Anneaux à 6 chaînons

Applications 6-Cyclohexylhexanoic Acid (cas# 4354-56-7) is useful for the preparation of N-​Acylethanolamine Acid Amidase (NAAA) inhibitors, which exhibit anti-inflammatory and analgesic activities.
References Ren, J., et al.: RSC Advances, 7, 12455 (2017)

Applications N-[[4-(Phenylmethoxy)phenyl]methyl]-2-[(3-thienylcarbonyl)amino]-4-thiazoleacetamide is derived from ethyl 2-amino-4-thiaxolacetate (E899330) which is used in the synthesis of various pharmaceutical and biologically active compounds including inhibitors and antibiotics.
References Inamoto, Y., et al.: J. Antibiot., 41, 828 (1988)

Applications Repaglinide intermediate.
References Wolfenbuttel, B., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993), Grell, W., et al.: J. Med. Chem., 41, 5219 (1998), Anon., et al.: Drugs Future, 24, 815 (1999),

Applications 2-(Benzyloxy)phenol is used in the synthesis of 2-(benzyloxy)hydroquinone by cytochrome P 450 BM-3 mutant F87V as the catalyst.
References Sulistyaningdyah, W.T., et. al.: Appl. Microbiol. Biot., 67, 556 (2005)

Applications A more base-stable alternative to Ellman’s reagent for the quantification of thiol contents and enzymatic assays under basic pH conditions. . It reacts with free thiols similar to Ellman’s reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman’s reagent.
References Zhang, H., et al.: Bioorg. Chem., 26, 356 (1998), Chen, Y., et al.: Biochem., 43, 11491 (2004),

Applications 2-Amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole, is an intermediate in the synthesis of pharmaceutical and biologically active compounds including therapeutic agents. It is an intermediate for the synthesis of Pramipexole (P700755).
References Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992), Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997)

Applications 3-(2-Hydroxypropan-2-yl)phenylboronic acid

Applications N1,N2-Bis(4-hydroxy-2,6-dimethylphenyl)ethanediamide is an intermediate used in the synthesis of 1-Naphthol-d7 (d6 Major) (N367993), which is the isotope labelled analog of 1-Naphthol (N367990), a compound commonly used in the manufacturing of dyes, intermediates, synthetic perfumes.

Applications 2-Phenyl-2-ethyl-acetyl-guanidine is a compound useful in organic synthesis.

Applications N-Acetyl-N-(phenylmethyl)-propanamide is an intermediate in the synthesis of N-Ethyl-N-nitroso-1-propanamine-d4 (E817997) and isotope labelled version of N-Ethyl-N-nitroso-1-propanamine. N-Ethyl-N-nitroso-1-propanamine is a derivative of N-Nitrosodiethylamine (N525465),a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.
References Shirakami, Y., et al.: Bitamin, 87, 156 (2013); Fujii, Y., et al.: Toxicol., 305, 30 (2013); Uehara, T., et al.: Toxicol. Sci., 132, 53 (2013);

Applications 4-PROPYLPHENYLACETIC ACID (cas# 26114-12-5) is a useful research chemical.

Applications Used for production of peptide thioester.
References Gaeta, A., et al.: Bioorg. Med. Chem. Lett., 20, 4649 (2010),

Stability Light Sensitive
Applications 5,10,15-triphenylcorrole is a trianionic ligand for transition metals.

Applications 1-Phenyl-1-cyclohexene is metabolite of Phencyclidine (P295500), an anesthetic.
References Wong, L.K., et al.L Biomed. Sci. Spec., 2, 204 (1975); Chen, G., et al.: J. Pharmacol. Exp. Ther., 127, 241 (1959); Bailey, K., et al.: J. Pharm. Pharmacol., 28, 713 (1976); Balster, R.L., J. Psychedelic Drugs., 10115 (1978); Johnson, K.M., et al.: Annu. Rev. Pharmacol. Toxicol., 30, 707 (1990)

Applications 3-Phenylcyclohexanone (cas# 20795-53-3) is a useful research chemical.

Applications 6-(4-Phenylbutoxy)-1-hexanamine is an intermediate in the synthesis of salmeterol (S090100), a structural analog of Albuterol (A514500).
References Goswami, J., et al.: Tetrahedron. Asym., 12, 3343 (2002);

Applications (2-Decyl)benzene is a linear alkylbenzene used to synthesize aryl olefins.
References Faghihian, H., et al.: App. Surface. Sci., 264, 492 (2013);

Applications tert-Butyl 2-(3-Aminophenyl)acetate can be used as anti-heparanase to treat diseases and disorders associated with heparanase activity.
References Giannini, G., et.al.: PCT Int. Appl., 103, (2018);

Applications 5-Bromo-2-fluorobenzonitrile

Applications Methyl 5-cyano-2-fluorobenzoate

Applications Intermediate in the synthesis of angiotensin and fosinopril. Impurity in the preparation of Fosinopril Sodium.
References Anderson, N. et al.; Org. Proc Res. and Develop 1, 315 (1997)

Applications 2,3-Dihydroxy-7-sulphamoyl-benzo[f]quinoxaline (cas# 118876-57-6) is a compound useful in organic synthesis.

