Anneaux à 6 chaînons

Applications 1-(Benzyloxy)-3-[[bis(benzyloxy)phosphoryl]oxy]propan-2-ol is an intermediate in the synthesis of Dihydroxyacetone Phosphate Lithium Salt (D450538), which is a metabolic intermediate involved in involved in a wide variety of metabolic pathways including glycolysis and lipid biosynthesis. In plants, Dihydroxyacetone phosphate is involved with the synthesis of vitamin B6.
References Jun Ogawa et. al.: et al.: Bioscience, biotechnology, and biochemistry, 67(4), undefined (2003-6-6); John P Richard, Biochemistry, 51(13), undefined (2012-3-14);

Applications (R)-2-(Benzyloxy)-5-((5-oxotetrahydrofuran-2-yl)methyl)phenyl Neopentyl Sulfate is an intermediate in the synthesis of metabolite of (-)-Epicatechin (E582260).

Applications 5-Bromo-1-(2-fluorophenyl)-2-pentanone is an intermediate in the synthesis of Prasugrel (P701150). Prasugrel is a novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome.
References Von Beckerath, N., et al.: Circulation, 112, 2946 (2005), Jernberg, T., et al.: Eur. Heart J., 27, 1166 (2006), Farid, N., et al.: Drug Metab. Dispos., 35, 1096 (2007), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007), Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 49, 167 (2007), Wiviott, S., et al.: N. Engl. J. Med., 357, 2001 (2007),

Applications 2-Hydroxy-4,6-dimethoxybenzoic acid is a reagent used in the synthesis of rac Zearalenone-d6 (Z270502). rac Zearalenone-d6 s an estrogenic mycotoxin produced by Fusarium fungi commonly found in grains. One of a group of compounds known as resorcylic acid lactones.
References Tanaka, T., et al.: J. Agric. Food Chem., 36, 979 (1988), Hamilton, S., et al.: Anticancer Res., 16, 3597 (1996), Hecht, S., et al.: Cancer Lett., 150, 49 (2000), Hussein, H., et al.: Toxicology, 167, 101 (2001), Lim, H., et al.: J. Immunol., 175, 4180 (2005),

Applications An intermediate used in the production of various ectoparasiticides, drug metabolites and analgesic agents.
References Rastogi, S., et al.: J. Med. Chem., 16, 797 (1973), Maguire, J., et al.: Drug Metab. Disposition, 9, 393 (1981),

Applications 1-Methyl-2-nitrobenzene is a toxic pollutant of the environment because of its large scale use in the production of explosives. It is a useful synthetic intermediate. It shows carcinogenic activity in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sikandar, M., et al.: Chemosphere, 90, 1920 (2013); Jones, C., et al.: Carcinogen., 24, 779 (2003)

Applications 5-Amino-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.
References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)

Applications Wittig reagent.

Applications Methyl 3-(4-chlorophenyl)-3-oxopropanoate (cas# 22027-53-8) is a useful research chemical.

Applications 4-Oxocyclohexanecarboxylic Acid is used in the preparation of Indomethacin (I641000) analogues used in the treatment of prostate cancer. In addition it is used in the synthesis of β-alanine derivatives as glucagon receptor antagonists.
References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Lau, J. et al.: J. Med. Chem., 50, 113 (2007);

Applications 4-Benzyloxybenzoic Acid is a chemical reagent in the preparation of anticancer leads such as quinolin-4-one derivatives.
References Cheng, Y. et al.: Bioorg. Med. Chem. Lett., 23, 5223 (2013);

Applications n-Butyltriphenylphosphonium Bromide is used in the synthesis of inhibitors of tubulin polymerization thus expressing antimitotic and antitubulin properties. Also used in the synthesis of 3-phenylpropanoic acids as peroxisome proliferator-activated receptor dual agonists affecting the mitochondrial carnitine system.
References Cushman, M. et al.: J. Med. Chem., 38, 2041 (1995); Laghezza, A. et al.: J. Med. Chem., 56, 60 (2013);

Applications benzyl (2s)-4-oxoazetidine-2-carboxylate, is a building block used for various chemical synthesis such as for the synthesis of NMDA receptor antagonists, 3-alkyl-L-aspartic acids, and orally active β-lactam inhibitors.
References Baldwin, J.E. et al. Tetrahedron 51, 11581-11581, (1995); Hanessian, S. et al. Synlett , 33-33, (1992)

Applications (αS)-α-Amino-4-nitrobenzenepropanamide (cas# 81677-61-4) is a compound useful in organic synthesis.

