Anneaux à 6 chaînons

Applications Substituted cinnamic and dihydrocinnamic acids show anti-inflammatory and analgesic activity, with cinnamic acids being more biologically active.
References Runwal, L. et al.: Eastern Pharmacist 38, 141 (1995)

Applications Methyl 4-amino-2,3,5,6-tetrafluorobenzoate (cas# 715-37-7) is a useful research chemical.

Applications 9,9-Dimethyl-N-phenyl-9H-fluoren-2-amine is useful for the synthetic preparation of secondary amines.
References Yao, W., et al.: Catal. Sci., 9, 3874 (2019)

Applications 3,5-Dimethoxybenzyl Alcohol is used in the synthesis of Resveratrol (R150000).

Applications Methyl 4-amino-2-fluorobenzoate

Applications N-​(3-​Dibenzofuranyl)-​5-​nitro-2-​furancarboxamide is synthesized from Dibenzo[b,d]furan-3-amine (D418205), which is a building block used as a reactant in the preparation of dibenzofuryl(phosphonomethyl)alanines as endothelin converting enzyme inhibitors.
References De Lombaert, S., et al.: J. Med. Chem., 43, 488 (2000);

Applications 5,6,8,9-Tetrahydro-7H-dibenzo[c,g]carbazole (cas# 117766-87-7) is a compound useful in organic synthesis.

Applications Triethylene Glycol Monobenzyl Ether is used in the preparation of self-assembled monolayers with multiple binding sites and biocompatible imprinted cavities for biosensor application. Also used in the synthesis of novel ethoxylated inositol surfactants.
References Zhang, X. et al.: J. Am. Chem. Soc., 135, 9248 (2013); Catanoiu, G. et al.: J. Colloid. Inter. Sci., 371, 82 (2012);

Applications 4-​Hydrazinobenzoic acid hydrochloride (cas# 24589-77-3) is a useful research chemical.

Applications 4-Ethynyltetrahydro-2H-pyran is useful in the synthesis of preparation of aminopyrazine derivatives useful as PI3k-γ inhibitors.
References Douty, B., et al.: U.S. Pat. Appl. Publ., 132 (2020)

Applications Used in the preparation of homobifunctional rhodamine for labeling proteins.
References Corrie, J. et al.; Bioconjugate Chem. 9, 160 (1998)

Applications 5-(3-Benzyloxyphenyl)nicotinic acid

Applications 4-Hydroxybenzylamine (cas# 696-60-6) is a compound useful in organic synthesis.

Applications N-(Benzyloxycarbonyl)ethylenediamine Hydrochloride is a reagent used to synthesize new opioid ligand as an analgesics with mixed agonist and antagonist properties to induce tolerance and dependence.
References Salvadori, S., et al.: Bioorg. Med. Chem., 15, 6876-6881 (2007);

Applications (2S,2aR,2aS,8aR)-2a-(2-((Cyclopropylmethyl)(methyl)amino)ethyl)-2,4,8a-trihydroxy-2,2a,8a-tetrahydro-1H-indeno[1,7,6-bcd]benzo-2-carboxylic Acid is an intermediate used in the synthesis of (4R,4aS,6S,6aR,11bS)-6-Carboxy-3-(cyclopropylmethyl)-1,2,3,4,4a,5,6,6a-octahydro-4a,6,8-trihydroxy-3-methyl-4,11-methanobenzofuro[3',2':2,3]cyclopenta[1,2-c]pyridinium, Inner Salt (C176953), which is an impurity/degradation of N-methyl Naltrexone (M320350), a metabolite of Naltrexone (N285750).
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)

Applications 2-Hydroxy-5-(phenylethynyl)benzoic Acid has antiinflammatory activity.
References Shen, T.-Y., et al.: U.S. (1972), US 3657430 A

Applications Dibenzo[b,d]furan-2-sulfonic acid (cas# 83863-63-2) is a useful research chemical.