Applications BENZOYL CYANIDE (cas# 613-90-1) is a useful research chemical.

Applications 2-Amino-N,N-dimethylbenzenesulfonamide is an intermediate used to prepare LDK378 as potent and selective anaplastic lymphoma kinase inhibitor.
References Marsilje, T., et al.: J. Med. Chem., 56, 5675 (2013)

Applications 3-(2-Oxo-cyclohexyl)-propionic Acid is an intermediate in the synthesis of Hexahydrocoumarin (H293905), a derivative of Coumarin (C755380) that is used as a fragrance ingredient.
References Letizia, C. S., et al.: Food and Chemical Toxicology, 38, S115 (2000);

Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.
References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;

Applications 2,4,6-Trimethyl-1,3-benzenediamine is a compound used in the synthesis of various polymers.
References Fritsch, D., et al.: Macromolec. Chem. Phys., 197, 701 (1996)

Applications 3-Phenylpropyne is a useful synthetic intermediate. It is an intermediate used to synthesize carlina oxide. It can also be used to prepare triazole substituted pyrazolopyrimidinamide derivatives via click chemistry as potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Klein, M., et al.: Org. Biomol. Chem., 7, 3421 (2009)

Applications tert-butyl 2-(4-(bromomethyl)phenyl)acetate (cas# 77292-91-2) is a useful research chemical.

Applications (S)-(+)-Z-4-Amino-2-hydroxybutyric Acid is used in the synthesis of aminoglycoside antibiotics.
References Rai, R. et al.: Org. Lett., 8, 887 (2006); Li, Jie. et al.: J. org. Chem., 72, 4055 (2007);

Applications 3-O-tert-Butyldimethylsilyl-cholest-5-ene-3-ol 24-(2-hydroxyisopropyl) 24-Phenyl Sulfinate is an intermediate in the preparation of Campesterol (C155360).

Applications 5-chloro-2,1,3-benzoxadiazol-4-amine (cas# 80277-04-9) is a useful research chemical.

Applications Used for preparation of Terfenadine (T114500) analogs.
References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),

Applications 2-((tert-bButoxycarbonyl)amino)-2-(hydroxymethyl)-4-(4-octylphenyl)butyl Acetate is the intermediate in the synthesis of Mono-O-acetyl Fingolimod TFA (F524600), which is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.
References Brinkmann, V., et al.: Transplantation, 72, 764 (2001). Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002). Mtaloubian, M., et al.: Nature, 427, 355 (2004)

Applications 4-(Dihydroxyborophenyl)acetylene is a reagent used in organic synthesis . It is used in the preparation of purine analogs as PI4K IIIβ inhibitors used in cancer treatment. As well, used in the preparation of demethylase inhibitors for their potential as anti-tumor drugs.
References Sala, M. et al. Bioorg. Med. Chem. Lett., 26, 2706 (2016); Wu, F. et al.: J. Med. Chem., 59, 253 (2016);

Stability Hygroscopic
Applications 2-(2,5-diaminophenyl)ethanol Sulfate (cas# 93841-25-9) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1,1'-[Oxybis(3,1-propanediyloxymethylene)]bis-benzene is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.
References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)

Applications 1-TERT-BUTYL-3-ETHYLBENZENE (cas# 14411-56-4) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1,4-Cyclohexanedimethanol diglycidyl ether (cas# 14228-73-0) is a useful research chemical.

Applications Methyl 2-(Isocyanatosulfonyl)benzoate is an intermediate in the synthesis of Metsulfuron (M227745), a powerful herbicide used in the control of pests and protection of crops and produce.
References Anderson, J. et al.: J. Agric. Food Chem., 37, 1429 (1989); Ivany, J. et al.: Can. J. Plant Sci., 67, 1083 (1987);

Applications 2-Biphenylmethanol is a useful reactant in organic synthesis.
References Li, Zheng, et al.: Bioorg. & Med. Chem., 25(24), 6647-6652 (2017);Shi, Guangfa, et al.: Org. Let., 18(12), 2958-2961 (2016)

Applications Cyclohexyl Vinyl Ketone is a reagent used in the synthesis of α,β-unsaturated carbonyl compounds which are aminotrifluoromethylathiolated.
References Xiao, Q. et al.: Org. LEtt., 17, 6090 (2015) ;

Applications N-benzyl-2,2-dichloroacetamide (cas# 6063-50-9) is a useful research chemical.

Applications Benzenesulfonyl Chloride is used in the synthesis of cecloprotoberberine derivatives as antitumor agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, Y. et al.: Eur. J. Med. Chem., 68, 463 (2013);

Applications 8-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylic Acid (cas# 66411-24-3) is a useful research chemical.