Applications Benzyl 3-Oxo-3-ureidopropanoate is an intermediate in the synthesis of Malonuric Acid (M158100), which is produced during degradation of sodium barbiturates.
References Fretwurst, F., et al.: Arzneimittel-Forschung, 8, 44-50 (1958)

Stability Hygroscopic, Light-sensitive
Applications Triphenylmethylium Tetrafluoroborate is reagent used in organic synthesis such as the direct synthesis of 1,1-diphenyl-3-arylindanes.
References Surapanich, N. et al.: Synlett., 27, 2689 (2016);

Applications 1-(3,4-Dimethoxyphenyl)-2-butanone (cas# 884-06-0) is a compound useful in organic synthesis.

Applications (2-Cyclobuten-1-ylseleno)-benzene is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.
References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);

Applications 3,3-Diphenylpropionic Acid is used in the preparation of steroid 5α-reductase inhibiting acylpiperidines. It can also be used in the preparation of calpain-inhibitory piptidyl α-ketoacids and esters.
References Picard, F. et al.: J. Med. Chem., 45, 3406 (2002); Donkor, I. et al.: J. Med. Chem., 51, 4346 (2008);

Applications An intermediate in the preparation of Digallic Acid

Applications 5-(1,1-Dimethylethyl)-3,3-dimethyl-6-nitro-2(3H)-benzofuranone is an intermediate in synthesizing Ivacaftor Carboxylic Acid (I940605). It is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.
References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012)

Applications Benzyl 6-Oxohexanoate is an intermediate in the synthesis of N-5-Carboxypentyl-1-deoxynojirimycin (C181200), which is a ligand used for the preparation of an affinity resin highly specific for glucosidase I purification. Glucosidase I is involved in the post-translational processing of N-linked glycoproteins.
References HettKamp, H., et al.: Eur. J. Biochem., 142, 85 (1984); Shailubhai, K., et al.: Biochem. J., 247, 555 (1987); Bause, E., et al.: FEBS, 278, 167 (1991)

Applications [3-[(Trimethylsilyl)oxy]-2-cyclohexen-1-yl]-benzene (cas# 108643-81-8) is a compound useful in organic synthesis.

Applications N-(β-Cyanoethyl)-N-(ethoxycarbonylethyl)benzylamine is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications (S)-2-(Benzylamino)propan-1-ol is a useful research chemical for the preparation of cross-benzoin products of heteroaromatic aldehydes and amino aldehydes.
References Haghshenas, P., et al.: J. Org. Chem., 81, 12075-83 (2016);

Applications 2-(4-Nitro-2-ethoxyphenyl)pthalimide (cas# 106981-60-6) is a compound useful in organic synthesis.

Applications Methyl 2-[2-[(2,5-Dimethylphenoxy)methyl]phenyl]-2-(hydroxy)acetic Acid Ester is an intermediate used in the synthesis of Mandestrobin (M162555), which is a novel fungicide having a methoxyacetamid structure. Mandestrobin also shows safer profiles for human health and the environment.
References Hirotomi, D., & Kiguchi, S.: PCT Int. Appl., WO 2017026526 A1 20170216 (2017)

Applications 1,4-Bis(diphenylphosphino)butane is a catalyst precursor used in organic synthesis such as the preparation of phenanthrothiazoles.
References Shi, X. et al.: J. Org. Chem., 82, 3886 (2017);

Applications 1,5-Dibenzyl Glutarate (cas# 56977-08-3) is a compound useful in organic synthesis.

Applications Methyl 2-bromobenzoate

Applications 9-[2-[[[10-(4,5-Dimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]oxy]carbonyl]phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-Xanthylium is an intermediate in the synthesis of SkQR1 (S555050), a mitochondria-targeted plastoquinone antioxidant that exhibits neuroprotective effect.
References Isaev, N.K.: Biochem. 77, 996 (2012)

Applications 3-Formyl-4-nitrobenzonitrile is the tri-substitiuted derivative of benzene. 3-Formyl-4-nitrobenzonitrile is an intermediate used in the synthetic preparation of various pharmaceuticals exhibiting large spectrum of activity.
References Kunzer, A.R.. et al. Tetrahedron. Letters., 52, 1815 (2011);

Applications 1-(4-sec-Butylphenyl)ethanone is a useful synthetic intermediate in the synthesis of 2-(p-sec-Butylphenyl)propionic Acid (B692720); an impurity of Ibuprofen (I140000) which is a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.
References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)

Applications N,N-Bis(2-hydroxyethyl)benzenesulfonamide is used in the synthesis of N,N-Bis(2-chloroethyl)benzenesulfonamide (B418910), which is a novel intermediate in the synthesis of Cetirizine (C281100).

