Anneaux à 6 chaînons

Applications Benzyl 2-Chloroethyl Ether is used in the synthesis of phosphane ligands with novel linker units that are complexed with rhodium to be used as building blocks for dendrimer catalysts. Also used in the formation of 2,6-diphenylpyrazine molecule derivatives which display cytotoxic properties.
References Findeis, R. et al.: Eur. J. Inorg. Chem., 1, 99 (2003); Dias, N. et al.: Eur. J, Med. Chem., 40, 1206 (2005);

Applications 3-Nitrobenzoylacetonitrile (cas# 21667-64-1) is a useful research chemical.

Applications 5-AMINO-2-HYDROXYBENZONITRILE (cas# 87029-84-3) is a useful research chemical.

Stability Volatile
Applications 2,3-Dihydropyran is used in the synthesis of potent and selective myeloperoxidase inhibitors useful as antimicrobial oxidants. Also is used to synthesize novel and selective σ1 receptor ligands.
References Soubhye, J. et al.: J. Med. Chem., 56, 3943 (2013); Diaz, J. et al.: J. Med. Chem., 56, 3656 (2013);

Stability Hygroscopic
Applications TRISPHENYL(3,3,3-TRIFLUOROPROP-1-YL)PHOSPHONIUM IODIDE (cas# 128622-15-1) is a useful research chemical.

Applications Reagent used in the preparation of pharmaceutically active Dibenzocyclohenptenes.

Applications 1,4-Cyclohexanediamine

Applications A useful building block for oligoribonucleotide synthesis.
References Shestopalov, I., et al.: Nat. Chem. Biol., 3, 650 (2007),

Applications 2,6-dimethyl-1,3-benzothiazole (cas# 2941-71-1) is a useful research chemical.

Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9

Stability Hygroscopic
Applications 5-(4-aminophenyl)-1,3,4-oxadiazol-2-ol (cas# 113118-47-1) is a useful research chemical.

Applications It can be used in the preparation of sanitizer for use in factories.
References Yuan, H., et al.: Sanitizer used in factory and preparation method thereof, CN 106038470 (2016)

Stability Light Sensitive
Applications 1-Benzyl-1,4-dihydronicotinamide (cas# 952-92-1) is a compound useful in organic synthesis.
References Mailliet, F., et al.: Biochem. Pharmacol., 71, 74 (2005), Sandanayaka, A., et al.: J. Material. Chemis., 17, 2540 (2007),

Applications [4-(2-hydroxyacetamido)phenyl]arsonic acid (cas# 144-87-6) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Acetylbiphenyl is a biphenyl compound that can be prepared via Suzuki-Miyaura and Buchwald-Hartwig reactions of aryl halides or triflates with arylboronic acid and palladium catalysts.
References Littke, A., et al.: J. Am. Chem. Soc., 122, 4020 (2000); Marion, N., et al.: J. Am. Chem. Soc., 128, 4101 (2006);

Applications Benzyltriphenylphosphonium bromide is a useful reactant and reagent for organic reactions and synthesis.
References Hajra, S., et al.: Chem. Comm., 47, 3981-82 (2011); Smith, M.J., et al.: Org. Lett., 2011, 13, 3396-98;

Applications 4-hydroxy-2-nitrobenzoic acid (cas# 74230-08-3) is a useful research chemical.

Applications 2-Isopropoxy-2-phenylacetic acid

Applications 4-N-OCTYLOXYBENZOIC ACID (cas# 2493-84-7) is a useful research chemical.

Applications Used for the preparation of dihydrouracils as anti-ictogenic or anti-epileptogenic agents.
References Akoulitchev, S., et al.: Nature, 377, 557 (1995), Marshall, N., et al.: J. Biol. Chem., 270, 12335 (1995), Marshall, N., et al.: J. Biol. Chem., 271, 27176 (1996), Shapiro, G., et al.: J. Clin. Oncol., 24, 1770 (2006),

Applications methyl 4-(bromomethyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas# 1626407-50-8) is a useful research chemical.