Applications O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine can be used to treat fibrotic and inflammatory diseases.
References Gomer, R.H., et.al., PCT Int. Appl., 167, (2020);

Applications 1-(2-Phenylethynyl)cyclohexanamine is a reactant that functions as a catalyst in the cyclization of propargylamines.
References Zhao, D. et al.: ChemCatChem., 9, 4598 (2017); Yuan, R. et al.: J. Org. Chem., 82, 3639 (2017);

Applications N-(4-Hydroxymethylbenzyl)trifluoroacetamide (cas# 171723-95-8) is a compound useful in organic synthesis.

Applications 2-((Tetrahydrofuran-2-yl)methoxy)phenoxy)tetrahydro-2H-pyran is an intermediate used in the synthesis of Bufetolol (B689435), a β-adrenergic blocking agent and it inhibits the activation of adenyl cyclase.
References Ikegami, K., and Imamura, H.: Yakugaku Zasshi 96, 614 (1976); Yamaji, A., et al.: Yakugaku Zasshi 105, 1179 (1985)

Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.
References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)

Applications Methyl 3,5-dibromo-4-hydroxybenzoate (cas# 41727-47-3) is a useful research chemical.

Applications 2,2-Dimethyl-3-(4-mercaptophenyl)propionic Acid (cas# 887354-80-5) is a compound useful in organic synthesis.

Applications [(Methoxy)methyl]triphenylphosphonium Chloride is used in the synthesis of Cephalotaxine (C261050), an antiviral and antitumor agent. Also used in the synthesis of Taxol A fragment.
References Sells, M., et al.: J. Virol., 62, 2836 (1988), Kaneko, S., et al.: J. Clin. Microbiol., 27, 1930 (1989), Baba, Y., et al.: Bioorg. Med. Chem., 13, 5164 (2005), Romero, M., et al.: Antiviral Res., 68, 75 (2005); Hirai, S. et al.: Tetrahedron Lett., 54, 1888 (2013); Xing, P. et al.: Synth., 45, 596 (2013);

Applications 2-Isobutyryl-N-phenyl-3-phenylacrylamide is the labeled analogue of 2-Isobutyryl-N-phenyl-3-phenylacrylamide (I781040), an intermediate for the synthesis of Atorvastatin-d5 Sodium Salt (A791753), the labeled analogue of Atorvastatin (A791750) (1,2,3). Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993) (2) Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996) (3) Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Applications 2-Phenylcyclobutan-1-one (cas# 42436-86-2) is a useful research chemical.

Applications 2-Butyl-4,6-dihydroxybenzoic Acid is an intermediate in preparation of compounds for study in primin and miconidin biosynthesis routes in Primula obconica.
References Horper, W., et al.: Phytochem., 41, 451 (1996);

Applications 2-Aminobenzenesulphonic acid (cas# 88-21-1) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-​Morpholinocyclohex-​1-​en-​1-​yl Trifluoromethanesulf​onate is a reagent used in the preparation of inhibitors of c-Jun N-terminal kinase in the treatment of neurodegenerative disorders and autoimmune diseases.
References Graczyk, P. et al.: PCT Int. Appl. (2010), WO 2010015803 A1 20100211.

Applications 4-Acetylphenylboronic acid4-Acetylphenylboronic Acid is used in several metal catalyzed cross-coupling reaction studies.
References Saito, S., et al.: J. Org. Chem., 2, 8024 (1997); Sakai, M., et al.: Organomet., 16, 4229 (1997); Molander, G., et al.: J. Org. Chem., 68, 4302 (2003);

Applications 4-(4-hydroxyphenyl)butanoic acid (cas# 7021-11-6) is a useful research chemical.

Applications 4-(Methylamino)benzoic Acid (cas# 10541-83-0) is a compound useful in organic synthesis.

Applications 3-Phenyl-1-butanol is a reactant with primary alcohol functional group which is oxidized to aldehyde using the nanoparticle-ferrite-palladium catalyst.
References Polshettiwar, V., Varma, R.: Org. Biomol. Chem., 7, 37 (2009);

Applications 2,6-Dimethylphenylboronic acid

Applications 4,4'-Dimethyldiphenylamine is a reagent used in the comparative studies of the analgesic and anti-inflammatory properties of N-phenylanthranilic acids and mefenamic acid, and the anti parasitic activities of some substituted diphenylamines.
References Izard-Verchere, C., et al.: Chimica Therapeutica, 6, 346 (1971)

Applications (2R,​3S,​4S,​5S)-5-Hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone was used in the synthetic preparation of N-substituted valiolamine derivatives.
References Fukase, H., et al.: J. Org. Chem., 57, 3642 (1992);

Applications Benzyl 2,2,2-Trifluoroethyl Sulphide is a useful intermediate for the preparation of trifluoroethanesulfonic acid
References Bunyagidj, C., et al.: J. Org. Chem., 46, 3335 (1981)

Applications N-(4-Bromophenyl)-[1,1-biphenyl]-4-amine is a useful reagent for preparing carbazole and dibenzofuran-linked tertiary arylamine compounds, which may improve electroluminescent properties.
References Ito, H., et al.: Jpn. Kokai Tokkyo Koho (2020), JP 2020093979 A