Applications Ethyl (2’-Hydroxy-3’-benzyloxybenzoyl)acetate is an intermediate used in the preparation of 8-Hydroxy Warfarin (H996140).

Applications 4-Benzyloxy-2-(2’-carbomethoxy)thiophenylaniline (cas# 329217-05-2) is a compound useful in organic synthesis.

Applications E-3-(4-Benzyloxy)-1-(2.4-bisbenzyloxy-6-hydroxy)phenyl)propenone (cas# 88607-79-8) is a compound useful in organic synthesis.

Applications Used in the preparation of D-xylofuranose derivatives.

Applications 3-(4-tert-Butylbenzene)propionic Acid (cas# 1208-64-6) is a compound useful in organic synthesis.

Applications Dibenzyl azodicarboxylate is a reagent used in the synthesis of Minocycline-d6 (M344797). Minocycline-d6 is a labeled second generation tetracycline antibiotic. Antibacterial.
References Zbinovsky, V., et al.: Anal. Profiles Drug Subs., 6, 323 (1977); Oringer, R.J., et al.: J. Periodontol., 73, 835 (2002)

Applications p-Toluenesulfonyl Isocyanate has been used to react with a prepolymer with the OH-functionality.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Muenker, A.H., Hudson, B.E.: J. Macromol. Sci. Chem., 3, 1465 (1969)

Applications 3-(Dimethylphenylsilyl)-cyclobutanone is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.
References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);

Applications 4-(Benzyloxy)-2-hydroxy-5-(sulfooxy)benzoic Acid is an intermediate used in the synthesis of 4-Hydroxy Flecainide (H942485), which is an analogue of Flecainide (F390000).
References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),

Applications Methyl 2-(3-Nitrobenzylidene)-3-oxobutanoate is a useful reactant in organic synthesis.
References Miao, Chun-Bao, et al.: Heterocycles, 87(4), 853-859 (2013);Kang, Soosung, et al.: Bioorg. & Med. Chem., 21(14), 4365-4373 (2013);Li, Wan, et al.: Archiv der Pharmazie (Weinheim, Germany), 346(9), 635-644 (2013)

Applications 4-(3-Acetoxypropyl)phenyl Acetate is an intermediate used in biological studies for biodistribution and elimination of xenoestrogen nonylphenol in Wistar rats.
References Oriyama, T., et al.: Synlett., 6, 701 (1997);

Applications 9-Hydroxydecanoic Acid Benzyl Ester is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.
References Weber, A. E., et al.: J. Med. Chem., 35, 3755 (1992);

Applications 9-(2-Carboxyphenyl)-2,7-dimethyl-3,6-bis(ethylamino)xanthylium is an intermediate in the synthesis of SkQR1 (S555050), a mitochondria-targeted plastoquinone antioxidant that exhibits neuroprotective effect. Potent Mitochondrial Targeted antioxidant protecting against the anti-cancer treatment related to oxidative stress (1). Depicted positive effects on rat memory. (2)SkQRl is the substrate of multidrug resistance pump P-glycoproten (Pgp 170) and selectively protects Pgp 170-negative cells against oxidative stress (3)
References Fetisova EK, et al. 2010. FEBS Lett. Feb 5;584(3):562-6Stelmashook EV, 2015. Biochemistry (Mosc). May;80(5):592-5 Fetisova EK, et al. 2015. Radiat Res. Jan;183(1):64-71

Applications (R)-(-)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate is a chiral building block. It is used to prepare the antifungal agent ketoconazole. It is also used to prepare acyclic Nucleotide Analogs Derived from 8-Azapurines with antiviral activities.
References Rotstein, D., et al.: J. Med. Chem., 35, 2818 (1992); Holy, A., et al.: J. Med. Chem., 39, 4073 (1996)

Applications 2-(4-Octylphenyl)ethyl Acetate (cas# 162358-04-5) is a compound useful in organic synthesis.

Applications 2-Phenylpropionitrile (cas# 1823-91-2) is a compound useful in organic synthesis.

