(4-Hydroxypentyl)-1,3-benzenediol is an intermediate used in the synthesis of 4''-Hydroxycannabidiol (H824830), which is a metabolite of Canabidiol (C175300), a major constituents in marijuana. 4''-Hydroxycannabidiol be used to investigate canabidiol metabolism and human liver microsomes that metabolize Canabidiol into 6α-Hydroxycannabidiol.
References Jiang, R., et al.: Life Sci. 89, 165 (2011); Lander, N., et al.: Science 169, 611 (1970)

Applications 1,2-Dimethoxy-4,5-dinitrobenzene (cas# 3395-03-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Methyl 2-[2-[(2,5-Dimethylphenoxy)methyl]phenyl]-2-(hydroxy)acetic Acid Ester is an intermediate used in the synthesis of Mandestrobin (M162555), which is a novel fungicide having a methoxyacetamid structure. Mandestrobin also shows safer profiles for human health and the environment.
References Hirotomi, D., & Kiguchi, S.: PCT Int. Appl., WO 2017026526 A1 20170216 (2017)

Applications Used in the preparation of D-xylofuranose derivatives.

Applications Ethyl 4-Iodobenzoate (cas# 51934-41-9) is a compound useful in organic synthesis.

Applications N-(Methoxymethyl)-N-[(trimethylsilyl)methyl]benzenemethanamine is used in the synthesis of pyrrolidine derivatives as novel sodium channel blockers used to treat ischemic related ailments.
References Seki, M. et al.: Bioorg. Med. Chem. Lett., 23, 4230 (2013);

Applications Ethyl (2’-Hydroxy-3’-benzyloxybenzoyl)acetate is an intermediate used in the preparation of 8-Hydroxy Warfarin (H996140).

Applications An intermediate in the preparation of Digallic Acid

Applications n-Butyltriphenylphosphonium Bromide is used in the synthesis of inhibitors of tubulin polymerization thus expressing antimitotic and antitubulin properties. Also used in the synthesis of 3-phenylpropanoic acids as peroxisome proliferator-activated receptor dual agonists affecting the mitochondrial carnitine system.
References Cushman, M. et al.: J. Med. Chem., 38, 2041 (1995); Laghezza, A. et al.: J. Med. Chem., 56, 60 (2013);

Applications 9-[2-[[[10-(4,5-Dimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]oxy]carbonyl]phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-Xanthylium is an intermediate in the synthesis of SkQR1 (S555050), a mitochondria-targeted plastoquinone antioxidant that exhibits neuroprotective effect.
References Isaev, N.K.: Biochem. 77, 996 (2012)

Applications 2-(4-Acetoxyphenyl)ethanol is an intermediate in synthesizing Oleocanthal (O524540). It is a compound of olive oil with potential use as anti-inflammatory and chemotherapeutic agents.
References Scotece, M., et. al.: Drug Discovery Today, 20, 406 (2015)

Applications 2-Phenyl-4-nitrosophenol is an intermediate in the synthesis of (E)-2-((6-Hydroxy-[1,1'-biphenyl]-3-yl)((6-hydroxy-[1,1'-biphenyl]-3-yl)imino)methyl)benzoic Acid which is an impurity of (S)-Cloperastine (C587195); a drug used in the treatment of chronic non-productive cough. Also antitussive.
References Aliprandi, P. et al.: Drugs Exp. Clin. Res., 30, 133 (2004); Aliprandi, P. et al.: Clin. Drug Invest. 22, 209 (2002)

Applications Methyl 4-nitrobenzoate (cas# 619-50-1) is a useful research chemical.

Applications 9-(Benzyloxy)-3,7-dimethylnona-1,7-dien-4-ol is an intermediate in the synthesis of Menaquinone 6 (M218590). Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone-6 were the major isoprenoid quinones found in membrane preparations of Campylobacter jejuni and Campylobacter fetus.
References Kiesel, B., et al.: Biodegradation, 19, 435 (2008), Suhara, Y., et al.: Bioorg. Med. Chem., 16, 3108 (2008), Gast, G., et al.: Nut., Metab., Cardiovas., Diseases, 19, 504 (2009); Carlone G.M., et al.: J. Gen. Microbiol., 129, 3385 (1983);

Applications 1-(4-Benzylphenyl)ethanone is used in the preparation of di- and triarylmethanes through palladium-catalyzed reductive coupling of N-tosylhydrazones and aryl bromides.
References Xia, Y., et al.: Synthesis., 49, 1073-1086 (2017)

Applications tert-Butyl (Triphenylphosphoranylidene)carbamate is used in the preparation of ketimines.
References Yan, W., et. al.: Organic Lett., 14, 2512 (2012)

Applications 2-Benzylaniline was used to study efficient and convenient heterogeneous palladium-catalyzed regioselective deuteration at the benzylic position.
References Kurita, T., et al.: Chem. Eur. J., 14, 664 (2008);

Applications METHYL 2-(4-OXOCYCLOHEXYL)ACETATE (cas# 66405-41-2) is a useful research chemical.