Applications Bis(2,4,5-tribromophenyl)iodonium Hydrogen Sulfate is an intermediate in the synthesis of 2,2',4,4',5,6'-Hexabromodiphenyl ether (H290745), which is a hepatotoxic polybrominated diphenyl ester (PBDE) that is commonly used as a flame retardant. 2,2',4,4',5,6'-Hexabromodiphenyl ether is also sometimes found in food and meats as well, posing a significant risk to humans (especially during pregnancy) and/or animals that consume it. One of the new POPs under the Stockholm Convention
References Johnson, P., et al.: Sci. Total Environ., No vol. given, 445 (2013); Scott, L., et al.: Organo. Comp., 74, 1109 (2012); Zhao, Y., et al.: Env. Sci. Tech., 47, 5939 (2013)

Applications 3,4-Bis(phenylmethoxy)benzeneethanamine is an intermediate used in the synthesis of S-(-)-Tretoquinol Hydrochloride (T798100), which belongs to the class of adrenergic inhalants, selective β-2-adrenoreceptor agonists. S-(-)-Tretoquinol is used in the treatment of obstructive airway diseases. S-(-)-Tretoquinol is a bronchodilator.
References Meshi, et al.: Biochem. Pharmacol., 19, 2937 (1970), Satoh, et al.: Chem. Pharm. Bull., 19, 667 (1971),

Applications N,N-Dicyclohexylmethylamine is used as a reagent in the base preparation of 13C2- and 2H phenethylamines as internal standards for IDMS by Pd-catalyzed double carbonylation of aryl iodides in the presence of amine nucleophiles followed by deoxygenation.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nielsen, D., J. Org. Chem., 74, 6155 (2012)

Applications 3-(1-(Ethylamino)cyclohexyl)phenol is a useful synthesis intermediate.

Applications Wittig Reagent
References Yang, Z., et al.: Bioorg. Med. Chem., 17, 1071 (2009), Shearman, G., et al.: J. Mat. Chem., 19, 598 (2009),

Applications 2-(diphenylacetyl)-3-hydrazino-1H-Inden-1-one is a useful chemical reagent.

Applications Axitinib Iodo Tetrahydropyran is an analog of Axitinib (A794650). Axitinib (A794650) is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003);Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002); Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003);

Applications BENZYL CYANOMETHYLCARBAMATE (cas# 3589-41-1) is a useful research chemical.

Applications (R)-2-(Tetrahydropyranyloxy)propionic Acid can be employed to synthesize lactic acid oligomers, depsides, and depsipeptides on solid phase.
References Kuisle, O., et al.: Tetrahedron Lett. 40, 1203 (1999); Kim, S. et al. tetrahedron asymmetry 22, 1499 (2011)

Applications [4-[[4-(dimethylamino)phenyl]-(4-dimethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]phenyl]-trimethylazanium;dichloride (cas# 82-94-0) is a useful research chemical.

Stability Moisture Sensitive, Toxic
Applications Benzyl Chloromethyl Ether is a reagent in the preparation of benzoyl-hydroxypyrimidine-diones, which are dual inhibitors of HIV reverse transcriptase and integrase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tang, J., et al.: Bioorg. Med. Chem. Lett., 21, 2400 (2011); Berkley, S., et al.; Nat. Med. 16, 981 (2010)

Applications 4-tert-Butyl-N-phenylaniline may be useful in the synthetic preparation of amines via Buchwald-Hartwig amination reaction of aryl thioethers.
References Bismuto, A., et al.: ACS Catal., 10, 4630 (2020)

Applications 2-Cyclohexylvinylboronic Acid is used in the synthesis of vinylbenziodoxolones, a novel type of hypervalent iodine(III) reagents.
References Stridfeldt, E., et al.: Chem. Eur. J., 22, 16066-16070 (2016)

Applications Can be used in the preparation of pyrrolylphenylsulfonates as dopamine D3 antagonists as well as in the preparation of substituted amidothiophene derivatives for use as 11-β-HSD1 inhibitors.

Applications 2-(5-formylfuran-2-yl)benzoic Acid (cas# 88460-72-4) is a useful research chemical.