Applications Chlorobis(4-fluorophenyl)methane is a compound involved in the synthesis of 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine, a T-type calcium channel blocker and anti-ischemic drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Narsaiah, A.V., et al.: Indian J. Chem., 7, 105-107 (2011)

Applications 1,2-Dimethoxy-4,5-dinitrobenzene (cas# 3395-03-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Phenyl-4-nitrosophenol is an intermediate in the synthesis of (E)-2-((6-Hydroxy-[1,1'-biphenyl]-3-yl)((6-hydroxy-[1,1'-biphenyl]-3-yl)imino)methyl)benzoic Acid which is an impurity of (S)-Cloperastine (C587195); a drug used in the treatment of chronic non-productive cough. Also antitussive.
References Aliprandi, P. et al.: Drugs Exp. Clin. Res., 30, 133 (2004); Aliprandi, P. et al.: Clin. Drug Invest. 22, 209 (2002)

Applications Diphenyl Diselenide is an organoselenium compound with pharmacological properties, including antioxidant, glutathione peroxidase-mimetic, and neuroprotective effects. Studies show that Diphenyl Diselenide has demonstrated anxiolytic effects in rodents and can inhibit biofilm formation by Candida albicans, increasing both ROS production and membrane permeability.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hassan, W., et al.: Eur. J. Pharmacol., 761, 341 (2015); Rosseti, I.B., et al.: J. Trace Elem. Med. Bio., 29, 289 (2015); Ibrahim, M., et al.: Prog. Neuro-Psychoph., 54, 187 (2014)

Applications 3-(3-(3-(Benzyloxy)propoxy)propoxy)propan-1-ol is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.
References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)

Stability Air and Moisture Sensitive
Applications [Bis(trifluoroacetoxy)iodo]benzene is a reagent that is used in the preparation of XEN907, which is a spiro-oxindole blocker of Nav1.7 for the treatment of pain.
References Chowdhury, S., et al.: Bioorg. Med. Chem. Lett., 12, 3676 (2011);

Applications 5,7-Bis-(benzyloxy)-2-(4-(benzyloxy)phenyl)-4H-chromen-4-one (cas# 96333-59-4) is a compound useful in organic synthesis.

Applications Diphenyliodonium chloride >=98.0% (AT) (cas# 1483-72-3) is a useful research chemical.

Applications Intermediate in the preparation of alkoxycarbonylthiazolethione derivatives.

Applications Diphenyl-methanone Hydrazone is an intermediate used to synthesize Pseudobenztropine (P840155), an analog of Benzotropine (B207575, Mesylate salt) which is used as an antiparkinsonian.. It can also be used to prepare chiral [2.2]paracyclophane-substituted triazolium salts as precursors for copper-triazolylidene-catalyzed asymmetrical boration of unsaturated N-acyloxazolidinones.
References Hai, N., et al.: Int. J. Pharm., 357, 55 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009); Zhan, M., et al.: Org. Lett., 15, 4182 (2013)

Stability Store in Freezer
Applications 3-Hydroxyphenylthioacetmorpholide (cas# 500284-27-5) is a compound useful in organic synthesis.

Applications N-Depropyl N-Benzyl Propafenone is used in the preparation of Propafenone analogues as antimalarial agents.
References Lowes, D. et al.: J. Med. Chem., 54, 7477 (2011); Ecker, G. et al.: J. Med. Chem., 39, 4767 (1996)

Trimethyl 1,3,5-benzene tricarboxylate is a chemical compound that belongs to the group of polycarboxylic acids. It is used as a polymerization agent in the manufacture of ionic polymers. The first step in this process is cationic polymerization, which involves the reaction between trimethyl 1,3,5-benzene tricarboxylate and sodium citrate to form an ion pair. This process can be followed by hydrolysis with hydrochloric acid and sodium carbonate to release the carboxylate anion from the polymer chain and regenerate trimethyl 1,3,5-benzene tricarboxylate. Trimethyl 1,3,5-benzene tricarboxylate has been shown to have optical properties that depend on its molecular weight and metal surface interactions. It can also be used as a chelating agent for zinc diethyld

2-Iodobenzenesulfonic acid is a synthetic molecule with a molecular weight of 169.27 g/mol. It is an acidic salt that reacts with nucleophilic substitutions, such as hydroxyl groups and heterocycles. 2-Iodobenzenesulfonic acid has been studied using molecular modeling techniques to identify its pharmacophore and the key features that may be important for binding to the active site of the enzyme. The results of these studies show that the most important features are a sulfonyl group, two hydroxyl groups, and an aromatic ring.

5-Propyl-1,3-benzenediol is a chemical compound that is found in cannabis. It has been shown to have anti-inflammatory and neuroprotective effects in vitro. 5-Propyl-1,3-benzenediol also inhibits the growth of cancer cells in vivo by inducing apoptosis.
5-Propyl-1,3-benzenediol can be synthesized from cannabidiol with high yield and selectivity by a one-pot reaction. This product has not been studied for toxicity or other side effects on humans.