Applications Perfume and flavoring material.

Applications Benzyl 3-Oxo-3-ureidopropanoate is an intermediate in the synthesis of Malonuric Acid (M158100), which is produced during degradation of sodium barbiturates.
References Fretwurst, F., et al.: Arzneimittel-Forschung, 8, 44-50 (1958)

Applications 4,5-Dimethyl-o-phenylenediamine is used in biological processes as a substrate for CobT nicotinate-mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella typhimurium LT2.
References Trzebiatowski, J.R., et al.: J. Biol. Chem., 272, 17662 (1997); Johnson, M.G., et al., J. Biol. Chem., 267, 13302 (1992); Cheong, C., et al.: J. Biol. Chem., 277, 41120 (2002)

Applications 1-(Benzyloxy)-3-[[bis(benzyloxy)phosphoryl]oxy]propan-2-ol is an intermediate in the synthesis of Dihydroxyacetone Phosphate Lithium Salt (D450538), which is a metabolic intermediate involved in involved in a wide variety of metabolic pathways including glycolysis and lipid biosynthesis. In plants, Dihydroxyacetone phosphate is involved with the synthesis of vitamin B6.
References Jun Ogawa et. al.: et al.: Bioscience, biotechnology, and biochemistry, 67(4), undefined (2003-6-6); John P Richard, Biochemistry, 51(13), undefined (2012-3-14);

Applications Diphenyl-methanone Hydrazone is an intermediate used to synthesize Pseudobenztropine (P840155), an analog of Benzotropine (B207575, Mesylate salt) which is used as an antiparkinsonian.. It can also be used to prepare chiral [2.2]paracyclophane-substituted triazolium salts as precursors for copper-triazolylidene-catalyzed asymmetrical boration of unsaturated N-acyloxazolidinones.
References Hai, N., et al.: Int. J. Pharm., 357, 55 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009); Zhan, M., et al.: Org. Lett., 15, 4182 (2013)

Applications Pentadecyltriphenylphosphonium Bromide is an intermediate used in the synthesis of (Z)-12-Heptacosene (H635230), which is an unsaturated lipid and a component of sex pheromones of queen bees (Bobus terrestris) and species of orchids.
References Xu, S.; et al.: Evolution, 65, 2606 (2011); Krieger, G. M.; et al.: L J. Chem. Ecol., 32, 453 (2006).

Applications 2,2-Dimethylpropanoic Acid 1,1'-[[1-Ethyl-2-(4-hydroxyphenyl)-1,2-ethenediyl]di-4,1-phenylene] Ester is an intermediate in the synthesis of ferrocenyl tamoxifen derivatives with modified side chains.
References Nguyen, A., et al.: Chem. Eur. J., 15, 684 (2009);

Applications N-Benzylethanolamine is used in the synthesis of imidazoles as potent calcitonin (CGRP) antagonists. Also it aids in the preparation of benzofused hydroxamix acids, as useful fragments for the synthesis of histone deacetylase inhibitors.
References Tora, G. et al.: Bioorg. Med. Chem. Lett., 23, 5684 (2013); Marastoni, E. et al.: Bioorg. Med. Chem. Lett., 23, 4091 (2013);

Applications 3-(3-(3-(Benzyloxy)propoxy)propoxy)propan-1-ol is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.
References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)

Applications benzyl (2s)-4-oxoazetidine-2-carboxylate, is a building block used for various chemical synthesis such as for the synthesis of NMDA receptor antagonists, 3-alkyl-L-aspartic acids, and orally active β-lactam inhibitors.
References Baldwin, J.E. et al. Tetrahedron 51, 11581-11581, (1995); Hanessian, S. et al. Synlett , 33-33, (1992)

Applications N-[2-[3,4-Bis(phenylmethoxy)phenyl]ethyl]-3,4,5-trimethoxybenzeneacetamide is an intermediate used in the synthesis of S-(-)-Tretoquinol Hydrochloride (T798100), which belongs to the class of adrenergic inhalants, selective β-2-adrenoreceptor agonists. S-(-)-Tretoquinol is used in the treatment of obstructive airway diseases. S-(-)-Tretoquinol is a bronchodilator.
References Meshi, et al.: Biochem. Pharmacol., 19, 2937 (1970), Satoh, et al.: Chem. Pharm. Bull., 19, 667 (1971),

Applications 1-(4-sec-Butylphenyl)ethanone is a useful synthetic intermediate in the synthesis of 2-(p-sec-Butylphenyl)propionic Acid (B692720); an impurity of Ibuprofen (I140000) which is a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.
References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)