Applications 5-Propylbenzene-1,3-diol is an intermediate used to prepare Cannabigerovarin (C175140) which stimulates thermosensitive transient receptor potential (TRP) channels of vanilloid type-4 (TRPV4)-mediated [Ca2+]i with moderate-high efficacy (30-60% of the effect of ionomycin) and potency (EC50 0.9-6.4 μM),
References De Petrocellis, L., et al.: Acta Physiologica, 204, 255 (2012)

Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.

Applications 2,4-Dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.
References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)

Applications 2,3-Dimethylbenzothiazolium Methyl Sulfate (cas# 2038-15-5) is a compound useful in organic synthesis.

Applications Methyl 2-fluoro-3-nitrobenzoate

Applications 9-(2-(Benzyloxy)ethyl)-2-((2-(benzyloxy)ethyl)amino)-1H-purin-6-(9H)-one is an intermediate used in the synthesis of 9-(2-Hydroxyethyl)guanine (H942035), which is an impurity of the antiviral agent Acyclovir (A192400). 9-(2-Hydroxyethyl)guanine is a nucleoside phosphotransferase acceptor.
References Kamimura, A. et al.: Agric. Biol. Chem., 37, 2037 (1973);

Applications Used in the preparation of pyrimidine derivatives.

Applications (4-((4aR)-7-(Benzyloxy)-3,4,4a,5-tetrahydro-2H-chromen-3-yl)phenoxy)(tert-butyl)dimethylsilane is an protected intermediate in the synthesis of isoflavone Daidzein (D103500) related compounds.

Impurity Lubiprostone Impurity VI
Applications 7-((1R,2R,3R)-3-(cyclohexylmethoxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid is a useful chemical reagent.

Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);

Applications 1-PHENYL-1-BUTYNE (cas# 622-76-4) is a useful research chemical.

Applications Tert-butyl 3-amino-4-cyanobenzoate is a useful compound for organic synthesis.

Applications 7-Acetylbenzothiazole is a research reagent used in green and photochemical preparation of heteroarenes via α-heteroarylation of amides and benzaldehyde-catalyzed photoredox reaction ethers
References Zhang, Y., et al.: Chemical Science, 7, 2111 (2016)

Stability Light Sensitive
Applications (E,E)-5-[4-(Diethylamino)phenyl]penta-2,4-dienal is used in polymerization process.
References Innocenzi, P., et al.: J. Mater Chem., 15, 3821 (2005), Cai, Y., et al.: Polymer, 2006, 47, 6560 (2006),

Applications Alpha-(p-toluenesulfonyl)-4-fluorobenzylisonitrile is a useful reagent for the development of DNA-compatible method for novel functionalized imidazoles.
References Geigle, S. N., et al.: Org. Lett., 21, 9001 (2019)

Applications 5-Fluorobenzofuran-3-one

Applications (Z)-Benzyl (2-Amino-2-(hydroxyimino)ethyl)carbamate is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.
References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)

Applications [1-(3-Fluorophenyl)-1-tosyl]methyl isocyanide (cas# 321345-36-2) is a useful research chemical.

Applications Racecadotril intermediate. A β-thiopropionyl-amino acid derivative used as β-lactamase inhibitor.
References Sanger, F., et al.: Biochem. J., 39, 507 (1945), Dawson, P., et al.: Science, 266, 776 (1994),

Applications 3-Formylphenylboronic Acid is a reactant in the synthesis of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gosmini, R., et. al.: J. Med. Chem., 57, 8111 (2014)

Applications A more base-stable alternative to Ellman’s reagent for the quantification of thiol contents and enzymatic assays under basic pH conditions. . It reacts with free thiols similar to Ellman’s reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman’s reagent.
References Zhang, H., et al.: Bioorg. Chem., 26, 356 (1998), Chen, Y., et al.: Biochem., 43, 11491 (2004),

Applications 2-(Tetrahydro-2H-pyran-3-yl)ethanol (cas# 1050493-77-0) is a useful research chemical.