Applications (S)​-​(-​)​-​1-​Phenyl-​1-​propanol is a building block used in the synthesis of inhibitors of steroid 11-β hydroxylation in the adrenal cortex related to androgen production in the fetus.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zolle, I. et al.: J. med. Chem., 51, 2244 (2008);

Applications 3-Amino-4-(carboxymethyl)benzoic acid

Applications O-(2-Bromo-6-chlorophenyl) O-Ethyl S-Propyl Phosphorothioate is a useful intermediate.

Applications Used in the preparation of antifungal agents.
References Del Poeta, M. et al.; Antimicrob. Agents Ch., 42, 2495 (1998)

Applications 1,3-Diphenylacetone (cas# 102-04-5) is a useful research chemical.

Applications (4-Ethynylphenyl)trimethylsilane (cas# 16116-92-0) is a useful research chemical.

Applications Methyl 4-amino-2-fluorobenzoate

Applications 4-Hydroxyphenylacetone (cas# 770-39-8) is a useful research chemical.

Applications Dibenzo[b,d]furan-2-sulfonic acid (cas# 83863-63-2) is a useful research chemical.

Applications Ethylbenzene is used in the industrial production of styrene trough various organic processes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Weiss, W. et al.: Prog. Surf. Sci., 70, 1 (2002); Cavani, F. et al.: App. Catal. A., 133, 219 (1995);

Applications 3-Formylphenylboronic Acid is a reactant in the synthesis of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gosmini, R., et. al.: J. Med. Chem., 57, 8111 (2014)

Applications 6-Cyclohexylhexanoic Acid (cas# 4354-56-7) is useful for the preparation of N-​Acylethanolamine Acid Amidase (NAAA) inhibitors, which exhibit anti-inflammatory and analgesic activities.
References Ren, J., et al.: RSC Advances, 7, 12455 (2017)

Applications 2-benzylcyclopropane-1-carboxylic acid (cas# 103986-55-6) is a useful research chemical.

Applications 5-Bromo-2-ethoxy-benzenesulfonyl chloride

Applications 2-Isobutyrylcyclohexanone (cas# 39207-65-3) is a useful research chemical.

Applications (1R)-2-(methylamino)-1-phenylethan-1-ol (cas# 495-42-1) is a useful research chemical.

Applications A useful synthetic intermediate for the preparation of novel antiinflammatory agents.

Applications 4'-Dimethylaminophenyl acetylene

Applications Tetrabenzylpentaerythritol is used as a reagent in the preparation of esters via esterification of carboxylic acids with alcohols using uronium-based coupling agents. It is also an intermediate in B536540.
References Twibaniere, J. K., et al.: Org. Lett., 13, 2988 (2011);

Applications Benzyl 6-hydroxyhexanoate is an intermediate in the synthesis of N-5-Carboxypentyl-1-deoxynojirimycin (C181200), which is a ligand used for the preparation of an affinity resin highly specific for glucosidase I purification. Glucosidase I is involved in the post-translational processing of N-linked glycoproteins.
References HettKamp, H., et al.: Eur. J. Biochem., 142, 85 (1984); Shailubhai, K., et al.: Biochem. J., 247, 555 (1987); Bause, E., et al.: FEBS, 278, 167 (1991)

Applications 4-(ethenesulfonyl)benzonitrile (cas# 1154397-48-4) is a useful research chemical.

Applications N-(furan-3-ylmethyl)cyclohexanamine (cas# 462068-58-2) is a useful research chemical.

Applications 4-Nitrotoluene is an explosive material.
References Wollseifen, Rainer, et al.: Separation, 35(1), 28-30 (2015);Cao, Anping, et al.: Nano Letters, 17(1), 1-7 (2017)

Applications (R)-Benzyl (3-Oxo-1-(phenylthio)heptan-2-yl)carbamate is a derivative of N-Carbobenzyloxy-3-phenylthio-L-alanine (C176530) which is an intermediate in the synthesis of Nelfinavir.
References Kaldor, S., et al.: J. Med. Chem., 40, 3979 (1997),