Applications An intermediate for the preparation of Terbutaline.

Applications 1-Nitro-2-[(1E)-2-nitroethenyl]-4-(phenylmethoxy)-benzene is an intermediate used in the synthesis of 5-Hydroxyindole-3-acetic acid (H953605), which is an impurity of chlorpheniramine (C424300), an antihistaminic agent.
References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);

Applications 5-Bromo-7-ethyl-2-formyl-benzofuran (cas# 137206-73-6) is a compound useful in organic synthesis.

Applications (E)-2-Formamido-N-(4-((4-(4-hydroxybutyl)phenyl)diazenyl)phenyl)acetamide is a compound useful in organic synthesis.

Applications m-Maleimidobenzoyl-L-thyroxine Methyl Ester, can be used in the synthesis of a conjugate containing the residues of vitamin H (biotin) and thyroid hormone thyroxine. Biotinylated thyroxine as a bifunctional ligands can be used in the development of a test system for a lanthanide immunofluorometric assay for free thyroxine in human serum.
References Novakovskii, M. E., et al.: Doklady Natsional'noi Akademii Nauk Belarusi, Vol. 52, Iss. 3, P: 66-71 (2008);

Applications 2-Amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole, is an intermediate in the synthesis of pharmaceutical and biologically active compounds including therapeutic agents. It is an intermediate for the synthesis of Pramipexole (P700755).
References Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992), Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997)

Applications 3-(2-Hydroxypropan-2-yl)phenylboronic acid

Applications 4-phenylcyclohexanamine (cas# 19992-45-1) is a useful research chemical.

Applications 1-Benzyl-5-(dicyclohexylcarbodiimido)glutarate (cas# 887352-83-2) is a compound useful in organic synthesis.

Stability Light Sensitive
Applications 3-(3-Hydroxyphenyl)acrylic acid (cas# 588-30-7) is a useful research chemical.

Applications Resorufin Benzyl Ether is a fluorogenic substrate for CYP (cytochrome P450-linked enzymes), commonly used for monitoring P450 activities in cell extracts and solutions.

Applications 3-Hydroxy-2-nitrobenzoic Acid (cas# 602-00-6) is a compound useful in organic synthesis.

Applications N1,N2-Bis(4-hydroxy-2,6-dimethylphenyl)ethanediamide is an intermediate used in the synthesis of 1-Naphthol-d7 (d6 Major) (N367993), which is the isotope labelled analog of 1-Naphthol (N367990), a compound commonly used in the manufacturing of dyes, intermediates, synthetic perfumes.

Stability Moisture Sensitive
Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.
References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);

Stability Store in Freezer, Sensitive to Oxidation
Applications A useful synthetic intermediate.

Applications N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide (cas# 10558-45-9) is a useful research chemical.

Applications 3-PHENYLPROPIOLAMIDE (cas# 7223-30-5) is a useful research chemical.

Applications 2,5-dimethoxycyclohexa-2,5-diene-1,4-dione (cas# 3117-03-1) is a useful research chemical.

Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.
References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);

Applications Benzyltriphenylphosphonium Chloride was used as a reagent in the organic synthesis of several compounds including that of stabilised phosphonium ylides containing saturated oxygen heterocycles. Also used in the synthesis of novel substituted cis-stilbene derivatives which display antimicrobial activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aitken, R., et al.: Org. Biomol. Chem., 14, 1794 (2016); Jain, D., et al.: World J. Pharm. Sci., 4, 1473 (2015);

Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);

Stability Hygroscopic
Applications 5-(4-aminophenyl)-1,3,4-oxadiazol-2-ol (cas# 113118-47-1) is a useful research chemical.

Applications 3-((E)-(2,4-Dimethylphenyl)diazenyl)-2,4-dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.
References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)

Stability Moisture Sensitive
Applications Methyl 3-Phenyloxirane-2-carboxylate (cas# 37161-74-3) is a useful research chemical.

Applications 2-phenylacetohydrazide (cas# 937-39-3) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package